Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp
Open accessAbstract
Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has several limitations, mainly associated with its toxicity. Although some lipidic and liposomal formulations that present reduced toxicity are available, their price limits their application in developing countries. Flucytosine (5FC) has shown synergistic effect with AmB for treatment of some fungal infections, such as cryptococcosis, but again, its price is a limitation for its use in many regions. In the present work, we aimed to identify new drugs that have a minor effect on Cryptococcus neoformans , reducing its growth in the presence of subinhibitory concentrations of AmB.
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Subsequent studies to identify compounds that augment amphotericin B and fluconazole activity against Cryptococcus spp. identified numerous antipsychotic drugs, including sertraline, trifluoperazine and thioridazine.
“Subsequent studies to identify compounds that augment amphotericin B and fluconazole activity against Cryptococcus spp. also identified numerous antipsychotic drugs, including sertraline, trifluoperazine and thioridazine112,113.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [113]
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References 75 · Cited by 48
- Authors
- Rossi, S. A., de Oliveira, H. C., Agreda-Mellon, D., Lucio, J., Mendes-Giannini, M. J. S., García-Cambero, J. P., & Zaragoza, O.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
- Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Câmpus Araraquara, Departamento de Análises Clínicas, Araraquara, Brazil
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2020-03-24
- Volume
- 64
- Issue
- 4
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC7179310
- OpenAlex
- W3002303138
- Cited by
- 48
- References
- 75
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 6 · 2021: 7 · 2020: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Ministerio de Economía, Industria y Competitividad, Gobierno de España (SAF2014-54336-R, SAF2017-86192-R)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- amphotericin B, drug synergy, off-patent drugs, Cryptococcus neoformans, Candida, antifungal activity, subinhibitory concentrations, 5-fluorocytosine, cryptococcosis, antifungal toxicity, drug repurposing
- MeSH terms
- RAW 264.7 Cells, Ciclopirox, Amphotericin B, Animals, Antifungal Agents, Auranofin, Candida albicans, Candidiasis, Cell Line, Cryptococcosis, Cryptococcus neoformans, Drug Evaluation, Preclinical, Drug Synergism, Erythromycin, Flucytosine, Humans, Microbial Sensitivity Tests, Opportunistic Infections, Zebrafish, Mice, Drug Repositioning
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