The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
When Does 2 Plus 2 Equal 5? A Review of Antimicrobial Synergy Testing
Open accessAbstract
In this age of emerging antibiotic resistance, limited therapeutic options exist for treating multidrug-resistant organisms. Combination therapy is commonly employed to manage these infections despite little laboratory guidance as to the efficacy of this approach. Synergy testing methods have been used to assess the interaction of antibiotic combinations in vitro . This review will discuss the four primary methods used to assess synergy, as well as the data that exist for testing of cystic fibrosis. In the final analysis, this review concludes that there is not enough evidence to endorse synergy testing for routine clinical use.
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Citations
Cites
Combination Therapy for Treatment of Infections with Gram-Negative Bacteria
Tamma, P. D., Cosgrove, S. E., & Maragakis, L. L. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05041-11 · Cited by 836
Cystic Fibrosis Pulmonary Guidelines: Treatment of Pulmonary Exacerbations
Flume, P. A., Mogayzel, P. J., Robinson, K. A., Goss, C. H., Rosenblatt, R. L., Kuhn, R. J., Marshall, B. C., & and the Clinical Practice Guidelines for Pulmonary Therapies Committee (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200812-1845pp · Cited by 738
White, R. L., Burgess, D. S., Manduru, M., & Bosso, J. A. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.8.1914 · Cited by 721
Inadequate Antimicrobial Treatment: An Important Determinant of Outcome for Hospitalized Patients
Kollef, M. H. (2000) · Clinical Infectious Diseases · doi:10.1086/314079 · Cited by 635
Has antifungal susceptibility testing come of age
Rex, J. H., & Pfaller, M. A. (2002) · Clinical Infectious Diseases · doi:10.1086/342384 · Cited by 361
Orhan, G., Bayram, A., Zer, Y., & Balci, I. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.1.140-143.2005 · Cited by 357
Aaron, S. D., Ferris, W., Henry, D. A., Speert, D. P., & MacDonald, N. E. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.9907147 · Cited by 240
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Cited by
A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides
Browne, K., Chakraborty, S., Chen, R., Willcox, M. D., Black, D. S., Walsh, W. R., & Kumar, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197047 · Cited by 482
The rapid spread of carbapenem-resistant Enterobacteriaceae
Potter, R. F., D’Souza, A. W., & Dantas, G. (2016) · Drug Resistance Updates · doi:10.1016/j.drup.2016.09.002 · Cited by 403
Ramalingam, R., Dhand, C., Mayandi, V., Leung, C. M., Ezhilarasu, H., Karuppannan, S. K., Prasannan, P., Ong, S. T., Sunderasan, N., Kaliappan, I., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c20642 · Cited by 115
Dominguez, J., Mendes, A. I., Pacheco, A. R., Peixoto, M. J., Pedrosa, J., & Fraga, A. G. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1266261 · Cited by 4
Metadata
- Authors
- Doern, C. D.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2014-12
- Volume
- 52
- Issue
- 12
- Pages
- 4124-4128
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2167896918
- Cited by
- 431
- References
- 20
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Doern, C. D. (2014). When Does 2 Plus 2 Equal 5? A Review of Antimicrobial Synergy Testing. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.01121-14
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
