The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles
Open accessAbstract
Delivery of antituberculosis drugs by nanoparticles offers potential advantages over free drug, including the potential to target specifically the tissues and cells that are infected by Mycobacterium tuberculosis , thereby simultaneously increasing therapeutic efficacy and decreasing systemic toxicity, and the capacity for prolonged release of drug, thereby allowing less-frequent dosing. We have employed mesoporous silica nanoparticle (MSNP) drug delivery systems either equipped with a polyethyleneimine (PEI) coating to release rifampin or equipped with cyclodextrin-based pH-operated valves that open only at acidic pH to release isoniazid (INH) into M. tuberculosis -infected macrophages. The MSNP are internalized efficiently by human macrophages, traffic to acidified endosomes, and release high concentrations of antituberculosis drugs intracellularly. PEI-coated MSNP show much greater loading of rifampin than uncoated MSNP and much greater efficacy against M. tuberculosis- infected macrophages. MSNP were devoid of cytotoxicity at the particle doses employed for drug delivery. Similarly, we have demonstrated that the isoniazid delivered by MSNP equipped with pH-operated nanovalves kill M. tuberculosis within macrophages significantly more effectively than an equivalent amount of free drug. These data demonstrate that MSNP provide a versatile platform that can be functionalized to optimize the loading and intracellular release of specific drugs for the treatment of tuberculosis.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Approximately 90% of MSNP was intracellularly colocalized with CD63 after 3 h of incubation.204”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [204]
In the citing paper
“The majority of the macrophages that were incubated with RITC-labeled NP-RIF internalized the fluorescent nanoparticles and exhibited 10-fold higher fluorescence intensity than the untreated control macrophages.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [204]
In the citing paper
“Drug-specific surface functionalization has been employed for RIF, and further functionalization with poly(ethylene imine) (PEI) yields high loading and controlled drug delivery to MTB-infected macrophages compared to uncoated MSNP.204”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [204]
In the citing paper
“On the other hand, in the case of INH, MSNP decorated with pH-operated nanovalves has been designed to open after endocytosis and endosome acidification to deliver the drug directly to MTB-infected macrophages.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [204]
In the citing paper
“Functionalized MSNP can be internalized efficiently, as confirmed by using human macrophages such as THP-1 cells.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [204]
In the citing paper
“at an acidic pH, the plug is lost, resulting in drug release.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [66]
Citations
Cites
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Liong, M., Lu, J., Kovochich, M., Xia, T., Ruehm, S. G., Nel, A. E., Tamanoi, F., & Zink, J. I. (2008) · ACS Nano · doi:10.1021/nn800072t · Cited by 1,968
Self-citationLu, J., Liong, M., Li, Z., Zink, J. I., & Tamanoi, F. (2010) · Small · doi:10.1002/smll.201000538 · Cited by 1,095
Self-citationMesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery
Vivero-Escoto, J. L., Slowing, I. I., Trewyn, B. G., & Lin, V. S. ‐. (2010) · Small · doi:10.1002/smll.200901789 · Cited by 1,024
Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
Lu, J., Liong, M., Zink, J. I., & Tamanoi, F. (2007) · Small · doi:10.1002/smll.200700005 · Cited by 1,012
Self-citationThe effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
Huang, X., Teng, X., Chen, D., Tang, F., & He, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.060 · Cited by 1,002
Xia, T., Kovochich, M., Liong, M., Meng, H., Kabehie, S., George, S., Zink, J. I., & Nel, A. E. (2009) · ACS Nano · doi:10.1021/nn900918w · Cited by 933
Self-citationMeng, H., Liong, M., Xia, T., Li, Z., Ji, Z., Zink, J. I., & Nel, A. E. (2010) · ACS Nano · doi:10.1021/nn100690m · Cited by 915
Self-citationSilica Particles: A Novel Drug‐Delivery System
Barbe, C., Bartlett, J. R., Kong, L., Finnie, K. S., Lin, H., Larkin, M., Calleja, S., Bush, A. J., & Calleja, G. (2004) · Advanced Materials · doi:10.1002/adma.200400771 · Cited by 858
Flagged first, then by citations
Research works printed but not linked: 1
- MalabarbaA FerrariP DepaoliA GalloGG CavalleriB. 1986. Synthesis and conformation of some acetyl derivatives of rifampicin. Farmaco Sci. 41:131–150.
Cited by
Sorted by citations
Items 101–200 of 262
Liu, Z., Li, X., Xiu, B., Duan, C., Li, J., Zhang, X., Yang, X., Dai, W., Johnson, H., Zhang, H., et al. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.05.085 · Cited by 32
Jafari, A., Mosavari, N., Movahedzadeh, F., Nodooshan, S. J., Safarkar, R., Moro, R., Kamalzadeh, M., Majidpour, A., Boustanshenas, M., & Mosavi, T. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.07.010 · Cited by 32
Mahajan, K. D., & Bhattacharya, S. (2024) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266287101240214071718 · Cited by 31
Swain, S. S., Paidesetty, S. K., Padhy, R. N., & Hussain, T. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13685 · Cited by 30
Bergs, C., Brück, L., Rosencrantz, R. R., Conrads, G., Elling, L., & Pich, A. (2017) · RSC Advances · doi:10.1039/c7ra06332f · Cited by 29
In vitro controlled release of Rifampicin through liquid-crystalline folate nanoparticles
Parmar, R., Misra, R. D., & Mohanty, S. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.03.051 · Cited by 28
State of the art and future directions in nanomedicine for tuberculosis
Dube, A., Lemmer, Y., Hayeshi, R. K., Balogun, M. O., Labuschagne, P. W., Swai, H., & Kalombo, L. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.846905 · Cited by 28
Chawla, R., Jaiswal, S., & Mishra, B. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.807794 · Cited by 28
Alginate Nanoparticles: A Potential Drug Carrier in Tuberculosis Treatment
Patel, R. P., Patel, G. K., Patel, N. A., Singh, S. K., & Chittasupho, C. (2023) · Springer eBooks · doi:10.1007/978-3-031-14100-3_11 · Cited by 27
Antibiotic Drug Delivery Systems for the Intracellular Targeting of Bacterial Pathogens
Chifiriuc, M. C., Holban, A. M., Curuțiu, C., Diţu, L.-M., Mihăescu, G., Oprea, A. E., Grumezescu, A. M., & Lazăr, V. (2016) · InTech eBooks · doi:10.5772/61327 · Cited by 26
A review on recent advances in nanomedicines for the treatment of pulmonary tuberculosis
Chaudhary, K. R., Puri, V., Singh, A., & Singh, C. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.103069 · Cited by 25
Yang, Z., Lou, C., Wang, X., Wang, C., Shi, Z., & Niu, N. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07791-8 · Cited by 25
Xia, X., Pethe, K., Kim, R., Ballell, L., Barros, D., Cechetto, J. D., Jeon, H.-K., Kim, K., & Garcia‐Bennett, A. E. (2014) · Nanomaterials · doi:10.3390/nano4030813 · Cited by 25
Cationic inhalable particles for enhanced drug delivery to M. tuberculosis infected macrophages
Sharma, P. R., Dravid, A. A., Kalapala, Y. C., Gupta, V. K., Jeyasankar, S., Goswami, A., & Agarwal, R. (2021) · Biomaterials Advances · doi:10.1016/j.msec.2021.112612 · Cited by 25
Trousil, J., Dal, N. K., Fenaroli, F., Schlachet, I., Kubíčková, P., Janoušková, O., Pavlová, E., Škorič, M., Trejbalová, K., Pavliš, O., et al. (2022) · Small · doi:10.1002/smll.202201853 · Cited by 24
Bergman, L., Kankaanpää, P., Tiitta, S., Duchanoy, A., Li, L., Heino, J., & Lindén, M. (2013) · Molecular Pharmaceutics · doi:10.1021/mp3005879 · Cited by 24
Afinjuomo, F., Barclay, T. G., Parikh, A. R., Chung, R., Song, Y., Nagalingam, G., Triccas, J. A., Wang, L., Liu, L., Hayball, J. D., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110555 · Cited by 24
Mesoporous Silica Nanoparticles as a Potential Platform for Vaccine Development against Tuberculosis
Montalvo-Quirós, S., Vallet‐Regí, M., Palacios, A., Anguíta, J., Prados‐Rosales, R., González, B., & Luque-Garcia, J. L. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121218 · Cited by 24
Guest-host Relationship of Cyclodextrin and its Pharmacological Benefits
Alshati, F., Alahmed, T. A. A., Sami, F. M., Ali, S., Majeed, S., Murtuja, S., Hasnain, M. S., & Ansari, M. T. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128266398231027100119 · Cited by 23
Macrophages Targeted Drug Delivery as a Key Therapy in Infectious Disease
Cătoi, C. (2014) · Cited by 23
Noschka, R., Gerbl, F., Löffler, F., Kubis, J., Rodríguez, A., Mayer, D., Grieshober, M., Holch, A., Raasholm, M., Forssmann, W., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.618278 · Cited by 23
Zowalaty, M. E. E., Hussein, M. Z., Arulselvan, P., Fakurazi, S., Webster, T. J., Geilich, B., & Bullo, S. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s102406 · Cited by 23
In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis
Acharya, A. P., Sezginel, K. B., Gideon, H. P., Greene, A. C., Lawson, H., Inamdar, S., Tang, Y., Fraser, A. J., Patel, K. V., Liu, C., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.024 · Cited by 22
Bullo, S., Arulselvan, P., Zowalaty, M. E. E., Fakurazi, S., Webster, T. J., Geilich, B., & Hussein, M. Z. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/401460 · Cited by 22
Antibiotic-Loaded Polymersomes for Clearance of Intracellular Burkholderia thailandensis
Porges, E., Jenner, D. C., Taylor, A. W., Harrison, J. S. P., Grazia, A. D., Hailes, A. R., Wright, K. M., Whelan, A. O., Norville, I. H., Prior, J. L., et al. (2021) · ACS Nano · doi:10.1021/acsnano.1c05309 · Cited by 21
Almomen, A. A., & Alhowyan, A. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15030074 · Cited by 21
Breaking barriers: The potential of nanosystems in antituberculosis therapy
Canales, C. S. C., Cazorla, J. I. M., Cazorla, R. M. M., Roque‐Borda, C. A., Polinário, G., Figueroa-Banda, R., Sábio, R. M., Chorilli, M., Santos, H. A., & Pavan, F. R. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.013 · Cited by 21
Cyclodextrin Inclusion Complexes Loaded in Particles as Drug Carrier Systems
Fraceto, L. F., Grillo, R., & Sobarzo‐Sánchez, E. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026613666131219124847 · Cited by 21
Infectious Diseases: Need for Targeted Drug Delivery
Devarajan, P. V., Dawre, S., & Dutta, R. (2014) · Advances in delivery science and technology · doi:10.1007/978-3-319-11355-5_3 · Cited by 21
Nanomedicine: New Frontiers in Fighting Microbial Infections
Mehrabi, M. R., Soltani, M., Chiani, M., Raahemifar, K., & Farhangi, A. A. (2023) · Nanomaterials · doi:10.3390/nano13030483 · Cited by 20
Nanomaterials against intracellular bacterial infection: from drug delivery to intrinsic biofunction
Chen, Y., He, X., Chen, Q., He, Y., Chen, F., Yang, C., & Wang, L. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1197974 · Cited by 22
Giret, S., Théron, C., Gallud, A., Maynadier, M., Gary‐Bobo, M., Garcia, M., Man, M. W. C., & Carcel, C. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201301081 · Cited by 20
Araújo, R. S., Garcia, G. M., Vilela, J. M. C., Andrade, M. S., Oliveira, L. A. M., Kano, E. K., Lange, C. C., Brito, M. A. V. P., Brandão, H. D. M., & Mosqueira, V. C. F. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110006 · Cited by 20
Design and in vitro assessment of chitosan nanocapsules for the pulmonary delivery of rifabutin
Valverde-Fraga, L., Haddad, R. H., Alrabadi, N., Sánchez, S., Remuñán‐López, C., & Csaba, N. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106484 · Cited by 19
Bhandari, M., Soria‐Carrera, H., Wohlmann, J., Dal, N. K., de la Fuente, J. M., Martín‐Rapún, R., Griffiths, G. W., & Fenaroli, F. (2023) · Biomaterials Science · doi:10.1039/d2bm01835g · Cited by 18
Wu, X., Wu, S., Yang, L., Han, J., & Han, S. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm33434h · Cited by 18
Influence of PDLA nanoparticles size on drug release and interaction with cells
Cartaxo, A. L., Costa-Pinto, A. R., Martins, A. M., Faria, S., Gonçalves, V. M. F., Tiritan, M. E., Ferreira, H., & Neves, N. M. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36563 · Cited by 18
Stimuli-Responsive Nanomachines and Caps for Drug Delivery
Kumar, N., Chen, W., Cheng, C., Deng, T., Wang, R., & Zink, J. I. (2018) · The Enzymes · doi:10.1016/bs.enz.2018.07.003 · Cited by 17
Self-citationMuguruza, A. R., Maio, A. D., Hodges, N. J., Blair, J. M. A., & Pikramenou, Z. (2023) · Nanoscale Advances · doi:10.1039/d2na00884j · Cited by 17
Roles of Nanotechnology in Diagnosis and Treatment of Tuberculosis
Cheepsattayakorn, A., & Cheepsattayakorn, R. (2013) · Journal of Nanotechnology in Diagnosis and Treatment · doi:10.12974/2311-8792.2013.01.01.3 · Cited by 17
Ali, H. R. K., & Moawad, M. S. (2016) · Journal of Bacteriology & Parasitology · doi:10.4172/2155-9597.1000264 · Cited by 17
Deng, S., Jiang, Q., Wang, Y., Lu, X., Zhu, Y., Zhang, Y., & Qiang, L. (2020) · Molecular Physics · doi:10.1080/00268976.2020.1808906 · Cited by 17
Drug-in-cyclodextrin-in-polymeric nanoparticles: A promising strategy for rifampicin administration
Abruzzo, A., Croatti, V., Zuccheri, G., Nicoletta, F. P., Sallustio, V., Corazza, E., Vitali, B., Cerchiara, T., Luppi, B., & Bigucci, F. (2022) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2022.10.001 · Cited by 17
Rajhi, A. A., Salih, W. K., Mekkey, S. M., Dhahi, H. A., Shather, A. H., Duhduh, A. A., Alamri, S., & Abbas, Z. S. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.111022 · Cited by 16
Review of inhalable nanoparticles for the pulmonary delivery of anti-tuberculosis drugs
Ramachandran, S., Prakash, P., Mohtar, N., Kumar, K. S., & Parumasivam, T. (2023) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2023.2279691 · Cited by 16
Mycobacterium tuberculosis Treatment Modalities and Recent Insights
Vijayrajratnam, S., Vinod, V., Varma, S., & Biswas, R. (2014) · Current Drug Delivery · doi:10.2174/1567201811666140619121728 · Cited by 17
Tamanna, T., Bulitta, J. B., Landersdorfer, C. B., Cashin, V. B., & Yu, A. (2015) · RSC Advances · doi:10.1039/c5ra22976f · Cited by 16
Abbadi, B. L., Rodrigues-Junior, V. S., Dadda, A. D. S., Pissinate, K., Villela, A. D., Campos, M. M., Lopes, L. G. D. F., Bizarro, C. V., Machado, P., Sousa, E. H. S., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00880 · Cited by 15
Clemens, D. L., Lee, B., Plamthottam, S., Tullius, M. V., Wang, R., Yu, C., Li, Z., Dillon, B. J., Zink, J. I., & Horwitz, M. A. (2018) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.8b00268 · Cited by 15
Self-citationMuhsen, H. O., Almayyali, A. O. M., Al-Mamoori, A. Y., & Mahmood, F. F. (2021) · Journal of Molecular Modeling · doi:10.1007/s00894-021-04711-6 · Cited by 15
Nanocarrier-based interventions for the management of MDR/XDR-TB
Mustafa, S., Pai, R. S., Singh, G., & Devi, V. K. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1009076 · Cited by 15
Silica‐based matrices: State of the art and new perspectives for therapeutic drug delivery
Andreani, T., Silva, A. M., & Souto, E. B. (2014) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1322 · Cited by 15
Kamaruzzaman, N. F., Pina, M. D. F., Chivu, A., & Good, L. (2018) · Polymers · doi:10.3390/polym10050521 · Cited by 15
Kutscher, H. L., Morse, G. D., Prasad, P. N., & Reynolds, J. L. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2576-9 · Cited by 14
Modeling nanoparticle delivery of TB drugs to granulomas
Grobler, A., Sierra, Z. P., & Viljoen, H. J. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.10.004 · Cited by 14
Laghari, M., Darwis, Y., Memon, A. H., Khan, A. A., Abdulbaqi, I. M., & Assi, R. A. (2016) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v15i1.28 · Cited by 14
Aparna, V., Shiva, M., Biswas, R., & Jayakumar, R. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.01.030 · Cited by 14
Nasab, A. S., Banafshe, H. R., Atapour, A., Mahabady, M. K., Akbari, M., Daraei, A., Mansoori, Y., & Hasan‐Abad, A. M. (2024) · Frontiers in Medical Technology · doi:10.3389/fmedt.2023.1330007 · Cited by 13
Staudinger, T., Redl, B., & Glasgow, B. J. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.02.001 · Cited by 13
Silica Nanoparticles as a Basis for Efficacy of Antimicrobial Drugs
Lykov, A. P., Гайдуль, К. В., Гольдина, И. А., Konenkov, V. I., Va, K., Lyakhov, N. Z., & Dushkin, A. V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46152-8.00025-1 · Cited by 13
Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma
Singh, S. R., Makatini, M. M., Marimuthu, T., & Choonara, Y. E. (2025) · Small · doi:10.1002/smll.202506381 · Cited by 12
Khosravi, F., Rahmani, P., & Jahanban‐Esfahlan, R. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118551 · Cited by 13
Yuan, J., Wang, B., Chen, H., Lu, X. F., Sun, W. Y., Wang, D., Lu, J., Zhao, J., Zhang, C., & Xie, Y. (2015) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-015-5437-z · Cited by 12
Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, M., & Nielsen, H. M. (2018) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12937 · Cited by 12
Canales, C. S. C., Cazorla, J. I. M., Cazorla, R. M. M., dos Santos, A. M., Duarte, J. L., Nunes, L. O. C., Reis, T. C., Salvador, L. C., Santos‐Filho, N. A., Sábio, R. M., et al. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202503964 · Cited by 11
Ribeiro, C. M., Roque‐Borda, C. A., Franzini, M. C., Manieri, K. F., Demarqui, F. M., Campos, D. L., Machado, R. T. A., da Silva, I. C., Luiz, M. T., Filippo, L. D. D., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124050 · Cited by 11
Targeting tuberculosis infection in macrophages using chitosan oligosaccharide nanoplexes
Koli, U., Nilgiriwala, K. S., Sriraman, K., Jain, R. D., & Dandekar, P. P. (2019) · Journal of Nanoparticle Research · doi:10.1007/s11051-019-4623-1 · Cited by 11
Arango-Varela, S. S., Luzardo‐Ocampo, I., Reyes‐Dieck, C., Yahia, E. M., & Celis, M. E. M. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13760 · Cited by 11
Lanni, F., Wijnant, G.-J., Xie, M., Osiecki, P., Dartois, V. A., & Sarathy, J. P. (2023) · Tuberculosis · doi:10.1016/j.tube.2023.102318 · Cited by 11
Attar, A., Bakir, C., Yüce‐Dursun, B., Demir, S., Çakmakçı, E., Danış, Ö., Birbir, M., & Ogan, A. (2017) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13066 · Cited by 11
Rushworth, J. L., Montgomery, K. S., Cao, B., Brown, R., Dibb, N. J., Nilsson, S. K., Chiefari, J., & Fuchter, M. J. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00529 · Cited by 11
Introduction to Chronic Respiratory Diseases: A Pressing Need for Novel Therapeutic Approaches
Chan, Y., Ng, S. W., Liew, H. S., Pua, L. J. W., Soon, L., Lim, J. S., Dua, K., & Chellappan, D. K. (2021) · Springer eBooks · doi:10.1007/978-981-33-6850-7_2 · Cited by 11
Macromolecular Conjugate and Biological Carrier Approaches for the Targeted Delivery of Antibiotics
Tram, N. D. T., & Ee, P. L. R. (2017) · Antibiotics · doi:10.3390/antibiotics6030014 · Cited by 11
Marlina, L. A., Hutama, A. S., Arief, I., Mazaya, M., Syafarina, I., & Saputri, W. D. (2024) · Diamond and Related Materials · doi:10.1016/j.diamond.2024.111267 · Cited by 10
Fahad, I. H., Sadoon, N., Kadhim, M. M., Alhussainy, A. A., Hachim, S. K., Abdulhussain, M. A., Abdullaha, S. A. H., & Rheima, A. M. (2022) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2022.113927 · Cited by 10
Current therapeutic delivery approaches using nanocarriers for the treatment of tuberculosis disease
Biswas, B., Misra, T. K., Ray, D., Majumder, T., Bandyopadhyay, T. K., & Bhowmick, T. K. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123018 · Cited by 10
Minimum Information for Conducting and Reporting In Vitro Intracellular Infection Assays
Subramaniam, S., Joyce, P., Ogunniyi, A. D., Dube, A., Sampson, S. L., Lehr, C., & Prestidge, C. A. (2024) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.3c00613 · Cited by 10
King, N. A., Lawton, C. R., Delargy, H. J., Smith, F., & Blundell, J. E. (1997) · QUT ePrints (Queensland University of Technology) · Cited by 10
Chiu, H., Leonhardt, H., & Bein, T. (2017) · Chemie Ingenieur Technik · doi:10.1002/cite.201700021 · Cited by 9
Boron carbide nanotube as targeted drug delivery system for melphalan anticancer drug
Zadeh, F. A., Jasim, S. A., Ansari, M. J., Bokov, D. O., Yasin, G., Thangavelu, L. P., & Derakhshandeh, M. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.118796 · Cited by 9
B3O3 monolayer an emerging 2D material in as a carrier for anticancer delivery system
Kadhim, M. M., Sahib, A. S., Hachim, S. K., Taban, T. Z., Abdullaha, S. A., & Rheima, A. M. (2022) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2022.127158 · Cited by 9
Murillo-Cremaes, N., López‐Aranguren, P., Vega, L. F., Saurina, J., Roig, A., & Domingo, C. (2014) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.27297 · Cited by 10
Injectable controlled‐release systems for the prevention and treatment of infectious diseases
Kunkel, A. A., & McHugh, K. J. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37615 · Cited by 9
Bharti, S., Singh, B., Kumar, S., Kumar, R., & Kumar, J. (2024) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-024-03928-w · Cited by 8
Nano-strategies used for combatting the scourge of tuberculosis infections
Fang, R., Jin, Y., Kong, W., Wang, H., Wang, S., Li, X., Xing, J., Zhang, Y., Yang, X., & Song, N. (2024) · Discover Immunity. · doi:10.1007/s44368-024-00007-y · Cited by 8
Trousil, J., Ulmann, V., & Hrubý, M. (2018) · Future Microbiology · doi:10.2217/fmb-2017-0296 · Cited by 8
Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections
Shin, S., Kwon, S., & Yeo, Y. (2022) · Pharmaceutical Research · doi:10.1007/s11095-022-03188-z · Cited by 8
Kiani, M. H., Imran, M., Raza, A., & Shahnaz, G. (2020) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-020-00337-w · Cited by 8
Nanoparticles: Scope in Drug Delivery
Tanwar, M., Meena, J., & Meena, L. S. (2014) · Wiley eBooks · doi:10.1002/9781118774052.ch14 · Cited by 8
Inspection the potential of B3O3 monolayer as a carrier for flutamide anticancer delivery system
Talab, M. B., muttashar, H. H., Faraj, J., Abdullaha, S. A. H., Hachim, S. K., Adel, M., Kadhim, M. M., & Rheima, A. M. (2022) · Computational and Theoretical Chemistry · doi:10.1016/j.comptc.2022.113886 · Cited by 7
Jambhrunkar, M., Maghrebi, S., Doddakyathanahalli, D., Wignall, A. D., Prestidge, C. A., & Bremmell, K. E. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041037 · Cited by 7
Pu, X., Wang, Y., Wang, X., Sang, X., Jiang, M., Qi, D., Zhao, X. H., Chen, R., Li, J., Liu, X., et al. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c01001 · Cited by 7
Functionalized Antibacterial Nanoparticles for Controlling Biofilm and Intracellular Infections
Viswanathan, A., Jayakumar, R., & Biswas, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-06115-9_10 · Cited by 7
Nanotheranostic management of drug-resistant tuberculosis
Dustachkeer, V. N. A., Nirmal, C. R., Rajadas, S. E., Saadhali, S. A., Kannayan, S., & Padmanaban, V. P. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819985-5.00004-8 · Cited by 7
Nanoparticle-Based Inhalation Therapy for Pulmonary Diseases
Yadav, D., Wairagu, P. M., Kwak, M., & Jin, J.-O. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220803103039 · Cited by 7
Hernández-Giottonini, K. Y., Arellano-Reynoso, B., Rodríguez-Córdova, R. J., de la Vega-Olivas, J., Aparicio, E. D., & Lucero‐Acuña, A. (2023) · ACS Omega · doi:10.1021/acsomega.3c07892 · Cited by 7
Khalid, S., Majeed, A., Bano, N., Ali, S. M., Ashraf, N., Gul, M., & Khan, M. I. (2024) · Molecular Physics · doi:10.1080/00268976.2024.2413008 · Cited by 6
Chawla, R., Solanki, H. S., Kheruka, S. C., Gambhir, S., Dube, V., Aggarwal, L. M., & Mishra, B. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.88 · Cited by 6
Lokhande, A. S., Panchal, F. H., Munshi, R., Madkaikar, M. R., Malshe, V. C., & Devarajan, P. V. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122729 · Cited by 6
Feyzbakhsh, H. (2025) · Egyptian Journal of Bronchology · doi:10.1186/s43168-025-00507-x · Cited by 5
Metadata
- Authors
- Clemens, D. L., Lee, B.-Y., Xue, M., Thomas, C. R., Meng, H., Ferris, D., Nel, A. E., Zink, J. I., & Horwitz, M. A.
- Affiliations
- University of California, Los Angeles (US)
- Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California, USA
- California NanoSystems Institute (US)
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2012-05
- Volume
- 56
- Issue
- 5
- Pages
- 2535-2545
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3346638
- OpenAlex
- W2021068830
- Cited by
- 260
- References
- 49
- Citations by year
- 2026: 12 · 2025: 8 · 2024: 17 · 2023: 24 · 2022: 24 · 2021: 29 · 2020: 24 · 2019: 22 · 2018: 14 · 2017: 16 · 2016: 15 · 2015: 21 · 2014: 21 · 2013: 8 · 2012: 2
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Foundation for the National Institutes of Health
- Bill and Melinda Gates Foundation
- National Cancer Institute (R01CA133697, CA 133697)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Physical Sciences › Materials Science › Materials Chemistry › Mesoporous Materials and Catalysis
- Keywords
- mesoporous silica nanoparticles, Mycobacterium tuberculosis, infected macrophages, rifampicin, isoniazid, polyethyleneimine coating, intracellular drug release, endosomal acidification, tuberculosis treatment
- MeSH terms
- Antitubercular Agents, Cell Line, Cell Survival, Cyclodextrins, Drug Compounding, Humans, Hydrogen-Ion Concentration, Isoniazid, Macrophages, Mycobacterium tuberculosis, Phagocytosis, Polyethyleneimine, Rifampin, Silicon Dioxide, Colony Count, Microbial, Porosity, Drug Delivery Systems, Microscopy, Electron, Transmission, Microbial Viability, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review