Enhanced liposome-mediated activity of piperacillin against staphylococci
Open accessAbstract
This study showed that encapsulation of the beta-lactam antibiotic piperacillin (PIP) by liposomes prepared with phosphatidylcholine and cholesterol (1:1) protected the drug from hydrolysis by staphylococcal beta-lactamase. This was demonstrated by growth inhibition of Staphylococcus aureus in the presence of the liposomal preparation containing PIP at a 50% MIC. Growth inhibition was also seen when exogenous beta-lactamase was added. Furthermore, adsorption of PIP onto the surface of liposomes containing buffer conferred a significant degree of protection against enzymatic hydrolysis of the drug, thus enhancing its antistaphylococcal activity.
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- Authors
- Nacucchio, M. C., Bellora, M. J., Sordelli, D. O., & D'Aquino, M.
- Affiliations
- Universidad de Buenos Aires (AR)
- Georgetown University Medical Center (US)
- ORCID
- Sordelli, D O
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1985-01
- Volume
- 27
- Issue
- 1
- Pages
- 137-139
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC176221
- OpenAlex
- W2035833314
- Cited by
- 61
- References
- 16
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- piperacillin, liposomes, Staphylococcus aureus, beta-lactamase, antibiotic hydrolysis, drug encapsulation, phosphatidylcholine, cholesterol, liposomal drug delivery, antibacterial activity, beta-lactam antibiotics
- MeSH terms
- beta-Lactamases, Cholesterol, Liposomes, Phosphatidylcholines, Piperacillin, Staphylococcus aureus, Time Factors
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