Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Towbin, H., Staehelin, T., & Gordon, J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4350 · Cited by 53,218

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,724

[6] Use of T7 RNA polymerase to direct expression of cloned genes

Studier, F. W., Rosenberg, A. H., Dunn, J. J., & Dubendorff, J. W. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)85008-c · Cited by 6,562

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

Studier, F. W., & Moffatt, B. A. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90385-2 · Cited by 6,385

Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance

Speer, B. S., Shoemaker, N. B., & Salyers, A. A. (1992) · Clinical Microbiology Reviews · doi:10.1128/cmr.5.4.387 · Cited by 511

Tetracyclines, molecular and clinical aspects

Chopra, I., Hawkey, P. M., & Hinton, M. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/29.3.245 · Cited by 423

Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution

Girard, A., GIRARD, D., English, A. R., Gootz, T. D., Cimochowski, C. R., FAIELLA, J. A., Haskell, S. L., & Retsema, J. A. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.12.1948 · Cited by 321

[41] Reconstitution of ribosomes from subribosomal components

Traub, P., Mizushima, S.-I., Lowry, C. V., & Nomura, M. (1971) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(71)20043-4 · Cited by 290

Mechanism of quinolone inhibition of DNA gyrase

Shen, L. L., Kohlbrenner, W. E., Weigl, D., & Baranowski, J. L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81708-8 · Cited by 215

Carbapenems vs tigecycline for the treatment of complicated intra-abdominal infections

Chen, L., Liang, X., Jiang, J., Li, X., & Li, Y. (2019) · Medicine · doi:10.1097/md.0000000000017436 · Cited by 12

Antibiotic therapeutic options for infections caused by drug-resistant Gram-positive cocci

Banwan, K., Senok, A. C., & Rotimi, V. O. (2009) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2009.04.003 · Cited by 10

Bactericidal and Bacteriostatic Antibiotics

Patil, S. M., & Patel, P. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99546 · Cited by 9

Chapter 11. New Approaches and Agents to Overcome Bacterial Resistance

Domagala, J. M., & Sanchez, J. P. (1997) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)61469-4 · Cited by 9

A Review of Tigecycline

French, G. L. (2008) · Journal of Chemotherapy · doi:10.1179/joc.2008.20.supplement-1.3 · Cited by 8

Target Modification As A Mechanism Of Antimicrobial Resistance

Hooper, D. C. (2001) · CRC Press eBooks · doi:10.1201/9780824744939.ch7 · Cited by 8

Case studies in current drug development: ‘glycylcyclines’

Sum, P. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.06.009 · Cited by 7

Tigecycline: First class glycylcycline

Jones, C. H., & Petersen, P. J. (2006) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2006.06.009 · Cited by 7

Tetracyclines

Bradford, P. A., & Jones, C. H. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1400-1_5 · Cited by 5

ComparativeIn VitroActivity of Tigecycline Against Aerobic and Facultative Isolates Recovered from Hospitalized Patients: An Argentinean Multicenter Study

Casellas, J. M., Bantar, C., & Duret, F. (2007) · Journal of Chemotherapy · doi:10.1179/joc.2007.19.5.482 · Cited by 5

Omadacycline, a Magic Antibiotics for Bacterial Infections

Rahman, M. S., & Koh, Y. S. (2018) · Journal of Bacteriology and Virology · doi:10.4167/jbv.2018.48.3.109 · Cited by 5

Resistance of Gram-Negative Bacilli to Antimicrobials

Bradford, P. A., & Dean, C. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-72418-8_4 · Cited by 4

Chapter 22 New Developments in Antibacterial Drug R&D

Frechette, R. F. (2007) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(07)42022-x · Cited by 4

Nuevos antibióticos frente a grampositivos: linezolid, tigeciclina, daptomicina, dalbavancina, telavancina, ceftobiprole

Soriano, F. G. (2008) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1157/13123562 · Cited by 4

Ocular penetration of topically applied 1% tigecycline in a rabbit model

Sakarya, Y., Sakarya, R., Özçimen, M., Göktaş, S., Özçimen, S., Alpfidan, İ., Ivacık, I. S., Erdoğan, E., Çetinkaya, S., & Bukus, A. (2017) · International Journal of Ophthalmology · doi:10.18240/ijo.2017.05.03 · Cited by 3

In vitro Activity of Tigecycline Against Clinical Isolates of Gram−Positive and Gram−Negative Bacteria Displaying Different Resistance Phenotypes Aktywność in vitro tigecykliny wobec izolatów klinicznych bakterii Gram−dodatnich i Gram−ujemnych o różnych fenotypach oporności

Franiczek, R., Dolna, I., Dworniczek, E., & Seniuk, A. (2008) · Cited by 3

Inhibitors of the 30S Ribosomal Subunit Aminoglycosidesand Tetracyclines

Mascaretti, O. A. (2014) · ASM Press eBooks · doi:10.1128/9781555817794.ch17 · Cited by 3

Patents on tetracycline and tetracycline derivatives as antimicrobials: January 1998 ? October 2002

Podlogar, B. L., Ohemeng, K. A., & Barrett, J. F. (2003) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.13.4.467 · Cited by 3

Antibacterial Drugs

Chan, A., Cross, J. T., He, Y. Q., Lippa, B., & Ryan, D. (2013) · Drug Discovery · doi:10.1002/9781118354483.ch10 · Cited by 4

Tetracycline Resistance Determinants in Gram-Positive Bacteria

McMurry, L. M., & Levy, S. B. (2014) · ASM Press eBooks · doi:10.1128/9781555816513.ch64 · Cited by 2

Interactions of tetracyclines with RNA

Berens, C. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8306-1_7 · Cited by 2

La tigeciclina, el primer antibiótico de una nueva clase: las glicilciclinas

Bosó, V., Sánchez, E. R., Salavert, M., Martí, V. H., & Andrés, J. L. P. (2007) · Revista española de quimioterapia. Suplemento · Cited by 2

Resistencias bacterianas y un nuevo antibiótico: la tigeciclina

Gobernado, M. (2006) · Hispana · Cited by 2

NEW ANTIMICROBIALS

Mikhail, M., & Weinberg, J. M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511778339.004 · Cited by 1

Koagulase-negative Staphylokokken als multiresistente Krankheitserreger Epidemiologie, Eigenschaften und neue Behandlungsoptionen

Amt, Ü. (2007) · Cited by 1

SKIN AND SOFT TISSUE INFECTIONS

Ghafur, A. K., & Ps, S. (2015) · Cited by 1

Resistance of Gram-negative Bacilli to Antimicrobials

Dean, C. R., Pascale, G. D., & Benton, B. M. (2018) · Springer eBooks · doi:10.1007/978-3-319-78538-7_4 · Cited by 1

Five-Years Tigecycline Experience an Analysis of Real-Life Data

Temoçin, F., Tülek, N., Hekimoğlu, Ş., İlgar, T., Bulut, C., Erdinç, F. Ş., Ertem, G. T., Hatipoğlu, Ç. A., & KINIKLI, S. (2018) · Medical Bulletin of Haseki · doi:10.4274/haseki.42713 · Cited by 1

Resistance to Other Agents

Strahilevitz, J., & Hooper, D. C. (2009) · Wiley eBooks · doi:10.1002/9781444308464.ch10 · Cited by 1

Biological Aspects of Metal Enolates

Ming, L. (2010) · Patai's chemistry of functional groups · doi:10.1002/9780470682531.pat0427 · Cited by 1

Supplementary Materials for The Innate Growth Bistability and Fitness Landscapes of Antibiotic- Resistant Bacteria

Deris, J. B., Kim, M., Zhang, Z., Okano, H., Hermsen, R., Groisman, A., & Terence Hwa, B. (2013) · Cited by 1

Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery

Jones, J. A. (2019) · doi:10.21007/etd.cghs.2019.0491 · Cited by 1

Clinical Aspects of Multi-Drug Resistant Enterococci

Contreras, G., & Arias, C. A. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1400-1_19

Therapeutic Agents Acting on RNA Targets

Rife, J. P. (2010) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc025.pub2

Biosensors Micro and Nano Integration

Doraiswami, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-46283-7_11

In vitro antimicrobial activity of tigecycline against Gram negative and Gram positive pathogens collected in Northen Italy (T.E.S.T. program 2010)

Coppo, E., Barbieri, R., Marchese, A. E., & Debbia, E. A. (2011) · Microbiologia medica · doi:10.4081/mm.2011.2386

Three Steps to Antibiotic Resistance? The Development of Tigecycline Resistance in the Gram-Negative Bacteria Escherichia coli and Salmonella typhimurium

Neuvonen, M.-M. (2011)

Tepecik Eğitim ve Araştırma Hastanesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Laboratuvarında İzole Edilen Bakterilerin Tigesiklin ve Diğer Antibiyotiklere Duyarlılığının İncelenmesi

Köse, Ş., Ece, G. T., Türken, M., Gözaydın, A., & Tatar, B. (2012) · DergiPark (Istanbul University)

Mycobacteriawith Nontuberculous Resistance Mechanisms, and Therapy of Antimicrobial Susceptibility Testing, Drug

Wallace, Brown‐Elliott, B. A., Nash, K. A., & Richard, J. (2012)

Tigeciclina, la primera glicilciclina Tigecycline, the first glycylcycline

Curcio, D., & Istúriz, R. (2006)

Macrolides, Ketolides, and Glyc ylcy clines: Azithromycin, Clarithromycin, Telithromycin,

Zuckerman, J., & Qamar, F. (2009)

Mechanisms of Action of Antibacterial Agents

Buensalido, J. A. L., DeMarco, C. E., & Lerner, S. (2015) · CRC Press eBooks · doi:10.1201/b17871-13

Investigation of the Kinetics of Tet(O)-mediated Tetracycline Resistance

Li, J. (2010) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3fd69

Faculty Opinions recommendation of The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria.

Nester, G. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718190816.793489311

Therapeutic Agents Acting on RNA Targets

Rife, J. P. (2003) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc025

Tetracyclines

Sum, P. (2004) · Kirk-Othmer Encyclopedia of Chemical Technology · doi:10.1002/0471238961.2005201808120122.a01.pub2

Faculty Opinions recommendation of The innate growth bistability and fitness landscapes of antibiotic-resistant bacteria.

Koelle, K. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718190816.793487740

Molecular determinants of bacterial antimicrobial efflux by the Major Facilitator Superfamily members CraA and TetA from Acinetobacter baumannii.

Foong, W. E. (2021) · doi:10.21248/gups.61975

Target Modification as a Mechanism of Antimicrobial Resistance

Hooper, D. C. (2007) · CRC Press eBooks · doi:10.1201/9781420008753.ch7

Tetraciclinas. Glicilciclinas

N’Guyen, Y., & Baumard, S. (2013) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(12)64067-7

Anti-inflammatory and pro-resolving role of mast cells during resolution of local inflammation.

Kornstädt, L. (2021) · doi:10.21248/gups.61805

Tétracyclines. Glycylcyclines

N’Guyen, Y., & Baumard, S. (2012) · EMC - Traité de médecine AKOS · doi:10.1016/s1634-6939(12)45853-7

Tigecycline. Prospects of its application in the fight against polyresistant strains

Kotaeva, Е. S., & Maksimov, M. L. (2022) · Glavvrač (Chief Medical Officer) · doi:10.33920/med-03-2206-27

Newer antimicrobials in dermatology: An overview

Bubna, A. K. (2023) · Indian Journal of Drugs in Dermatology · doi:10.4103/ijdd.ijdd_33_23

Newer Antimicrobials

Bubna, A. K. (2025) · Springer eBooks · doi:10.1007/978-981-95-3791-4_10

Lokalisation und Typisierung multiresistenter Staphylokokken bei Hunden mit Pyodermie und ihren Besitzern

Horstmann, C. (2012) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.15268

Tetracyclines, a timely resurgence or doomed to fail again?

Fenn, S. J., Panagiotopoulou, D., & Hardie, K. R. (2026) · Journal of Medical Microbiology · doi:10.1099/jmm.0.002197

Inhibition of protein synthesis occurring on tetracycline-resistant, TetM-protected ribosomes by a novel class of tetracyclines, the glycylcyclines

Rasmussen, B. A., Gluzman, Y., & Tally, F. P. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.7.1658 · Cited by 62

Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA

Bauer, G. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh125 · Cited by 163

Structural Characterization of an Alternative Mode of Tigecycline Binding to the Bacterial Ribosome

Schedlbauer, A., Kaminishi, T., Ochoa-Lizarralde, B., Dhimole, N., Zhou, S., López-Alonso, J. P., Connell, S. R., & Fucini, P. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04895-14 · Cited by 49

Binding of Tetracyclines to Elongation Factor Tu, the Tet Repressor, and the Ribosome: A Molecular Dynamics Simulation Study

Aleksandrov, A. V., & Simonson, T. (2008) · Biochemistry · doi:10.1021/bi801726q · Cited by 24

Molecular Docking Analysis of Tetracycline and Tigecycline Binding to the 30S Ribosomal Subunit: Structural Insights into Antibiotic Action and Resistance Mechanisms

Raphael, O. O. (2025) · doi:10.13140/rg.2.2.34926.68161