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Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter
Open accessAbstract
The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.
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Citations
Cited by
Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux
Nikaido, H. (1994) · Science · doi:10.1126/science.8153625 · Cited by 1,540
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 820
Multidrug evolutionary strategies to reverse antibiotic resistance
Baym, M., Stone, L. K., & Kishony, R. (2016) · Science · doi:10.1126/science.aad3292 · Cited by 710
Multidrug Efflux Pumps in Staphylococcus aureus: an Update
Costa, S. S., Viveiros, M., Amaral, L., & Couto, I. (2013) · The Open Microbiology Journal · doi:10.2174/1874285801307010059 · Cited by 409
Metadata
- Authors
- Neyfakh, A. A., Borsch, C. M., & Kaatz, G. W.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1993-01
- Volume
- 37
- Issue
- 1
- Pages
- 128-129
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2069814511
- Cited by
- 361
- References
- 0
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Neyfakh, A. A., Borsch, C. M., & Kaatz, G. W. (1993). Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.37.1.128
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