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Cited by 1,540

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

Nikaido, Hiroshi·1994·Science
DOI 10.1126/science.8153625
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Abstract

Some species of bacteria have low-permeability membrane barriers and are thereby "intrinsically" resistant to many antibiotics; they are selected out in the multitude of antibiotics present in the hospital environment and thus cause many hospital-acquired infections. Some strains of originally antibiotic-susceptible species may also acquire resistance through decreases in the permeability of membrane barriers. Another mechanism for preventing access of drugs to targets is the membrane-associated energy-driven efflux, which plays a major role in drug resistance, especially in combination with the permeation barrier. Recent results indicate the existence of bacterial efflux systems of extremely broad substrate specificity, in many ways reminiscent of the multidrug resistance pump of mammalian cells. One such system seems to play a major role in the intrinsic resistance of Pseudomonas aeruginosa , a common opportunistic pathogen. As the pharmaceutical industry succeeds in producing agents that can overcome specific mechanisms of bacterial resistance, less specific resistance mechanisms such as permeability barriers and multidrug active efflux may become increasingly significant in the clinical setting.

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Metadata

Authors
Nikaido, H.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-04-15
Volume
264
Issue
5157
Pages
382-388
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8153625
OpenAlex
W2078785671
Cited by
1,540
References
79
FWCI
39.76
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux. https://app.cochat.ai/papers/10.1126/science.8153625
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Nikaido, H. (1994). Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux. Science. https://doi.org/10.1126/science.8153625

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.