The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan
Open accessAbstract
Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type inhA gene on a multicopy plasmid. Replacement of the mutant chromosomal inhA genes with wild-type inhA eliminated resistance. These results suggest that M. smegmatis InhA, like its Escherichia coli homolog FabI, is a target for triclosan.
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Citations
Cites
inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis
Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K. S., Wilson, T., Collins, D., de Lisle, G., & Jacobs, W. R. (1994) · Science · doi:10.1126/science.8284673 · Cited by 1,389
Cited by
The impact of antibiotic use on resistance development and persistence
Barbosa, T. M., & Levy, S. B. (2000) · Drug Resistance Updates · doi:10.1054/drup.2000.0167 · Cited by 493
Self-citationBacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery
Campbell, J. W., & Cronan, J. E. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.305 · Cited by 479
Triclosan: a widely used biocide and its link to antibiotics
Schweizer, H. (2001) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(01)00273-7 · Cited by 447
Bacterial target sites for biocide action: ANTIBACTERIAL MECHANISMS OF ACTION OF BIOCIDES
Maillard, J.-Y. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.92.5s1.3.x · Cited by 422
Russell, A. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00833-8 · Cited by 419
Metadata
- Authors
- McMurry, L. M., McDermott, P. F., & Levy, S. B.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1999-03
- Volume
- 43
- Issue
- 3
- Pages
- 711-713
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2171243523
- Cited by
- 214
- References
- 1
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- green
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- McMurry, L. M., McDermott, P. F., & Levy, S. B. (1999). Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.43.3.711
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
