The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mechanism of electrical enhancement of efficacy of antibiotics in killing biofilm bacteria
Open accessAbstract
The bioelectric effect, in which electric fields are used to enhance the efficacy of biocides and antibiotics in killing biofilm bacteria, has been shown to reduce the very high concentrations of these antibacterial agents needed to kill biofilm bacteria to levels very close to those needed to kill planktonic (floating) bacteria of the same species. In this report, we show that biofilm bacteria are readily killed by an antibiotic on all areas of the active electrodes and on the surfaces of conductive elements that lie within the electric field but do not themselves function as electrodes. Considerations of electrode geometry indicate that very low (< 100 microA/cm2) current densities may be effective in this electrical enhancement of antibiotic efficacy against biofilm bacteria, and flow experiments indicate that this bioelectric effect does not appear to depend entirely on the possible local electrochemical generation of antibacterial molecules or ions. These data are expected to facilitate the use of the bioelectric effect in the prevention and treatment of device-related bacterial infections that are caused by bacteria that grow in biofilms and thereby frustrate antibiotic chemotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bacterial Biofilms in Nature and Disease
Costerton, J. W., Cheng, K. J., Geesey, G. G., Ladd, T. I., Nickel, J. C., Dasgupta, M., & Marrie, T. J. (1987) · Annual Review of Microbiology · doi:10.1146/annurev.mi.41.100187.002251 · Cited by 3,145
Self-citationThe Electrostatic Properties of Membranes
McLaughlin, S. (1989) · Annual Review of Biophysics and Biophysical Chemistry · doi:10.1146/annurev.bb.18.060189.000553 · Cited by 1,071
Electroporation and Electrofusion in Cell Biology
(1989) · Springer eBooks · doi:10.1007/978-1-4899-2528-2 · Cited by 942
Nickel, J. C., Ruseska, I., Wright, J. B., & Costerton, J. W. (1985) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.27.4.619 · Cited by 889
Self-citationReversible electrical breakdown of lipid bilayers: formation and evolution of pores
Glaser, R. W., Leikin, S. L., Chernomordik, L. V., Pastushenko, V. F., & Sokirko, A. I. (1988) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(88)90202-7 · Cited by 607
ALTERATIONS IN OUTER MEMBRANE PERMEABILITY
Hancock, R. E. W. (1984) · Annual Review of Microbiology · doi:10.1146/annurev.mi.38.100184.001321 · Cited by 564
Resistance of bacterial biofilms to antibiotics a growth-rate related effect?
BROWN, M. R. W., ALLISON, D. G., & GILBERT, P. (1988) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/22.6.777 · Cited by 545
Cevc, G. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90015-5 · Cited by 522
Gilbert, P., Collier, P. J., & Brown, M. R. (1990) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.34.10.1865 · Cited by 403
Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria
Eng, R. H., Padberg, F. T., Smith, S. M., Tan, E. N., & Cherubin, C. E. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.9.1824 · Cited by 350
Cited by
Understanding biofilm resistance to antibacterial agents
Davies, D. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1008 · Cited by 2,781
Dental biofilms: difficult therapeutic targets
SOCRANSKY, S. S., & HAFFAJEE, A. D. (2002) · Periodontology 2000 · doi:10.1034/j.1600-0757.2002.280102.x · Cited by 1,273
Microbial Biofilms in the Food Industry—A Comprehensive Review
Carrascosa, C., Raheem, D., Ramos, F., Saraiva, A., & Raposo, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18042014 · Cited by 459
Photodynamic therapy in the control of oral biofilms
Soukos, N. S., & Goodson, J. M. (2011) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00346.x · Cited by 342
Current and Recent Advanced Strategies for Combating Biofilms
Sadekuzzaman, M., Yang, S., Mizan, M. F. R., & Ha, S. D. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12144 · Cited by 276
Metadata
- Authors
- Costerton, J. W., Ellis, B., Lam, K., Johnson, F., & Khoury, A. E.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1994-12
- Volume
- 38
- Issue
- 12
- Pages
- 2803-2809
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2150823065
- Cited by
- 339
- References
- 27
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanism of electrical enhancement of efficacy of antibiotics in killing biofilm bacteria. https://app.cochat.ai/papers/10.1128/aac.38.12.2803
- The paper
- Costerton, J. W., Ellis, B., Lam, K., Johnson, F., & Khoury, A. E. (1994). Mechanism of electrical enhancement of efficacy of antibiotics in killing biofilm bacteria. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.38.12.2803
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
