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Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection
Open accessAbstract
Licochalcone A, isolated from Chinese licorice roots, inhibited the in vitro growth of both chloroquine-susceptible (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains in a [3H]hypoxanthine uptake assay. The growth inhibition of the chloroquine-resistant strain by licochalcone A was similar to that of the chloroquine-susceptible strain. To examine the activity of licochalcone A on the different asexual blood stages of the parasite, licochalcone A was added to highly synchronized cultures containing rings, trophozoites, and schizonts. The growth of the parasites at all stages was inhibited by licochalcone A. The in vivo activity of licochalcone A was tested in a mouse model of infection with P. yoelii. Licochalcone A administered either intraperitoneally or orally for 3 to 6 days protected the mice from the otherwise lethal P. yoelii infection. These results demonstrate that licochalcone A exhibits potent antimalarial activity and might be developed into a new antimalarial drug.
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Cited by
A review of anti-infective and anti-inflammatory chalcones
Nowakowska, Z. (2007) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2006.09.019 · Cited by 1,084
Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review
Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P. (2018) · Phytotherapy Research · doi:10.1002/ptr.6178 · Cited by 804
Recent developments in biological activities of chalcones: A mini review
Singh, P., Anand, A., & Kumar, V. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.08.033 · Cited by 710
Natural products as antiparasitic drugs
Kayser, O., Kiderlen, A. F., & Croft, S. L. (2003) · Parasitology Research · doi:10.1007/s00436-002-0768-3 · Cited by 373
Chalcones: Synthetic Chemistry Follows Where Nature Leads
Jasim, H. A., Nahar, L., Jasim, M. A., Moore, S. A., Ritchie, K. J., & Sarker, S. D. (2021) · Biomolecules · doi:10.3390/biom11081203 · Cited by 167
Metadata
- Authors
- Chen, M., Theander, T. G., Christensen, S. B., Hviid, L., Zhai, L., & Kharazmi, A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1994-07
- Volume
- 38
- Issue
- 7
- Pages
- 1470-1475
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W1987213888
- Cited by
- 253
- References
- 0
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, M., Theander, T. G., Christensen, S. B., Hviid, L., Zhai, L., & Kharazmi, A. (1994). Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.38.7.1470
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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