Cited by 178Garlic and Onion StudiesAmoebic Infections and TreatmentsEssential Oils and Antimicrobial Activity

Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica

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Ankri, S, Miron, T, Rabinkov, A, Wilchek, M, Mirelman, D·1997·Antimicrobial Agents and Chemotherapy

Abstract

The ability of Entamoeba histolytica trophozoites to destroy monolayers of baby hamster kidney cells is inhibited by allicin, one of the active principles of garlic. Cysteine proteinases, an important contributor to amebic virulence, as well as alcohol dehydrogenase, are strongly inhibited by allicin.

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Crossref · 10.1128/aac.41.10.2286

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20 of 20 references verified0 citation errors · 0 not checkable

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Authors
Ankri, S., Miron, T., Rabinkov, A., Wilchek, M., & Mirelman, D.
Affiliations
Weizmann Institute of Science (IL)
Venue
Antimicrobial Agents and Chemotherapy
Published
1997-10
Volume
41
Issue
10
Pages
2286-2288
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2154918465
Cited by
176
References
20
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 14 · 2014: 6 · 2013: 13 · 2012: 9
FWCI
4.33
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Health Sciences › Medicine › Infectious Diseases › Amoebic Infections and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
Keywords
allicin, garlic, Entamoeba histolytica, cysteine protease, cytopathic effect, alcohol dehydrogenase inhibition, trophozoites, BHK cells, amoebiasis
MeSH terms
Alcohol Dehydrogenase, Animals, Anti-Infective Agents, Cell Survival, Cells, Cultured, Disulfides, Entamoeba histolytica, Entamoebiasis, Garlic, Cricetinae, Kinetics, Microbial Sensitivity Tests, Plants, Medicinal, Sulfinic Acids, Cysteine Proteinase Inhibitors

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