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Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors
Open accessAbstract
The minimum bactericidal concentration of oxacillin for Staphylococcus aureus was shown to be considerably influenced by technical and definitional factors, particularly by the survival of some organisms on the walls of test tubes and by the growth phase of the inoculum. Attention to technical detail greatly improved reproducibility, and log-phase cultures of all strains showed greater than 99.9% killing in 24 h, at or close to the minimum inhibitory concentration, including eight strains described as tolerant. Some strains showed the paradoxical phenomenon of having more survivors in higher concentrations above the minimum bactericidal concentration. An accepted reference minimum bactericidal concentration procedure is needed for establishing clinical correlates and for a review of endpoint criteria. Routine minimum bactericidal concentration tests on S. aureus should be interpreted with great caution.
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Cited by
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Balaban, N. Q., Helaine, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., et al. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0196-3 · Cited by 1,313
Pankey, G. A., & Sabath, L. D. (2004) · Clinical Infectious Diseases · doi:10.1086/381972 · Cited by 1,201
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Doern, C. D. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01121-14 · Cited by 431
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Pfaller, M. A., Sheehan, D. J., & Rex, J. H. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.268-280.2004 · Cited by 352
Metadata
- Authors
- Taylor, P. C., Schoenknecht, F. D., Sherris, J. C., & Linner, E. C.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1983-01
- Volume
- 23
- Issue
- 1
- Pages
- 142-150
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W1985432986
- Cited by
- 213
- References
- 0
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Taylor, P. C., Schoenknecht, F. D., Sherris, J. C., & Linner, E. C. (1983). Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.23.1.142
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