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Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene
Open accessAbstract
The bis(monosuccinimide) derivative of p,p'-bis(2-aminoethyl)diphenyl-C60 (compound 1), prepared by the fulleroid route, is active against human immunodeficiency virus type 1 (HIV-1) and HIV-2 (50% effective concentration [EC50] averaging approximately 6 microM) in acutely or chronically infected human lymphocytes and is active in vitro against 3'-azido-3'-deoxythymidine-resistant HIV-1 (EC50, approximately 3 microM). The virucidal properties of compound 1 were confirmed by virus inactivation assays. Compound 1 was noncytotoxic up to 100 microM in peripheral blood mononuclear cells and H9, Vero, and CEM cells. In cell-free assays, whereas the fullerene showed comparable activity against HIV-1 reverse transcriptase and DNA polymerase alpha (50% inhibitory concentration of approximately 5 microM), it demonstrated selective activity against HIV-1 protease.
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Kroto, H. W., Allaf, A. W., & Balm, S. P. (1991) · Chemical Reviews · doi:10.1021/cr00006a005 · Cited by 1,088
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Klaine, S. J., Alvarez, P. J. J., Batley, G. E., Fernandes, T. F., Handy, R. D., Lyon, D. Y., Mahendra, S., McLaughlin, M. J., & Lead, J. R. (2008) · Environmental Toxicology and Chemistry · doi:10.1897/08-090.1 · Cited by 2,764
Yamago, S., Tokuyama, H., Nakamura, E., Kikuchi, K., Kananishi, S., Sueki, K., Nakahara, H., Enomoto, S., & Ambe, F. (1995) · Chemistry & Biology · doi:10.1016/1074-5521(95)90219-8 · Cited by 375
Metadata
- Authors
- Schinazi, R. F., Sijbesma, R., Srdanov, G., Hill, C. L., & Wudl, F.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1993-08
- Volume
- 37
- Issue
- 8
- Pages
- 1707-1710
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2022651747
- Cited by
- 194
- References
- 1
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Schinazi, R. F., Sijbesma, R., Srdanov, G., Hill, C. L., & Wudl, F. (1993). Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.37.8.1707
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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