Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica
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The ability of Entamoeba histolytica trophozoites to destroy monolayers of baby hamster kidney cells is inhibited by allicin, one of the active principles of garlic. Cysteine proteinases, an important contributor to amebic virulence, as well as alcohol dehydrogenase, are strongly inhibited by allicin.
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The current results and previous findings support the potential utilization of Allium spp. (wild and traditional type) extracts against fungi and other microbial pathogens.
“The current results and the previous findings of other scientist support the potential utilization of Allium spp. (wild and traditional type) extracts against fungi and other microbial pathogens22–24.”
From Bioactivities of Allium longicuspis Regel against anthracnose of mango caused by Colletotrichum gloeosporioides (Penz.) (2020) · cites this paper as [22]
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- Authors
- Ankri, S., Miron, T., Rabinkov, A., Wilchek, M., & Mirelman, D.
- Affiliations
- Weizmann Institute of Science (IL)
- ORCID
- Ankri, S
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1997-10
- Volume
- 41
- Issue
- 10
- Pages
- 2286-2288
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC164109
- OpenAlex
- W2154918465
- Cited by
- 176
- References
- 20
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 14 · 2014: 6 · 2013: 13 · 2012: 9
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Infectious Diseases › Amoebic Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- allicin, garlic, Entamoeba histolytica, cysteine protease, cytopathic effect, alcohol dehydrogenase inhibition, trophozoites, BHK cells, amoebiasis
- MeSH terms
- Alcohol Dehydrogenase, Animals, Anti-Infective Agents, Cell Survival, Cells, Cultured, Disulfides, Entamoeba histolytica, Entamoebiasis, Garlic, Cricetinae, Kinetics, Microbial Sensitivity Tests, Plants, Medicinal, Sulfinic Acids, Cysteine Proteinase Inhibitors
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