Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus
Open accessAbstract
Cephalosporin production by Streptomyces clavuligerus is regulated by some type of carbon catabolite control. Increasing concentrations of preferred carbon sources, such as glycerol and maltose, decreased production of the antibiotics. Poorer carbon sources, such as alpha-ketoglutarate and succinate, led to high specific production of cephalosporins and shifted the dynamics of fermentation to a greater degree of association with growth. The results support the concept that the phase in which a product is made by a microorganism is not a function of the particular molecule produced, but rather of the nutritional environment presented to the organism.
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S. clavuligerus is unable to assimilate glucose.
“As S. clavuligerus is unable to assimilate glucose, various compounds have been studied as C3 precursor candidates to ensure proper formulation of fermentation media and improve the yield of clavulanic acid (Aharonowitz and Demain, 1978; Garcia-Dominguez et al., 1989; Pérez-Redondo et al., 2010).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Aharonowitz and Demain, 1978
Various compounds have been studied as C3 precursor candidates to ensure proper formulation of fermentation media and improve clavulanic acid yield.
“As S. clavuligerus is unable to assimilate glucose, various compounds have been studied as C3 precursor candidates to ensure proper formulation of fermentation media and improve the yield of clavulanic acid (Aharonowitz and Demain, 1978; Garcia-Dominguez et al., 1989; Pérez-Redondo et al., 2010).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Aharonowitz and Demain, 1978
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“clavuligerus is unable to assimilate glucose, various compounds have been studied as C3 precursor candidates to ensure proper formulation of fermentationmedia and improve the yield of clavulanic acid (Aharonowitz and Demain, 1978; Garcia-Dominguez et al., 1989; Pérez-Redondo et al., 2010).”
BackgroundSaudagar, P. S., & Singhal, R. S. (2007) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-007-9030-x · Cited by 26 · see citing works
- Authors
- Aharonowitz, Y., & Demain, A. L.
- Affiliations
- Massachusetts Institute of Technology (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1978-08
- Volume
- 14
- Issue
- 2
- Pages
- 159-164
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC352426
- OpenAlex
- W1977592577
- Cited by
- 141
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 6
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture
- Eli Lilly and Company
- Merck Sharp and Dohme
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- cephalosporin production, Streptomyces clavuligerus, carbon source effects, glycerol, maltose, alpha-ketoglutarate, succinic acid, fermentation dynamics, antibiotic biosynthesis, nutritional environment
- MeSH terms
- Amino Acids, Carbon, Carboxylic Acids, Cephalosporins, Glycerol, Streptomyces, Carbohydrate Metabolism
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