Intraocular penetration of intravenous micafungin in inflamed human eyes
Open accessAbstract
Eight eyes of 7 patients with fungal disease received intravenous injections of 150 to 300 mg micafungin, and samples of blood, cornea, retina-choroid, aqueous humor, and vitreous humor were collected. The micafungin levels in all collected samples exceeded the MICs; however, the levels in the vitreous and aqueous humors were lower. Our findings suggest that intravenous micafungin should be given in combination with intravitreal antifungal agents after vitrectomy in severe cases of intraocular fungal diseases.
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For fluconazole-resistant isolates, liposomal amphotericin B is preferred over echinocandins, which achieve suboptimal vitreous concentrations.
“For fluconazole-resistant isolates, liposomal amphotericin B is preferred over echinocandins, which achieve suboptimal vitreous concentrations [109,110].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [109]
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Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
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- Authors
- Mochizuki, K., Sawada, A., Suemori, S., Kawakami, H., Niwa, Y., Kondo, Y., Ohkusu, K., Yamada, N., Ogura, S., Yaguchi, T., Nishimura, K., & Kishino, S.
- Affiliations
- Gifu University (JP)
- Gifu Municipal Hospital (JP)
- Gifu Prefectural General Medical Center (JP)
- Chuno Kosei Hospital (JP)
- Chiba University (JP)
- Dokkyo Medical University (JP)
- Meiji Pharmaceutical University (JP)
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2013-08
- Volume
- 57
- Issue
- 8
- Pages
- 4027-4030
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3719741
- OpenAlex
- W1969014414
- Cited by
- 41
- References
- 17
- Citations by year
- 2026: 4 · 2025: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- micafungin, intraocular penetration, intravenous administration, vitreous humor, aqueous humor, cornea, vitrectomy
- MeSH terms
- Micafungin, Aged, Aged, 80 and over, Antifungal Agents, Aqueous Humor, Aspergillus, Candida, Cornea, Female, Humans, Male, Endophthalmitis, Vitrectomy, Vitreous Body, Echinocandins, Lipopeptides, Injections, Intraocular
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