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Impact of Bacterial Biofilm Formation on In Vitro and In Vivo Activities of Antibiotics
Open accessAbstract
The impact of bacterial adherence on antibiotic activity was analyzed with two isogenic strains of Staphylococcus epidermidis that differ in the features of their in vitro biofilm formation. The eradication of bacteria adhering to glass beads by amikacin, levofloxacin, rifampin, or teicoplanin was studied in an animal model and in a pharmacokinetically matched in vitro model. The features of S. epidermidis RP62A that allowed it to grow on surfaces in multiple layers promoted phenotypic resistance to antibiotic treatment, whereas strain M7 failed to accumulate, despite initial adherence on surfaces and growth in suspension similar to those for RP62A. Biofilms of S. epidermidis M7 were better eradicated than those of strain RP62A in vitro (46 versus 31%; P < 0.05) as well as in the animal model (39 versus 9%; P < 0.01).
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Cited by
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Self-citationAl-Fattani, M. A., & Douglas, L. J. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46569-0 · Cited by 548
Clinical presentation and treatment of orthopaedic implant‐associated infection
Zimmerli, W. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12233 · Cited by 481
Self-citationRachid, S., Ohlsen, K., Witte, W., Hacker, J., & Ziebuhr, W. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.12.3357-3363.2000 · Cited by 373
Metadata
- Authors
- Schwank, S., Rajacic, Z., Zimmerli, W., & Blaser, J.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1998-04
- Volume
- 42
- Issue
- 4
- Pages
- 895-898
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2164974110
- Cited by
- 167
- References
- 0
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schwank, S., Rajacic, Z., Zimmerli, W., & Blaser, J. (1998). Impact of Bacterial Biofilm Formation on In Vitro and In Vivo Activities of Antibiotics. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.42.4.895
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
