Cited by 61Nanoparticle-Based Drug DeliveryAntimicrobial Resistance in StaphylococcusAntibiotics Pharmacokinetics and Efficacy

Enhanced liposome-mediated activity of piperacillin against staphylococci

Open access
Nacucchio, M C, Bellora, M J, Sordelli, D O, D'Aquino, M·1985·Antimicrobial Agents and Chemotherapy

Abstract

This study showed that encapsulation of the beta-lactam antibiotic piperacillin (PIP) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) protected the drug from hydrolysis by staphylococcal beta-lactamase. This was demonstrated by growth inhibition of Staphylococcus aureus in the presence of the liposomal preparation containing PIP at a 50% MIC. Growth inhibition was also seen when exogenous beta-lactamase was added. Furthermore, adsorption of PIP onto the surface of liposomes containing buffer conferred a significant degree of protection against enzymatic hydrolysis of the drug, thus enhancing its antistaphylococcal activity.

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Crossref · 10.1128/aac.27.1.137

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16 of 16 references verified0 citation errors · 0 not checkable

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Authors
Nacucchio, M. C., Bellora, M. J., Sordelli, D. O., & D'Aquino, M.
Affiliations
  • Universidad de Buenos Aires (AR)
  • Georgetown University Medical Center (US)
Venue
Antimicrobial Agents and Chemotherapy
Published
1985-01
Volume
27
Issue
1
Pages
137-139
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2035833314
Cited by
61
References
16
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
1.54
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
Keywords
piperacillin, liposomes, Staphylococcus aureus, beta-lactamase, antibiotic hydrolysis, drug encapsulation, phosphatidylcholine, cholesterol, liposomal drug delivery, antibacterial activity, beta-lactam antibiotics
MeSH terms
beta-Lactamases, Cholesterol, Liposomes, Phosphatidylcholines, Piperacillin, Staphylococcus aureus, Time Factors

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