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Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ
Open accessAbstract
Triclosan is an antiseptic frequently added to items as diverse as soaps, lotions, toothpaste, and many commonly used household fabrics and plastics. Although wild-type Pseudomonas aeruginosa expresses the triclosan target enoyl-acyl carrier protein reductase, it is triclosan resistant due to expression of the MexAB-OprM efflux system. Exposure of a susceptible Δ( mexAB-oprM ) strain to triclosan selected multidrug-resistant bacteria at high frequencies. These bacteria hyperexpressed the MexCD-OprJ efflux system due to mutations in its regulatory gene, nfxB . The MICs of several drugs for these mutants were increased up to 500-fold, including the MIC of ciprofloxacin, which was increased 94-fold. Whereas the MexEF-OprN efflux system also participated in triclosan efflux, this antimicrobial was not a substrate for MexXY-OprM.
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Citations
Cited by
Antibiotics in the aquatic environment – A review – Part I
Kümmerer, K. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2008.11.086 · Cited by 4,475
Guideline for hand hygiene in health-care settings
Boyce, J. M., & Pittet, D. (2002) · American Journal of Infection Control · doi:10.1067/mic.2002.130391 · Cited by 2,120
Antibiotics in the aquatic environment – A review – Part II
Kümmerer, K. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2008.12.006 · Cited by 1,298
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
BacMet: antibacterial biocide and metal resistance genes database
Pal, C., Bengtsson-Palme, J., Rensing, C., Kristiansson, E., & Larsson, D. G. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1252 · Cited by 955
Metadata
- Authors
- Chuanchuen, R., Beinlich, K., Hoang, T. T., Becher, A., Karkhoff-Schweizer, R. R., & Schweizer, H. P.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2001-02
- Volume
- 45
- Issue
- 2
- Pages
- 428-432
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2025175179
- Cited by
- 426
- References
- 0
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ. https://app.cochat.ai/papers/10.1128/aac.45.2.428-432.2001
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- Chuanchuen, R., Beinlich, K., Hoang, T. T., Becher, A., Karkhoff-Schweizer, R. R., & Schweizer, H. P. (2001). Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.45.2.428-432.2001
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