Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review

Pastorino, Giulia; Cornara, Laura; Soares, Sónia; Rodrigues, Francisca; Oliveira, M. Beatriz P.P.

doi:10.1002/ptr.6178

Cited by 831Pharmacological Effects of Natural CompoundsNatural product bioactivities and synthesisMedicinal Plant Research

Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review

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Pastorino, Giulia, Cornara, Laura, Soares, Sónia, Rodrigues, Francisca, Oliveira, M. Beatriz P.P.·2018·Phytotherapy Research

DOI 10.1002/ptr.6178PMC PMC7167772

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Abstract

In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β‐glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti‐inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra . Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well‐being.

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Glabridin is the principal isoflavane identified in G. glabra roots, ranging between 0.08% and 0.35% of dry weight.
“Glabridin is the principal isoflavane identified, ranging between 0.08% and 0.35% of G. glabra roots dry weight [4,17].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [4]
Section 3 (Phytochemistry and Bioactive Compounds; page unavailable) identifies glabridin as the principal compound and gives the claimed range of 0.08%–0.35% of root dry weight. It calls glabridin the principal “isoflavone,” however, not the principal “isoflavane” as the citing sentence states. (LLM, conf=0.90)
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Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
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A REVIEW ARTICLE ON LICORICE (GLYCYRRHIZA GLABRA LINN)
Sandhya karumanchi, D. A. P. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.14237432
Review on Licorice Plant (Jaist Madhu)
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A review on pharmacological activities and traditional uses of Glycyrrhiza glabra (licorice)
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GLYCYRRHIZA GLABRA (LIQUORICE): A COMPREHENSIVE REVIEW OF ITS PHYTOCHEMISTRY, TRADITIONAL USES AND PHARMACOLOGICAL ACTIVITIES
Selva Guhan S.1, M. R. V. B. 1. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22211743
Phytochemistry and Pharmacological Studies of Glycyrrhiza glabra: A Medicinal Plant Review
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Authors: Pastorino, G., Cornara, L., Soares, S., Rodrigues, F., & Oliveira, M. B. P. P.
Affiliations: University of Genoa (IT)
National Research Council (IT)
Universidade do Porto (PT)
Corresponding author: Rodrigues, Francisca
ORCID: Cornara, Laura
Soares, Sónia
Rodrigues, Francisca
Oliveira, M. Beatriz P.P.
Venue: Phytotherapy Research
Publisher: Wiley
Published: 2018-08-17
Volume: 32
Issue: 12
Pages: 2323-2339
ISSN: 0951-418X (ISSN-L)
1099-1573
DOI: 10.1002/ptr.6178
PMC: PMC7167772
OpenAlex: W2886070608
Cited by: 804
References: 157
Citations by year: 2026: 103 · 2025: 122 · 2024: 143 · 2023: 114 · 2022: 129 · 2021: 103 · 2020: 67 · 2019: 21 · 2018: 1 · 2017: 1
FWCI: 9.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Phytotherapy Research (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Funders: Ministério da Educação e Ciência
Fundação para a Ciência e a Tecnologia (Operação NORTE‐01‐0145‐FEDER‐000011)
European Regional Development Fund (NORTE‐01‐0145‐FEDER‐000011)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords: licorice, phytochemicals, glycyrrhizin, 18β-glycyrrhetinic acid, isoflavones, antibacterial activity, anti-inflammatory activity, antiviral activity, antioxidant activity, antidiabetic activity, toxicity, ethnopharmacology, nutraceuticals, traditional medicine
MeSH terms: Animals, Anti-Bacterial Agents, Antioxidants, Antiviral Agents, Enzyme Inhibitors, Glycyrrhiza, Humans, Hypoglycemic Agents, Medicine, Traditional, Plant Extracts, Glycyrrhizic Acid, Ethnopharmacology, Phytochemicals

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Liquorice ( Glycyrrhiza glabra ): A phytochemical and pharmacological review

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