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In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibiotic
Open accessAbstract
The in vitro activity of LY 146032, a cyclic lipopeptide antibiotic belonging to the class of agents designated A21978C, was compared with those of vancomycin, cefpirome, cefotaxime, and clindamycin against selected gram-positive bacteria. The new drug inhibited all staphylococcal isolates, including methicillin-resistant strains, at concentrations of less than or equal to 1.0 microgram/ml. The activity of LY 146032 was comparable to that of vancomycin against most streptococci, but the latter demonstrated greater potency against Streptococcus faecium and penicillin-resistant strains of pneumococci and viridans group streptococci. LY 146032 was markedly less active than vancomycin against Listeria monocytogenes (MICs for 90% of strains tested, 16 and 1.0 microgram/ml, respectively). The activity of LY 146032 was enhanced as the concentration of calcium in the test medium was increased. MBCs were within eightfold of the MIC for each of 12 strains tested. In a rat model of enterococcal endocarditis, the administration of LY 146032 resulted in increased survival and a reduction in the bacterial titer within cardiac vegetations compared with untreated control animals.
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Citations
Cited by
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Lobritz, M. A., Belenky, P., Porter, C. B. M., Gutierrez, A., Yang, J. H., Schwarz, E. G., Dwyer, D. J., Khalil, A. S., & Collins, J. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509743112 · Cited by 773
Gan, B. H., Gaynord, J., Rowe, S. M., Deingruber, T., & Spring, D. R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00729c · Cited by 511
Straus, S. K., & Hancock, R. E. W. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.02.009 · Cited by 446
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Baltz, R. H., Miao, V., & Wrigley, S. K. (2005) · Natural Product Reports · doi:10.1039/b416648p · Cited by 393
Metadata
- Authors
- Eliopoulos, G. M., Willey, S., Reiszner, E., Spitzer, P. G., Caputo, G., & Moellering, R. C.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1986-10
- Volume
- 30
- Issue
- 4
- Pages
- 532-535
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W1967604884
- Cited by
- 173
- References
- 0
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Eliopoulos, G. M., Willey, S., Reiszner, E., Spitzer, P. G., Caputo, G., & Moellering, R. C. (1986). In vitro and in vivo activity of LY 146032, a new cyclic lipopeptide antibiotic. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.30.4.532
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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