Efflux-mediated antimicrobial resistance

Poole, Keith

doi:10.1093/jac/dki171

Cited by 1,082Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

Efflux-mediated antimicrobial resistance

Poole, Keith·2005·Journal of Antimicrobial Chemotherapy

DOI 10.1093/jac/dki171

Open this paper in CoChat — free account

Abstract

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease. And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of reduced biocide susceptibility are common and the history of antibiotic resistance should not be ignored in the development and use of biocidal agents. Efflux mechanisms of resistance, both drug specific and multidrug, are important determinants of intrinsic and/or acquired resistance to these antimicrobials, with some accommodating both antibiotics and biocides. This latter raises the spectre (as yet generally unrealized) of biocide selection of multiple antibiotic-resistant organisms. Multidrug efflux mechanisms are broadly conserved in bacteria, are almost invariably chromosome-encoded and their expression in many instances results from mutations in regulatory genes. In contrast, drug-specific efflux mechanisms are generally encoded by plasmids and/or other mobile genetic elements (transposons, integrons) that carry additional resistance genes, and so their ready acquisition is compounded by their association with multidrug resistance. While there is some support for the latter efflux systems arising from efflux determinants of self-protection in antibiotic-producing Streptomyces spp. and, thus, intended as drug exporters, increasingly, chromosomal multidrug efflux determinants, at least in Gram-negative bacteria, appear not to be intended as drug exporters but as exporters with, perhaps, a variety of other roles in bacterial cells. Still, given the clinical significance of multidrug (and drug-specific) exporters, efflux must be considered in formulating strategies/approaches to treating drug-resistant infections, both in the development of new agents, for example, less impacted by efflux and in targeting efflux directly with efflux inhibitors.

Integrity signals

Registry

Crossref · 10.1093/jac/dki171

Cites

733 of 733 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Many Tet pumps affect tetracycline and doxycycline but do not decrease minocycline or tigecycline susceptibility, because they cannot use these compounds as substrates.
“Importantly, many of these pumps affect tetracycline and doxycycline, but do not decrease minocycline or tigecycline susceptibility, as they are not able to use these compounds as substrates (44, 47).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [44]
Lsa is a predicted efflux pump encoded by the chromosomal gene lsa that is responsible for intrinsic resistance of E. faecalis to lincosamides and streptogramin A, the LSA phenotype.
“Finally, another predicted efflux pump is Lsa (encoded by the chromosomal gene lsa), which is responsible for the intrinsic resistance of E. faecalis to lincosamides and streptogramin A (LSA phenotype) (44, 45).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [44]
Efflux systems may be substrate-specific or have broad substrate specificity, and broad-specificity systems are usually found in MDR bacteria.
“These systems may be substrate-specific (for a particular antibiotic such as tet determinants for tetracycline and mef genes for macrolides in pneumococci) or with broad substrate specificity, which are usually found in MDR bacteria (44).”
From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [44]

1 retracted

RETRACTED: Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli
Ma, C., & Chang, G. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400137101 · Cited by 102 · see citing works
Retracted
Antiseptics and Disinfectants: Activity, Action, and Resistance
McDonnell, G. E., & Russell, A. D. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.147 · Cited by 4,795 · see citing works
Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
Chopra, I., & Roberts, M. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.2.232-260.2001 · Cited by 4,517 · see citing works
Antibacterial resistance worldwide: causes, challenges and responses
Levy, S. B., & Marshall, B. M. (2004) · Nature Medicine · doi:10.1038/nm1145 · Cited by 4,047 · see citing works
Understanding biofilm resistance to antibacterial agents
Davies, D. G. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1008 · Cited by 2,791 · see citing works
Survival strategies of infectious biofilms
Fux, C. A., Costerton, J. W., Stewart, P. S., & Stoodley, P. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.11.010 · Cited by 1,812 · see citing works
Colistin: The Revival of Polymyxins for the Management of Multidrug-Resistant Gram-Negative Bacterial Infections
Falagas, M. E., Kasiakou, S. K., & Saravolatz, L. D. (2005) · Clinical Infectious Diseases · doi:10.1086/429323 · Cited by 1,745 · see citing works
Sampling the Antibiotic Resistome
D'Costa, V. M., McGrann, K. M., Hughes, D. W., & Wright, G. D. (2006) · Science · doi:10.1126/science.1120800 · Cited by 1,594 · see citing works
Efflux-mediated heavy metal resistance in prokaryotes
Nies, D. H. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00048-2 · Cited by 1,567 · see citing works
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,523 · see citing works
An Enzyme from Bacteria able to Destroy Penicillin
Abraham, E. P., & Chain, E. B. (1940) · Nature · doi:10.1038/146837a0 · Cited by 1,335 · see citing works
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
Smith, E. E., Buckley, D. G., Wu, Z., Saenphimmachak, C., Hoffman, L. R., D’Argenio, D. A., Miller, S. I., Ramsey, B. W., Speert, D. P., Moskowitz, S. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602138103 · Cited by 1,319 · see citing works
Bacterial silver resistance: molecular biology and uses and misuses of silver compounds
Silver, S. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00047-0 · Cited by 1,312 · see citing works
A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance
Mah, T., Pitts, B., Pellock, B. J., Walker, G. C., Stewart, P. S., & O’Toole, G. A. (2003) · Nature · doi:10.1038/nature02122 · Cited by 1,190 · see citing works
Mechanisms of Resistance to Macrolides and Lincosamides: Nature of the Resistance Elements and Their Clinical Implications
Leclercq, R. (2002) · Clinical Infectious Diseases · doi:10.1086/324626 · Cited by 1,102 · see citing works
Proton-dependent multidrug efflux systems
Paulsen, I. T., Brown, M. H., & Skurray, R. A. (1996) · Microbiological Reviews · doi:10.1128/mr.60.4.575-608.1996 · Cited by 1,089 · see citing works
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
Koronakis, V. E., Sharff, A., Koronakis, E., Luisi, B. F., & Hughes, C. (2000) · Nature · doi:10.1038/35016007 · Cited by 1,086 · see citing works
Update on acquired tetracycline resistance genes
Roberts, M. C. (2005) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2005.02.034 · Cited by 1,010 · see citing works
Adverse Clinical and Economic Outcomes Attributable to Methicillin Resistance among Patients with Staphylococcus aureus Surgical Site Infection
Engemann, J. J., Carmeli, Y., Cosgrove, S. E., Fowler, V. G., Bronstein, M. Z., Trivette, S. L., Briggs, J. P., Sexton, D. J., & Kaye, K. S. (2003) · Clinical Infectious Diseases · doi:10.1086/367653 · Cited by 934 · see citing works
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy
Lomovskaya, O., Warren, M. S., Lee, A. Y., Galazzo, J. L., Fronko, R. M., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., et al. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.105-116.2001 · Cited by 903 · see citing works
Nomenclature for Macrolide and Macrolide-Lincosamide-Streptogramin B Resistance Determinants
Roberts, M. C., Sutcliffe, J. A., Courvalin, P. M., Jensen, L. B., Rood, J. I., & Seppälä, H. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2823 · Cited by 874 · see citing works
Multiplex PCR for the detection of tetracycline resistant genes
Ng, L. ‐., Martín, I., Alfa, M. J., & Mulvey, M. R. (2001) · Molecular and Cellular Probes · doi:10.1006/mcpr.2001.0363 · Cited by 872 · see citing works
Efflux-Mediated Drug Resistance in Bacteria
Li, X.-Z., & Nikaido, H. (2004) · Drugs · doi:10.2165/00003495-200464020-00004 · Cited by 803 · see citing works
Molecular basis of bacterial resistance to chloramphenicol and florfenicol
Schwarz, Š., Kehrenberg, C., Doublet, B., & Cloeckaert, A. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.04.001 · Cited by 803 · see citing works
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 792 · see citing works
Mechanisms of Solvent Tolerance in Gram-Negative Bacteria
Ramos, J. L., Duque, E., Gallegos, M., Godoy, P., Ramos‐González, M. I., Rojas, A., Terán, W., & Segura, A. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.161038 · Cited by 792 · see citing works
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Murakami, S., Nakashima, R., Yamashita, E., Matsumoto, T., & Yamaguchi, A. (2006) · Nature · doi:10.1038/nature05076 · Cited by 772 · see citing works
Epidemiologic Background of Hand Hygiene and Evaluation of the Most Important Agents for Scrubs and Rubs
Kampf, G., & Krämer, A. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.863-893.2004 · Cited by 760 · see citing works
Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa
Masuda, N., Sakagawa, E., Ohya, S., Gotoh, N., Tsujimoto, H., & Nishino, T. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.12.3322-3327.2000 · Cited by 720 · see citing works
Tetracycline resistance determinants: Mechanisms of action, regulation of expression, genetic mobility, and distribution
Roberts, M. C. (1996) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1996.tb00251.x · Cited by 689 · see citing works
Analysis of a Complete Library of Putative Drug Transporter Genes in Escherichia coli
Nishino, K., & Yamaguchi, A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.20.5803-5812.2001 · Cited by 667 · see citing works
The Impact of Antimicrobial Resistance on Health and Economic Outcomes
Eliopoulos, G. M., Cosgrove, S. E., & Carmeli, Y. (2003) · Clinical Infectious Diseases · doi:10.1086/375081 · Cited by 637 · see citing works
Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis
Harbarth, S., Garbino, J., Pugin, J., Romand, J. A., Lew, D., & Pittet, D. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.07.005 · Cited by 635 · see citing works
Efflux-mediated multiresistance in Gram-negative bacteria
Poole, K. (2004) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2004.00763.x · Cited by 612 · see citing works
Self-citation
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
McMurry, L. M., Petrucci, R., & Levy, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3974 · Cited by 606 · see citing works
Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia.
Lodise, T. P., McKinnon, P. S., Swiderski, L., & Rybak, M. J. (2003) · Clinical Infectious Diseases · doi:10.1086/375057 · Cited by 604 · see citing works
Genes acrA and acrB encode a stress‐induced efflux system of Escherichia coli
Ma, D., Cook, D. N., Alberti, M., Pon, N. G., Nikaido, H., & Hearst, J. E. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02390.x · Cited by 602 · see citing works
Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism
Seeger, M. A., Schiefner, A., Eicher, T., Verrey, F., Diederichs, K., & Pos, K. M. (2006) · Science · doi:10.1126/science.1131542 · Cited by 590 · see citing works
Multiplex PCR Assay for Simultaneous Detection of Nine Clinically Relevant Antibiotic Resistance Genes in Staphylococcus aureus
Strommenger, B., Kettlitz, C., Werner, G., & Witte, W. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.9.4089-4094.2003 · Cited by 579 · see citing works
Distribution of Genes Encoding Resistance to Macrolides, Lincosamides, and Streptogramins among Staphylococci
Lina, G., Quaglia, A., Reverdy, M. E., Leclercq, R., Vandenesch, F., & Étienne, J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1062 · Cited by 547 · see citing works
Bacterial efflux pump inhibitors from natural sources
Stavri, M., Piddock, L. J. V., & Gibbons, S. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl460 · Cited by 547 · see citing works
CmeABC Functions as a Multidrug Efflux System in Campylobacter jejuni
Lin, J., Michel, L. O., & Zhang, Q. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.7.2124-2131.2002 · Cited by 529 · see citing works
Antimicrobial resistance of Pseudomonas aeruginosa biofilms
Drenkard, E. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.08.009 · Cited by 520 · see citing works
Multidrug Pump Inhibitors Uncover Remarkable Activity of Plant Antimicrobials
Tegos, G. P., Stermitz, F. R., Lomovskaya, O., & Lewis, K. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.10.3133-3141.2002 · Cited by 518 · see citing works
Mechanisms of bacterial biocide and antibiotic resistance
Poole, K. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.92.5s1.8.x · Cited by 508 · see citing works
Self-citation
Oxygen Limitation Contributes to Antibiotic Tolerance of Pseudomonas aeruginosa in Biofilms
Borriello, G., Werner, E., Roe, F., Kim, A. M., Ehrlich, G. D., & Stewart, P. S. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2659-2664.2004 · Cited by 480 · see citing works
Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones
Yoshida, H., Bogaki, M., Nakamura, S., Ubukata, K., & Konno, M. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.12.6942-6949.1990 · Cited by 479 · see citing works
Molecular basis for resistance to silver cations in Salmonella
Gupta, A. K., Matsui, K., Lo, J., & Silver, S. D. (1999) · Nature Medicine · doi:10.1038/5545 · Cited by 474 · see citing works
Active efflux of bile salts by Escherichia coli
Thanassi, D. G., Cheng, L. W., & Nikaido, H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.8.2512-2518.1997 · Cited by 471 · see citing works
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein
Rosenberg, E. Y., Bertenthal, D., Nilles, M. L., Bertrand, K. P., & Nikaido, H. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03531.x · Cited by 469 · see citing works
Aminoglycoside Resistance in Pseudomonas aeruginosa
Poole, K. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.479-487.2005 · Cited by 469 · see citing works
Self-citation
Mechanisms of Resistance in Multiple-Antibiotic-Resistant Escherichia coli Strains of Human, Animal, and Food Origins
Sáenz, Y., Briñas, L., Domínguez, E., Ruiz, J., Zarazaga, M., Vilà, J., & Torres, C. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3996-4001.2004 · Cited by 464 · see citing works
Outcome and Attributable Mortality in Critically Ill Patients With Bacteremia Involving Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus
Blot, S. I., Vandewoude, K., Hoste, E. A. J., & COLARDYN, F. A. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.19.2229 · Cited by 462 · see citing works
Practical applications and feasibility of efflux pump inhibitors in the clinic—A vision for applied use
Lomovskaya, O., & Bostian, K. A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.008 · Cited by 461 · see citing works
Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms.
Poole, K. (2001) · PubMed · Cited by 450 · see citing works
Self-citation
Proton-dependent multidrug efflux systems.
Paulsen, I. T., Brown, M. H., & Skurray, R. A. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.4.575-608.1996 · Cited by 448 · see citing works
Evolution and spread of antibiotic resistance
Normark, B. H., & Normark, S. J. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01026.x · Cited by 441 · see citing works
Triclosan: a widely used biocide and its link to antibiotics
Schweizer, H. P. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10772.x · Cited by 434 · see citing works
Cross-Resistance between Triclosan and Antibiotics in Pseudomonas aeruginosa Is Mediated by Multidrug Efflux Pumps: Exposure of a Susceptible Mutant Strain to Triclosan Selects nfxB Mutants Overexpressing MexCD-OprJ
Chuanchuen, R., Beinlich, K., Hoang, T. T., Becher, A., Karkhoff-Schweizer, R. R., & Schweizer, H. P. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.2.428-432.2001 · Cited by 427 · see citing works
Regulation of bacterial drug export systems
Grkovic, S., Brown, M. H., & Skurray, R. A. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.671-701.2002 · Cited by 423 · see citing works
Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus
Kaatz, G. W., Seo, S. M., & Ruble, C. A. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.5.1086 · Cited by 415 · see citing works
Antibiotic resistance genes, integrons and multiple antibiotic resistance in thirty-five serotypes of Salmonella enterica isolated from humans and animals in the UK
Randall, L. P. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh070 · Cited by 410 · see citing works
Interplay of Efflux System, ampC , and oprD Expression in Carbapenem Resistance of Pseudomonas aeruginosa Clinical Isolates
Quale, J. M., Bratu, S., Gupta, J., & Landman, D. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1633-1641.2006 · Cited by 409 · see citing works
Expression of the RND-Type Efflux Pump AdeABC in Acinetobacter baumannii Is Regulated by the AdeRS Two-Component System
Marchand, I., Damier-Piolle, L., Courvalin, P. M., & Lambert, T. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3298-3304.2004 · Cited by 406 · see citing works
Active efflux, a common mechanism for biocide and antibiotic resistance
Levy, S. B. (2002) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.92.5s1.4.x · Cited by 405 · see citing works
Comparative Genome Sequencing for Discovery of Novel Polymorphisms in Bacillus anthracis
Read, T. D., Salzberg, S. L., Pop, M., Shumway, M. F., Umayam, L. A., Jiang, L., Holtzapple, E., Busch, J. D., Smith, K. L., Schupp, J. M., et al. (2002) · Science · doi:10.1126/science.1071837 · Cited by 403 · see citing works
The mar regulon: multiple resistance to antibiotics and other toxic chemicals
Alekshun, M. N., & Levy, S. B. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01589-9 · Cited by 399 · see citing works
Of Pseudomonas, porins, pumps and carbapenems
Livermore, D. M. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/47.3.247 · Cited by 393 · see citing works
NorM, a Putative Multidrug Efflux Protein, of Vibrio parahaemolyticus and Its Homolog in Escherichia coli
Morita, Y., Kodama, K., Shiota, S., Mine, T., Kataoka, A., Mizushima, T., & Tsuchiya, T. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.7.1778 · Cited by 391 · see citing works
MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition
Edgar, R., & Bibi, E. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.7.2274-2280.1997 · Cited by 385 · see citing works
Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium
Nishino, K., Latifi, T. N., & Groisman, E. A. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04940.x · Cited by 385 · see citing works
Efflux-Mediated Resistance to Fluoroquinolones in Gram-Negative Bacteria
Poole, K. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2233-2241.2000 · Cited by 372 · see citing works
Self-citation
The physiology and collective recalcitrance of microbial biofilm communities
Gilbert, P., Maira‐Litrán, T., McBain, A. J., Rickard, A. H., & Fw, W. (2002) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(02)46005-5 · Cited by 371 · see citing works
Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system
Hagman, K. E., Spratt, B. G., Balthazar, J. T., Pan, W., Judd, R. C., & Shafer, W. M. (1995) · Microbiology · doi:10.1099/13500872-141-3-611 · Cited by 368 · see citing works
Antibacterial and resistance modifying activity of
Oluwatuyi, M., Kaatz, G. W., & Gibbons, S. (2004) · Phytochemistry · doi:10.1016/j.phytochem.2004.10.009 · Cited by 363 · see citing works
Triclosan and Antimicrobial Resistance in Bacteria: An Overview
Yazdankhah, S. P., Scheie, A. A., H⊘iby, E. A., Lunestad, B.-T., Heir, E., Fotland, T. Ø., Naterstad, K., & Kruse, H. (2006) · Microbial Drug Resistance · doi:10.1089/mdr.2006.12.83 · Cited by 362 · see citing works
Phenotypic and genotypic characterization of antimicrobial resistance in German Escherichia coli isolates from cattle, swine and poultry.
Guerra, B., Junker, E., Schroeter, A., Malorny, B., Lehmann, S., & Helmuth, R. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg362 · Cited by 361 · see citing works
Resistance to ?-lactam antibiotics
Poole, K. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4060-9 · Cited by 359 · see citing works
Self-citation
Novel Macrolide-Specific ABC-Type Efflux Transporter in Escherichia coli
Kobayashi, N., Nishino, K., & Yamaguchi, A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.19.5639-5644.2001 · Cited by 356 · see citing works
Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43
Chen, Y.-T., Chang, H.-Y., Lai, Y.-C., Pan, C.-C., Tsai, S.-F., & Peng, H.-L. (2004) · Gene · doi:10.1016/j.gene.2004.05.008 · Cited by 351 · see citing works
A review of the microbiology, antibiotic usage and resistance in chronic skin wounds
Howell‐Jones, R., Wilson, M. J., Hill, K. E., Howard, A., Price, P., & Thomas, D. W. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh513 · Cited by 348 · see citing works
Overexpression ofmarA, soxS, oracrABproduces resistance to triclosan in laboratory and clinical strains ofEscherichia coli
McMurry, L. M., Oethinger, M. D., & Levy, S. B. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13905.x · Cited by 346 · see citing works
EmrE, an Escherichia coli 12-kDa Multidrug Transporter, Exchanges Toxic Cations and H+ and Is Soluble in Organic Solvents
Yerushalmi, H. F., Lebendiker, M., & Schuldiner, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.12.6856 · Cited by 337 · see citing works
Potential Impact of Increased Use of Biocides in Consumer Products on Prevalence of Antibiotic Resistance
Gilbert, P., & McBain, A. J. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.2.189-208.2003 · Cited by 335 · see citing works
Role of mycobacterial efflux transporters in drug resistance: an unresolved question
Rossi, E. D., Aínsa, J. A., & Riccardi, G. (2005) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2005.00002.x · Cited by 324 · see citing works
The 3' conserved segment of integrons contains a gene associated with multidrug resistance to antiseptics and disinfectants
Paulsen, I. T., Littlejohn, T. G., Rådström, P., Sundström, L., Sköld, O., Swedberg, G., & Skurray, R. A. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.4.761 · Cited by 320 · see citing works
Evolution of Two-Component Signal Transduction
Koretke, K. K., Lupas, A. N., Warren, P. V., Rosenberg, M. J., & Brown, J. R. (2000) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026297 · Cited by 315 · see citing works
Critical Role of Multidrug Efflux Pump CmeABC in Bile Resistance and In Vivo Colonization ofCampylobacter jejuni
Lin, J., Şahin, O., Michel, L. O., & Zhang, Q. (2003) · Infection and Immunity · doi:10.1128/iai.71.8.4250-4259.2003 · Cited by 308 · see citing works
The Glycylcyclines
Zhanel, G. G., Homenuik, K., Nichol, K. A., Noreddin, A. M., Vercaigne, L. M., Embil, J. M., Gin, A. S., Karlowsky, J. A., & Hoban, D. J. (2004) · Drugs · doi:10.2165/00003495-200464010-00005 · Cited by 305 · see citing works
Efflux-Mediated Aminoglycoside and Macrolide Resistance in Burkholderia pseudomallei
Moore, R. A., DeShazer, D., Reckseidler-Zenteno, S., Weissman, A., & Woods, D. E. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.3.465 · Cited by 304 · see citing works
Quinolone generations: natural history or natural selection?
Ball, P. D. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/oxfordjournals.jac.a020889 · Cited by 303 · see citing works
Characterization of MexT, the Regulator of the MexE-MexF-OprN Multidrug Efflux System of Pseudomonas aeruginosa
Köhler, T., Epp, S. F., Curty, L. K., & Pechère, J.-C. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.20.6300-6305.1999 · Cited by 302 · see citing works
Review of Macrolides and Ketolides
Zhanel, G. G., Dueck, M., Hoban, D. J., Vercaigne, L. M., Embil, J. M., Gin, A. S., & Karlowsky, J. A. (2001) · Drugs · doi:10.2165/00003495-200161040-00003 · Cited by 300 · see citing works
ABC-transporters: implications on drug resistance from microorganisms to human cancers
Lage, H. (2003) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(03)00203-6 · Cited by 299 · see citing works
MgrA Is a Multiple Regulator of Two New Efflux Pumps in Staphylococcus aureus
Truong, Q. C., Dunman, P. M., Strahilevitz, J., Projan, S. J., & Hooper, D. C. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.7.2395-2405.2005 · Cited by 296 · see citing works
Tetracycline Therapy: Update
Roberts, M. C. (2003) · Clinical Infectious Diseases · doi:10.1086/367622 · Cited by 295 · see citing works
Incidence and Characterization of Integrons, Genetic Elements Mediating Multiple-Drug Resistance, in Avian Escherichia coli
Bass, L., Liebert, C. A., Lee, M. D., Summers, A. O., White, D. G., Thayer, S. G., & Maurer, J. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2925 · Cited by 291 · see citing works
The BaeSR Two-Component Regulatory System Activates Transcription of the yegMNOB ( mdtABCD ) Transporter Gene Cluster in Escherichia coli and Increases Its Resistance to Novobiocin and Deoxycholate
Baranova, N. N., & Nikaido, H. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.15.4168-4176.2002 · Cited by 290 · see citing works
The Putative Response Regulator BaeR Stimulates Multidrug Resistance of Escherichia coli via a Novel Multidrug Exporter System, MdtABC
Nagakubo, S., Nishino, K., Hirata, T., & Yamaguchi, A. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.15.4161-4167.2002 · Cited by 288 · see citing works
Overexpression of the MexEF-OprN Multidrug Efflux System Affects Cell-to-Cell Signaling in Pseudomonas aeruginosa
Köhler, T., van Delden, C., Curty, L. K., Michea-Hamzehpour, M., & Péchère, J.-C. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5213-5222.2001 · Cited by 287 · see citing works
Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
Dean, C. R., Visalli, M. A., Projan, S. J., Sum, P.-E., & Bradford, P. A. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.3.972-978.2003 · Cited by 286 · see citing works
Genetic Characterization of Highly Fluoroquinolone-Resistant Clinical Escherichia coli Strains from China: Role of acrR Mutations
Wang, H., Dzink-Fox, J., Chen, M., & Levy, S. B. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.5.1515-1521.2001 · Cited by 284 · see citing works
Multidrug Efflux in Pseudomonas aeruginosa Components, Mechanisms and Clinical Significance
Poole, K., & Srikumar, R. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013395605 · Cited by 279 · see citing works
Self-citation
Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa
Masuda, N., Sakagawa, E., Ohya, S., Gotoh, N., Tsujimoto, H., & Nishino, T. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2242-2246.2000 · Cited by 279 · see citing works
Multidrug Resistance in Staphylococcus aureus Due to Overexpression of a Novel Multidrug and Toxin Extrusion (MATE) Transport Protein
Kaatz, G. W., McAleese, F., & Seo, S. M. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1857-1864.2005 · Cited by 279 · see citing works
Structure and function of efflux pumps that confer resistance to drugs
Borges-Walmsley, M. I., McKeegan, K. S., & Walmsley, A. R. (2003) · Biochemical Journal · doi:10.1042/bj20020957 · Cited by 278 · see citing works
Clinical Strains of Pseudomonas aeruginosa Overproducing MexAB-OprM and MexXY Efflux Pumps Simultaneously
Llanes, C., Hocquet, D., Vogne, C., Benali-Baitich, D., Neuwirth, C., & Plésiat, P. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1797-1802.2004 · Cited by 278 · see citing works
Multidrug resistance in Gram-negative bacteria
Poole, K. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00242-3 · Cited by 277 · see citing works
Self-citation
AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex
Tikhonova, E. B., & Zgurskaya, H. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402230200 · Cited by 276 · see citing works
Adaptive Resistance to Biocides in Salmonella enterica and Escherichia coli O157 and Cross-Resistance to Antimicrobial Agents
Braoudaki, M., & Hilton, A. C. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.1.73-78.2004 · Cited by 273 · see citing works
Inducible NorA-mediated multidrug resistance in Staphylococcus aureus
Kaatz, G. W., & Seo, S. M. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.12.2650 · Cited by 268 · see citing works
Pseudomonas aeruginosaVirulence Analyzed in aDictyostelium discoideumHost System
Cosson, P., Zulianello, L., Join‐Lambert, O., Faurisson, F., Gebbie, L. K., Benghezal, M., van Delden, C., Curty, L. K., & Köhler, T. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.11.3027-3033.2002 · Cited by 268 · see citing works
An Enterococcus faecalis ABC Homologue (Lsa) Is Required for the Resistance of This Species to Clindamycin and Quinupristin-Dalfopristin
Singh, K. V., Weinstock, G. M., & Murray, B. E. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1845-1850.2002 · Cited by 263 · see citing works
AcrD of Escherichia coli Is an Aminoglycoside Efflux Pump
Rosenberg, E. Y., Ma, D., & Nikaido, H. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.6.1754-1756.2000 · Cited by 259 · see citing works
Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae
Gill, M. J., Brenwald, N. P., & Wise, R. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.1.187 · Cited by 259 · see citing works
Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas aeruginosa
Hirakata, Y., Srikumar, R., Poole, K., Gotoh, N., Suematsu, T., Kohno, S., Kamihira, S., Hancock, R. E. W., & Speert, D. P. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020005 · Cited by 256 · see citing works
Self-citation
Crystal Structure of the Membrane Fusion Protein, MexA, of the Multidrug Transporter in Pseudomonas aeruginosa
Akama, H., Matsuura, T., Kashiwagi, S., Hiroshi Yoneyama, C., Narita, S., Tomitake Tsukihara, A., Nakagawa, A., & Nakae, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400164200 · Cited by 255 · see citing works
Structure of the periplasmic component of a bacterial drug efflux pump
Higgins, M. K., Bokma, E., Koronakis, E., Hughes, C., & Koronakis, V. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400375101 · Cited by 254 · see citing works
In Vivo Selection of Campylobacter Isolates with High Levels of Fluoroquinolone Resistance Associated with gyrA Mutations and the Function of the CmeABC Efflux Pump
Luo, N., Şahin, O., Lin, J., Michel, L. O., & Zhang, Q. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.1.390-394.2003 · Cited by 251 · see citing works
Occurrence of HypermutablePseudomonas aeruginosain Cystic Fibrosis Patients Is Associated with the Oxidative Stress Caused by Chronic Lung Inflammation
Ciofu, O., Riis, B. J., Pressler, T., Poulsen, H. E., & Høiby, N. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.6.2276-2282.2005 · Cited by 250 · see citing works
Cationic Antimicrobial Peptide Resistance in Neisseria meningitidis
Tzeng, Y., Ambrose, K. D., Zughaier, S. M., Zhou, X., Miller, Y. K., Shafer, W. M., & Stephens, D. S. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.15.5387-5396.2005 · Cited by 248 · see citing works
Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report
Peleg, A. Y., Potoski, B. A., Rea, R. S., Adams, J. M., Sethi, J., Capitano, B., Husain, S., Kwak, E. J., Bhat, S. V., & Paterson, D. L. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl441 · Cited by 248 · see citing works
Characterization of a Pseudomonas aeruginosa Efflux Pump Contributing to Aminoglycoside Impermeability
Westbrock-Wadman, S., Sherman, D. R., Hickey, M. J., Coulter, S. N., Zhu, Y. Q., Warrener, P., Nguyen, L. Y., Shawar, R. M., Folger, K. R., & Stover, C. K. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2975 · Cited by 242 · see citing works
Similarity of Tetracycline Resistance Genes Isolated from Fish Farm Bacteria to Those from Clinical Isolates
Furushita, M., Shiba, T., Maeda, T., Yahata, M., Kaneoka, A., Takahashi, Y., Torii, K., Hasegawa, T., & Ohta, M. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.9.5336-5342.2003 · Cited by 240 · see citing works
Inhibitors of efflux pumps in Gram-negative bacteria
Pagès, J., Masi, M., & Barbe, J. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.06.006 · Cited by 239 · see citing works
Efflux Pump-Mediated Intrinsic Drug Resistance in Mycobacterium smegmatis
Li, X.-Z., Zhang, L., & Nikaido, H. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.7.2415-2423.2004 · Cited by 239 · see citing works
Molecular Mechanisms of Fluoroquinolone Resistance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients
Jalal, S., Ciofu, O., Høiby, N., Gotoh, N., & Wretlind, B. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.710-712.2000 · Cited by 236 · see citing works
A Novel MATE Family Efflux Pump Contributes to the Reduced Susceptibility of Laboratory-Derived Staphylococcus aureus Mutants to Tigecycline
McAleese, F., Petersen, P. J., Ruzin, A. V., Dunman, P. M., Murphy, E., Projan, S. J., & Bradford, P. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.5.1865-1871.2005 · Cited by 233 · see citing works
The AcrAB-TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis
Buckley, A. M., Webber, M. A., Cooles, S. W., Randall, L. P., Ragione, R. M. L., Woodward, M. J., & Piddock, L. J. V. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00671.x · Cited by 231 · see citing works
Occurrence of and a possible mechanism for resistance to a quaternary ammonium compound in Listeria monocytogenes
Aase, B., Sundheim, G., Langsrud, S., & Rørvik, L. M. (2000) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(00)00357-3 · Cited by 230 · see citing works
The MexJK Efflux Pump of Pseudomonas aeruginosa Requires OprM for Antibiotic Efflux but Not for Efflux of Triclosan
Chuanchuen, R., Narasaki, C. T., & Schweizer, H. P. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.18.5036-5044.2002 · Cited by 228 · see citing works
Selected Arylpiperazines Are Capable of Reversing Multidrug Resistance in Escherichia coli Overexpressing RND Efflux Pumps
Bohnert, J. A., & Kern, W. V. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.2.849-852.2005 · Cited by 228 · see citing works
Prevalence and Molecular Characterization of Tetracycline Resistance in Enterococcus Isolates from Food
Huys, G. R. B., D'Haene, K., Collard, J., & Swings, J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.3.1555-1562.2004 · Cited by 227 · see citing works
Macrolide Resistance Genes in Enterococcus spp
Portillo, A., Ruiz‐Larrea, F., Zarazaga, M., Alonso, A., Martínez, J. L., & Torres, C. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.4.967-971.2000 · Cited by 227 · see citing works
Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome
Ng, E. Y., Trucksis, M., & Hooper, D. C. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.6.1345 · Cited by 226 · see citing works
Multidrug Efflux Pump AcrAB of Salmonella typhimurium Excretes Only Those β-Lactam Antibiotics Containing Lipophilic Side Chains
Nikaido, H., Basina, M., Nguyen, V., & Rosenberg, E. Y. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.17.4686-4692.1998 · Cited by 224 · see citing works
Antibiotics: Where did we go wrong?
Overbye, K. M., & Barrett, J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03285-4 · Cited by 223 · see citing works
Antimicrobials: Modes of Action and Mechanisms of Resistance
McDermott, P. F., Walker, R. D., & White, D. G. (2003) · International Journal of Toxicology · doi:10.1080/10915810305089 · Cited by 223 · see citing works
Crystal Structure of the Drug Discharge Outer Membrane Protein, OprM, of Pseudomonas aeruginosa
Akama, H., Kanemaki, M., Yoshimura, M., Tomitake Tsukihara, A., Kashiwagi, T., Hiroshi Yoneyama, C., Narita, S., Nakagawa, A., & Nakae, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400445200 · Cited by 220 · see citing works
Multidrug-Resistant Acinetobacter Infections: An Emerging Challenge to Clinicians
Jain, R., & Danziger, L. H. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d592 · Cited by 220 · see citing works
Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa
Lomovskaya, O., Lee, A., Hoshino, K., Ishida, H., Mistry, A., Warren, M. S., Boyer, E., Chamberland, S., & LEE, V. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.6.1340 · Cited by 219 · see citing works
Heterogeneity among Virulence and Antimicrobial Resistance Gene Profiles of Extraintestinal Escherichia coli Isolates of Animal and Human Origin
Maynard, C., Békal, S., Sanschagrin, F., Lévesque, R. C., Brousseau, R., Masson, L., Larivière, S., & Harel, J. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.12.5444-5452.2004 · Cited by 218 · see citing works
Characterization of Chloramphenicol and Florfenicol Resistance in Escherichia coli Associated with Bovine Diarrhea
White, D. G., Hudson, C. R., Maurer, J. J., Ayers, S. L., Zhao, S., Lee, M. D., Bolton, L. F., Foley, T., & Sherwood, J. S. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.12.4593-4598.2000 · Cited by 216 · see citing works
Molecular characterization of the lincomycin‐production gene cluster of Streptomyces lincolnensis 78‐11
Peschke, U., Schmidt, H., Zhang, H., & Piepersberg, W. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02338.x · Cited by 216 · see citing works
Negative Regulation of the Pseudomonas aeruginosa Outer Membrane Porin OprD Selective for Imipenem and Basic Amino Acids
Ochs, M. M., McCusker, M. P., Bains, M., & Hancock, R. E. W. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.5.1085 · Cited by 216 · see citing works
Plasmid-Encoded Multidrug Efflux Pump Conferring Resistance to Olaquindox in Escherichia coli
Hansen, L. H., Johannesen, E., Burmølle, M., Sørensen, A. H., & Sørensen, S. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3332-3337.2004 · Cited by 214 · see citing works
A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus
Gibbons, S. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg044 · Cited by 213 · see citing works
Ineffectiveness of Topoisomerase Mutations in Mediating Clinically Significant Fluoroquinolone Resistance in Escherichia coli in the Absence of the AcrAB Efflux Pump
Oethinger, M. D., Kern, W. V., Jellen-Ritter, A., McMurry, L. M., & Levy, S. B. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.1.10-13.2000 · Cited by 213 · see citing works
Genome-Wide Transcriptional Response of Chemostat-Cultured Escherichia coli to Zinc
Lee, L. J., Barrett, J. A., & Poole, R. K. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.3.1124-1134.2005 · Cited by 213 · see citing works
A Gonococcal Efflux Pump System Enhances Bacterial Survival in a Female Mouse Model of Genital Tract Infection
Jerse, A. E., Sharma, N. D., Simms, A. N., Crow, E. T., Snyder, L. A. S., & Shafer, W. M. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.5576-5582.2003 · Cited by 209 · see citing works
Characterization of VariantSalmonellaGenomic Island 1 Multidrug Resistance Regions from Serovars Typhimurium DT104 and Agona
Boyd, D., Cloeckaert, A., Chaslus-Dancla, E., & Mulvey, M. R. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1714-1722.2002 · Cited by 209 · see citing works
Fitness of in vitro selected Pseudomonas aeruginosanalB and nfxB multidrug resistant mutants
Sánchez, P. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf185 · Cited by 209 · see citing works
Macrolides and ketolides: azithromycin, clarithromycin, telithromycin
Zuckerman, J. M. (2004) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2004.04.010 · Cited by 208 · see citing works
Cloning and Characterization of SmeDEF, a Novel Multidrug Efflux Pump from Stenotrophomonas maltophilia
Alonso, A., & Martínez, J. L. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.11.3079-3086.2000 · Cited by 207 · see citing works
Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae bloodstream infection: risk factors and clinical outcome
Du, B., Long, Y., Liu, H., Chen, D., Liu, D., Xu, Y., & Xie, X.-L. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1521-1 · Cited by 207 · see citing works
Lincomycin, clindamycin and their applications
Spížek, J., & Řezanka, T. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1545-7 · Cited by 206 · see citing works
Interactions underlying assembly of the Escherichia coli AcrAB–TolC multidrug efflux system
Touzé, T., Eswaran, J., Bokma, E., Koronakis, E., Hughes, C., & Koronakis, V. E. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04158.x · Cited by 205 · see citing works
Characterization of In53, a Class 1 Plasmid- and Composite Transposon-Located Integron ofEscherichia coliWhich Carries an Unusual Array of Gene Cassettes
Naas, T., Mikami, Y., Imai, T., Poirel, L., & Nordmann, P. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.1.235-249.2001 · Cited by 205 · see citing works
Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci
Moken, M. C., McMurry, L. M., & Levy, S. B. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.12.2770 · Cited by 204 · see citing works
Carbapenem Resistance Mechanisms in Pseudomonas aeruginosa Clinical Isolates
Pai, H., Kim, J., Kim, J. M., Lee, J., Choe, K. W., & Gotoh, N. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.2.480-484.2001 · Cited by 204 · see citing works
Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in Klebsiella pneumoniae
Ruzin, A. V., Visalli, M. A., Keeney, D. R., & Bradford, P. A. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.1017-1022.2005 · Cited by 203 · see citing works
Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa
Hirai, K., Suzue, S., Irikura, T., Iyobe, S., & Mitsuhashi, S. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.4.582 · Cited by 201 · see citing works
Outer Membranes and Efflux: The Path to Multidrug Resistance in Gram- Negative Bacteria
Poole, K. (2002) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201023378454 · Cited by 198 · see citing works
Self-citation
Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus
Littlejohn, T. G. (1992) · FEMS Microbiology Letters · doi:10.1016/0378-1097(92)90439-u · Cited by 197 · see citing works
Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp.
Payot, S., Bolla, J., Corcoran, D., Fanning, S., Mégraud, F., & Zhang, Q. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.12.032 · Cited by 192 · see citing works
Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals
Schmitz, F., Sadurski, R., Kray, A., Boos, M., Geisel, R., Köhrer, K., Verhoef, J., & Fluit, A. C. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/45.6.891 · Cited by 192 · see citing works
AcrB Multidrug Efflux Pump of Escherichia coli : Composite Substrate-Binding Cavity of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity
Yu, E. W., Aires, J., & Nikaido, H. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.19.5657-5664.2003 · Cited by 192 · see citing works
Bile Salts Modulate Expression of the CmeABC Multidrug Efflux Pump inCampylobacter jejuni
Lin, J., Cagliero, C., Guo, B., Barton, Y.-W., Maurel, M. C., Payot, S., & Zhang, Q. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.21.7417-7424.2005 · Cited by 191 · see citing works
AcrAB-TolC Directs Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium DT104
Baucheron, S., Tyler, S. D., Boyd, D. A., Mulvey, M. R., Chaslus-Dancla, E., & Cloeckaert, A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3729-3735.2004 · Cited by 191 · see citing works
The Phytoalexin-Inducible Multidrug Efflux Pump AcrAB Contributes to Virulence in the Fire Blight Pathogen, Erwinia amylovora
Burse, A., Weingart, H., & Ullrich, M. S. (2004) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi.2004.17.1.43 · Cited by 191 · see citing works
Multiple Antibiotic Resistance in Stenotrophomonas maltophilia : Involvement of a Multidrug Efflux System
Zhang, L., Li, X.-Z., & Poole, K. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.2.287-293.2000 · Cited by 190 · see citing works
Self-citation
Distribution and in-vitro transfer of tetracycline resistance determinants in clinical and aquatic Acinetobacter strains
Guardabassi, L., Dijkshoorn, L., Collard, J., Olsen, J. E., & Dalsgaard, A. (2000) · Journal of Medical Microbiology · doi:10.1099/0022-1317-49-10-929 · Cited by 189 · see citing works
Postadaptational Resistance to Benzalkonium Chloride and Subsequent Physicochemical Modifications of Listeria monocytogenes
To, M. S., Favrin, S. J., Romanova, N. A., & Griffiths, M. W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.11.5258-5264.2002 · Cited by 189 · see citing works
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol
Colangeli, R., Helb, D., Sridharan, S., Sun, J., Basil, M. V., Hazbón, M. H., Harbacheuski, R., Megjugorac, N. J., Jacobs, W. R., Holzenburg, A., et al. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04510.x · Cited by 188 · see citing works
Multidrug Resistance Is Mediated by Large Plasmids Carrying a Class 1 Integron in the Emergent Salmonella enterica Serotype [4,5,12:i:−]
Guerra, B., Soto, S. M., Argüelles, J. M., & Mendoza, M. C. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.4.1305-1308.2001 · Cited by 188 · see citing works
Molecular Cloning and Characterization of Tap, a Putative Multidrug Efflux Pump Present inMycobacterium fortuitumandMycobacterium tuberculosis
Aínsa, J. A., Blokpoel, M. C. J., Otal, I., Young, D. B., Smet, K. A. L. D., & Martı́n, C. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.22.5836-5843.1998 · Cited by 188 · see citing works
Plasmid-Mediated 16S rRNA Methylase in Serratia marcescens Conferring High-Level Resistance to Aminoglycosides
Doi, Y., Yokoyama, K., Yamane, K., Wachino, J., Shibata, N., Yagi, T., Shibayama, K., Kato, H., & Arakawa, Y. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.2.491-496.2004 · Cited by 187 · see citing works
The AcrB Multidrug Transporter Plays a Major Role in High-Level Fluoroquinolone Resistance in Salmonella enterica Serovar Typhimurium Phage Type DT204
Baucheron, S., Imberechts, H., Chaslus-Dancla, E., & Cloeckaert, A. (2002) · Microbial Drug Resistance · doi:10.1089/10766290260469543 · Cited by 187 · see citing works
Overexpression of the Multidrug Efflux Pumps MexCD-OprJ and MexEF-OprN Is Associated with a Reduction of Type III Secretion in Pseudomonas aeruginosa
Linares, J. F., López, J. A., Camafeita, E., Albar, J. P., Rojo, F., & Martínez, J. L. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.4.1384-1391.2005 · Cited by 184 · see citing works
NorM of Vibrio parahaemolyticus Is an Na + -Driven Multidrug Efflux Pump
Morita, Y., Kataoka, A., Shiota, S., Mizushima, T., & Tsuchiya, T. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.23.6694-6697.2000 · Cited by 182 · see citing works
Contribution of the MexXY Multidrug Transporter to Aminoglycoside Resistance in Pseudomonas aeruginosa Clinical Isolates
Sobel, M. L., McKay, G. A., & Poole, K. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.10.3202-3207.2003 · Cited by 181 · see citing works
Self-citation
Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins
Bissonnette, L., Champetier, S., Buisson, J. P., & Roy, P. H. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.14.4493-4502.1991 · Cited by 180 · see citing works
Antimicrobial susceptibility and molecular characterization of avian pathogenic Escherichia coli isolates
Zhao, S., Maurer, J. J., Hubert, S. K., Villena, J. F. D., McDermott, P. F., Meng, J., Ayers, S. L., English, L., & White, D. G. (2005) · Veterinary Microbiology · doi:10.1016/j.vetmic.2005.01.021 · Cited by 180 · see citing works
Multidrug resistance ABC transporters
Chang, G. A. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01085-8 · Cited by 178 · see citing works
The complete nucleotide sequence of the resistance plasmid R478: defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics
Gilmour, M. W., Thomson, N. R., Sanders, M. J., Parkhill, J., & Taylor, D. E. (2004) · Plasmid · doi:10.1016/j.plasmid.2004.06.006 · Cited by 178 · see citing works
MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides
Hocquet, D., Vogne, C., Garch, F. E., Véjux, A., Gotoh, N., Lee, A., Lomovskaya, O., & Plésiat, P. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.4.1371-1375.2003 · Cited by 178 · see citing works
Multiple antibiotic resistance in Stenotrophomonas maltophilia
Alonso, A., & Martínez, J. L. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.5.1140 · Cited by 177 · see citing works
Mutations in PA2491 ( mexS ) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa
Sobel, M. L., Neshat, S., & Poole, K. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.4.1246-1253.2005 · Cited by 177 · see citing works
Self-citation
Quinoline Derivatives as Promising Inhibitors of Antibiotic Efflux Pump in Multidrug Resistant Enterobacter Aerogenes Isolates
Mahamoud, A., Chevalier, J., Davin‐Regli, A., Barbe, J., & Pagès, J. (2006) · Current Drug Targets · doi:10.2174/138945006777709557 · Cited by 177 · see citing works
Overexpression of the MtrC-MtrD-MtrE Efflux Pump Due to an mtrR Mutation Is Required for Chromosomally Mediated Penicillin Resistance in Neisseria gonorrhoeae
Veal, W. L., Nicholas, R. A., & Shafer, W. M. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.20.5619-5624.2002 · Cited by 176 · see citing works
Expression control and specificity of the basic amino acid exporter LysE of Corynebacterium glutamicum
Bellmann, A., Vrljic, M., Pátek, M., Sahm, H., Krämer, R., & Eggeling, L. (2001) · Microbiology · doi:10.1099/00221287-147-7-1765 · Cited by 176 · see citing works
Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium
Prouty, A. M., Brodsky, I. E., Falkow, S., & Gunn, J. S. (2004) · Microbiology · doi:10.1099/mic.0.26769-0 · Cited by 176 · see citing works
Tetracycline Resistance inChlamydia suisMediated by Genomic Islands Inserted into the Chlamydialinv-Like Gene
Dugan, J. W., Rockey, D. D., Jones, L., & Andersen, A. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3989-3995.2004 · Cited by 175 · see citing works
Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis
Pasca, M. R., Guglierame, P., Arcesi, F., Bellinzoni, M., Rossi, E. D., & Riccardi, G. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.8.3175-3178.2004 · Cited by 173 · see citing works
Identification of a major facilitator protein from Escherichia coli involved in efflux of metabolites of the cysteine pathway
Daßler, T., Maier, T., Winterhalter, C., & Böck, A. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01924.x · Cited by 172 · see citing works
Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli
Kern, W. V., Steinke, P., Schumacher, A., Schuster, S., von Baum, H., & Bohnert, J. A. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki445 · Cited by 172 · see citing works
Inhibitors of Bacterial Efflux Pumps as Adjuvants in Antibiotic Treatments and Diagnostic Tools for Detection of Resistance by Efflux
Françoise Van Bambeke, A., Pagès, J., & LEE, V. J. (2006) · Recent Patents on Anti-Infective Drug Discovery · doi:10.2174/157489106777452692 · Cited by 171 · see citing works
Hospital Mortality for Patients With Bacteremia Due to Staphylococcus aureus or Pseudomonas aeruginosa
Osmon, S., Ward, S., Fraser, V. J., & Kollef, M. H. (2004) · CHEST Journal · doi:10.1378/chest.125.2.607 · Cited by 171 · see citing works
Role of AcrR and RamA in Fluoroquinolone Resistance in Clinical Klebsiella pneumoniae Isolates from Singapore
Schneiders, T., Amyes, S. G. B., & Levy, S. B. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.9.2831-2837.2003 · Cited by 169 · see citing works
Incidence of Antibiotic Resistance in Campylobacter jejuni Isolated in Alberta, Canada, from 1999 to 2002, with Special Reference to tet (O)-Mediated Tetracycline Resistance
Gibreel, A., Tracz, D. M., Nonaka, L., Ngo, T., Connell, S. R., & Taylor, D. E. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.9.3442-3450.2004 · Cited by 169 · see citing works

Flagged first, then by citations

Sorted by citations

Origins and evolution of antibiotic resistance
Davies, J., & Davies, D. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-10 · Cited by 5,784 · see citing works
Mechanisms of Antibiotic Resistance
Munita, J. M., & Arias, C. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0016-2015 · Cited by 2,782 · see citing works
Antimicrobial Resistance: A Growing Serious Threat for Global Public Health
Salam, M. A., Al-Amin, M. Y., Salam, M. T., Pawar, J. S., Akhter, N., Rabaan, A. A., & Alqumber, M. A. A. (2023) · Healthcare · doi:10.3390/healthcare11131946 · Cited by 2,622 · see citing works
Call of the wild: antibiotic resistance genes in natural environments
Allen, H. K., Donato, J., Wang, H. H., Cloud-Hansen, K. A., Davies, J., & Handelsman, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2312 · Cited by 2,007 · see citing works
Multidrug Resistance in Bacteria
Nikaido, H. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.082907.145923 · Cited by 1,694 · see citing works
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
Li, X.-Z., Plésiat, P., & Nikaido, H. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00117-14 · Cited by 1,648 · see citing works
Multidrug-resistance efflux pumps ? not just for resistance
Piddock, L. J. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1464 · Cited by 1,523 · see citing works
Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems
Davidson, A. L., Dassa, E., Orelle, C., & Chen, J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-07 · Cited by 1,422 · see citing works
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231 · see citing works
Comprehensive review of antimicrobial activities of plant flavonoids
Górniak, I., Bartoszewski, R., & Króliczewski, J. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-018-9591-z · Cited by 1,268 · see citing works
Global Challenge of Multidrug-Resistant Acinetobacter baumannii
Pérez, F., Hujer, A. M., Hujer, K. M., Decker, B. K., Rather, P. N., & Bonomo, R. A. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01464-06 · Cited by 1,138 · see citing works
Green synthesis of silver nanoparticles: biomolecule-nanoparticle organizations targeting antimicrobial activity
Roy, A., Bulut, O., Some, S., Mandal, A. K., & Yilmaz, M. D. (2019) · RSC Advances · doi:10.1039/c8ra08982e · Cited by 1,066 · see citing works
Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens
Peterson, E., & Kaur, P. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02928 · Cited by 1,021 · see citing works
Efflux-Mediated Drug Resistance in Bacteria
Li, X.-Z., & Nikaido, H. (2009) · Drugs · doi:10.2165/11317030-000000000-00000 · Cited by 976 · see citing works
The worldwide emergence of plasmid-mediated quinolone resistance
Robicsek, A. A., Jacoby, G. A., & Hooper, D. C. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70599-0 · Cited by 965 · see citing works
Resistance of bacterial biofilms to disinfectants: a review
Bridier, A., Briandet, R., Thomas, V., & Dubois‐Brissonnet, F. (2011) · Biofouling · doi:10.1080/08927014.2011.626899 · Cited by 952 · see citing works
The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
Pagès, J.-M., James, C. E., & Winterhalter, M. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1994 · Cited by 939 · see citing works
Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat
Strahilevitz, J., Jacoby, G. A., Hooper, D. C., & Robicsek, A. A. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00016-09 · Cited by 926 · see citing works
Efflux-Mediated Drug Resistance in Bacteria
Li, X.-Z., & Nikaido, H. (2004) · Drugs · doi:10.2165/00003495-200464020-00004 · Cited by 803 · see citing works
Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence
Christaki, E., Marcou, M., & Tofarides, A. G. (2019) · Journal of Molecular Evolution · doi:10.1007/s00239-019-09914-3 · Cited by 818 · see citing works
Carbapenem Resistance: A Review
Codjoe, F. S., & Donkor, E. S. (2017) · Medical Sciences · doi:10.3390/medsci6010001 · Cited by 758 · see citing works
How to manage Pseudomonas aeruginosa infections
Bassetti, M., Vena, A., Croxatto, A., Righi, E., & Guery, B. P. (2018) · Drugs in Context · doi:10.7573/dic.212527 · Cited by 750 · see citing works
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents
Singh, S., Singh, S. K., Chowdhury, I., & Singh, R. (2017) · The Open Microbiology Journal · doi:10.2174/1874285801711010053 · Cited by 696 · see citing works
Lipopolysaccharide modification in Gram-negative bacteria during chronic infection
Maldonado, R. F., Sá‐Correia, I., & Valvano, M. A. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw007 · Cited by 694 · see citing works
Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance
Jennings, M. C., Minbiole, K. P. C., & Wuest, W. M. (2015) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5b00047 · Cited by 651 · see citing works
P-glycoprotein Inhibition for Optimal Drug Delivery
Amin, M. L. (2013) · Drug Target Insights · doi:10.4137/dti.s12519 · Cited by 635 · see citing works
Biofilm-Specific Antibiotic Resistance
Mah, T. (2012) · Future Microbiology · doi:10.2217/fmb.12.76 · Cited by 589 · see citing works
Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives
Garneau‐Tsodikova, S., & Labby, K. J. (2015) · MedChemComm · doi:10.1039/c5md00344j · Cited by 582 · see citing works
Natural Products as Platforms To Overcome Antibiotic Resistance
Rossiter, S. E., Fletcher, M. H., & Wuest, W. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00283 · Cited by 622 · see citing works
Efflux pumps as antimicrobial resistance mechanisms
Poole, K. (2007) · Annals of Medicine · doi:10.1080/07853890701195262 · Cited by 561 · see citing works
Self-citation
Bacterial efflux pump inhibitors from natural sources
Stavri, M., Piddock, L. J. V., & Gibbons, S. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl460 · Cited by 547 · see citing works
Antimicrobial resistance, mechanisms and its clinical significance
Abushaheen, M. A., Muzaheed, M., Fatani, A. J., Alosaimi, M., Mansy, W., George, M., Acharya, S., Rathod, S., Divakar, D. D., Jhugroo, C., et al. (2020) · Disease-a-Month · doi:10.1016/j.disamonth.2020.100971 · Cited by 513 · see citing works
Role of bacterial efflux pumps in biofilm formation
Alav, I., Sutton, J. M., & Rahman, K. M. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky042 · Cited by 504 · see citing works
Antibiotic Resistance and the MRSA Problem
Vestergaard, M. R., Frees, D., & Ingmer, H. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0057-2018 · Cited by 514 · see citing works
Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes
Pamp, S. J., Gjermansen, M., Johansen, H. K., & Tolker‐Nielsen, T. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06152.x · Cited by 486 · see citing works
Bacterial Community Shift Drives Antibiotic Resistance Promotion during Drinking Water Chlorination
Jia, S., Shi, P., Hu, Q., Li, B. J., Zhang, T., & Zhang, X. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b03521 · Cited by 476 · see citing works
Practical applications and feasibility of efflux pump inhibitors in the clinic—A vision for applied use
Lomovskaya, O., & Bostian, K. A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.12.008 · Cited by 461 · see citing works
Editorial: Assessing the antimicrobial susceptibility of bacteria obtained from animals
Schwarz, Š., Silley, P., Simjee, S., Woodford, N., van Duijkeren, E., Johnson, A. P., & Gaastra, W. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq037 · Cited by 444 · see citing works
Antibiotic interactions that select against resistance
Chait, R., Craney, A., & Kishony, R. (2007) · Nature · doi:10.1038/nature05685 · Cited by 439 · see citing works
Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice
Swanson, K. S., Dowd, S. E., Suchodolski, J. S., Middelbos, I. S., Vester, B. M., Barry, K. A., Nelson, K. E., Torralba, M., Henrissat, B., Coutinho, P. M., et al. (2010) · The ISME Journal · doi:10.1038/ismej.2010.162 · Cited by 422 · see citing works
Mechanisms of antibiotic resistance
Munita, J. M., & Arias, C. A. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch17 · Cited by 421 · see citing works
Aminoglycoside Antibiotics in the 21st Century
Becker, B., & Cooper, M. A. (2012) · ACS Chemical Biology · doi:10.1021/cb3005116 · Cited by 420 · see citing works
Plant Antimicrobial Agents and Their Effects on Plant and Human Pathogens
González-Lamothe, R., Mitchell, G., Gattuso, M., Diarra, M. S., Malouin, F., & Bouarab, K. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10083400 · Cited by 423 · see citing works
Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool
Schlüter, A., Szczepanowski, R., Pühler, A., & Top, E. M. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00074.x · Cited by 400 · see citing works
Quaternary ammonium disinfectants: microbial adaptation, degradation and ecology
Tezel, U., & Pavlostathis, S. G. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.03.018 · Cited by 389 · see citing works
Cell envelope stress response in Gram-positive bacteria
Jordan, S., Hutchings, M. I., & Mascher, T. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00091.x · Cited by 387 · see citing works
Involvement of a Novel Efflux System in Biofilm-Specific Resistance to Antibiotics
Zhang, L., & Mah, T. (2008) · Journal of Bacteriology · doi:10.1128/jb.01655-07 · Cited by 387 · see citing works
Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns
Williamson, D. A., Carter, G. P., & Howden, B. P. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00112-16 · Cited by 376 · see citing works
Updates on the pathogenicity status of Pseudomonas aeruginosa
Azam, M. W., & Khan, A. U. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.07.003 · Cited by 377 · see citing works
Engineering multiple genomic deletions in Gram‐negative bacteria: analysis of the multi‐resistant antibiotic profile of Pseudomonas putida KT2440
Martínez‐García, E., & de Lorenzo, V. (2011) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02538.x · Cited by 354 · see citing works
Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation
Kvist, M., Hancock, V., & Klemm, P. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01310-08 · Cited by 353 · see citing works
Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them
Khameneh, B., Diab, R., Ghazvini, K., & Bazzaz, B. S. F. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.009 · Cited by 348 · see citing works
Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in Bacteria
Lubelski, J., Konings, W. N., & Driessen, A. J. M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00001-07 · Cited by 339 · see citing works
Molecular understanding of aminoglycoside action and resistance
Jana, S., & Deb, J. K. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0279-0 · Cited by 335 · see citing works
Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria
Pagès, J., & Amaral, L. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.12.011 · Cited by 328 · see citing works
β-Lactam antibiotic resistance: a current structural perspective
Wilke, M. S., Lovering, A. L., & Strynadka, N. C. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.08.016 · Cited by 383 · see citing works
Multidrug-resistantPseudomonas aeruginosaandAcinetobacter baumannii: resistance mechanisms and implications for therapy
Zavascki, A. P., Carvalhaes, C. G., Picão, R. C., & Gales, A. C. (2009) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.09.108 · Cited by 312 · see citing works
Proximate and ultimate causes of the bactericidal action of antibiotics
Baquero, F., & Levin, B. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00443-1 · Cited by 270 · see citing works
Modes of action of three disinfectant active substances: A review
Wessels, S., & Ingmer, H. (2013) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2013.09.006 · Cited by 297 · see citing works
Antibiotic strategies in the era of multidrug resistance
Karam, G. H., Chastre, J. E., Wilcox, M. H., & Vincent, J. (2016) · Critical Care · doi:10.1186/s13054-016-1320-7 · Cited by 297 · see citing works
Tigecycline: A Critical Analysis
Stein, G. E., & Craig, W. A. (2006) · Clinical Infectious Diseases · doi:10.1086/505494 · Cited by 295 · see citing works
The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria
Lamers, R. P., Cavallari, J. F., & Burrows, L. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060666 · Cited by 293 · see citing works
Unravelling the mechanisms of antibiotic and heavy metal resistance co-selection in environmental bacteria
Gillieatt, B. F., & Coleman, N. V. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae017 · Cited by 293 · see citing works
ARGs-OAP v3.0: Antibiotic-Resistance Gene Database Curation and Analysis Pipeline Optimization
Yin, X., Zheng, X., Li, L., Zhang, A., Jiang, X., & Zhang, T. (2022) · Engineering · doi:10.1016/j.eng.2022.10.011 · Cited by 293 · see citing works
RND-type drug eﬄux pumps from Gram-negative bacteria: molecular mechanism and inhibition
Venter, H., Mowla, R., Ohene‐Agyei, T., & Ma, S. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00377 · Cited by 286 · see citing works
Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance
Durão, P., Balbontín, R., & Gordo, I. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.01.005 · Cited by 273 · see citing works
Antibiotic Adjuvants: Make Antibiotics Great Again!
Douafer, H., Andrieu, V., Phanstiel, O., & Brunel, J. M. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01781 · Cited by 272 · see citing works
Infection microenvironment-related antibacterial nanotherapeutic strategies
Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 269 · see citing works
Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance
Mohapatra, S., Yutao, L., Goh, S. G., Ng, C., Luhua, Y., Trần, N. H., & Gin, K. Y. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.130393 · Cited by 274 · see citing works
Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy
Mahamoud, A., Chevalier, J., Alibert, S., Kern, W. V., & Pagès, J. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl493 · Cited by 270 · see citing works
Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update
Blair, J. M. A., & Piddock, L. J. V. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.07.003 · Cited by 266 · see citing works
Evolutionary consequences of antibiotic use for the resistome, mobilome and microbial pangenome
Gillings, M. R. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00004 · Cited by 264 · see citing works
The Resistome of Pseudomonas aeruginosa in Relationship to Phenotypic Susceptibility
Kos, V. N., Déraspe, M., McLaughlin, R. E., Whiteaker, J. D., Roy, P. H., Alm, R. A., Corbeil, J., & Gardner, H. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03954-14 · Cited by 264 · see citing works
Mechanisms of Antibiotic Resistance in Burkholderia Pseudomallei : Implications for Treatment of Melioidosis
Schweizer, H. P. (2012) · Future Microbiology · doi:10.2217/fmb.12.116 · Cited by 258 · see citing works
Biocide tolerance in bacteria
Ortega, E., Fernández-Fuentes, M. A., Burgos, M. J. G., Abriouel, H., Pulido, R. P., & Gálvez, A. (2013) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.12.028 · Cited by 255 · see citing works
Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections
Zhu, Y., Hao, W., Wang, X., Ouyang, J., Deng, X., Yu, H., & Wang, Y. (2022) · Medicinal Research Reviews · doi:10.1002/med.21879 · Cited by 254 · see citing works
Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review
Belay, W. Y., Getachew, M., Tegegne, B. A., Teffera, Z. H., Dagne, A., Zeleke, T. K., Abebe, R. B., Gedif, A. A., Fenta, A., Yirdaw, G., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1444781 · Cited by 278 · see citing works
Pseudomonas aeruginosaIncreases Formation of Multidrug-Tolerant Persister Cells in Response to Quorum-Sensing Signaling Molecules
Möker, N., Dean, C. R., & Tao, J. (2010) · Journal of Bacteriology · doi:10.1128/jb.01231-09 · Cited by 243 · see citing works
New strategies for combating multidrug-resistant bacteria
Wright, G. D., & Sutherland, A. D. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.04.004 · Cited by 244 · see citing works
Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens
Chang, H., Cohen, T., Grad, Y. H., Hanage, W. P., O’Brien, T., & Lipsitch, M. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00039-14 · Cited by 242 · see citing works
Phytochemicals for Bacterial Resistance - Strengths, Weaknesses and Opportunities
Gibbons, S. (2008) · Planta Medica · doi:10.1055/s-2008-1074518 · Cited by 238 · see citing works
Assessing the antimicrobial susceptibility of bacteria obtained from animals
Schwarz, Š., Silley, P., Simjee, S., Woodford, N., van Duijkeren, E., Johnson, A. P., & Gaastra, W. (2009) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.12.013 · Cited by 236 · see citing works
Aminoglycosides versus bacteria – a description of the action, resistance mechanism, and nosocomial battleground
Shakil, S., Khan, R., Zarrilli, R., & Khan, A. U. (2007) · Journal of Biomedical Science · doi:10.1007/s11373-007-9194-y · Cited by 230 · see citing works
Long-Term Exposure to Benzalkonium Chloride Disinfectants Results in Change of Microbial Community Structure and Increased Antimicrobial Resistance
Tandukar, M., Oh, S., Tezel, U., Konstantinidis, K. T., & Pavlostathis, S. G. (2013) · Environmental Science & Technology · doi:10.1021/es401507k · Cited by 229 · see citing works
Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem
Rehman, A., Patrick, W. M., & Lamont, I. L. (2019) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000873 · Cited by 229 · see citing works
Nonoptimal microbial response to antibiotics underlies suppressive drug interactions
Bollenbach, T., Quan, S., Chait, R., & Kishony, R. (2009) · Cell · doi:10.1016/j.cell.2009.10.025 · Cited by 227 · see citing works
RND multidrug efflux pumps: what are they good for?
Alvarez‐Ortega, C., Olivares‐Pacheco, J., & Martínez, J. L. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00007 · Cited by 227 · see citing works
Degradation and Deactivation of Bacterial Antibiotic Resistance Genes during Exposure to Free Chlorine, Monochloramine, Chlorine Dioxide, Ozone, Ultraviolet Light, and Hydroxyl Radical
He, H., Zhou, P., Shimabuku, K. K., Fang, X., Li, S., Lee, Y., & Dodd, M. C. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b04393 · Cited by 227 · see citing works
Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria
Arzanlou, M., Chai, W. C., & Venter, H. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160063 · Cited by 222 · see citing works
Expression of Multidrug Efflux Pump Genes acrAB-tolC , mdfA , and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance
Swick, M. C., Morgan‐Linnell, S. K., Carlson, K. M., & Zechiedrich, L. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00996-10 · Cited by 220 · see citing works
Swarming motility: a multicellular behaviour conferring antimicrobial resistance
Lai, S., Tremblay, J., & Déziel, É. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01747.x · Cited by 219 · see citing works
Structure and Mechanism of RND‐Type Multidrug Efflux Pumps
Nikaido, H. (2011) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470920541.ch1 · Cited by 216 · see citing works
Metagenomic analysis reveals the microbiome and resistome in migratory birds
Cao, J., Hu, Y., Liu, F., Wang, Y., Bi, Y., Lv, N., Li, J., Zhu, B., & Gao, G. F. (2020) · Microbiome · doi:10.1186/s40168-019-0781-8 · Cited by 214 · see citing works
Aminoglycoside antibiotics: old drugs and new therapeutic approaches
Hermann, T. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7034-x · Cited by 213 · see citing works
Antibiotic Administration Routes Significantly Influence the Levels of Antibiotic Resistance in Gut Microbiota
Zhang, L., Huang, Y., Zhou, Y., Buckley, T., & Wang, H. H. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00670-13 · Cited by 203 · see citing works
Advances in antimicrobial photodynamic inactivation at the nanoscale
Kashef, N., Huang, Y., & Hamblin, M. R. (2017) · Nanophotonics · doi:10.1515/nanoph-2016-0189 · Cited by 209 · see citing works
Efflux pump inhibitors of clinically relevant multidrug resistant bacteria
Lamut, A., Mašič, L. P., Kikelj, D., & Tomašič, T. (2019) · Medicinal Research Reviews · doi:10.1002/med.21591 · Cited by 204 · see citing works
Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin
Zhanel, G. G., Lawson, C. D., Zelenitsky, S. A., Findlay, B., Schweizer, F., Adam, H. J., Walkty, A. J., Rubinstein, E., Gin, A. S., Hoban, D. J., et al. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.12.25 · Cited by 201 · see citing works
Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation
Serio, A. W., Keepers, T. R., Andrews, L. D., & Krause, K. M. (2018) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0002-2018 · Cited by 198 · see citing works
MexXY multidrug efflux system of Pseudomonas aeruginosa
Morita, Y., Tomida, J., & Kawamura, Y. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00408 · Cited by 197 · see citing works

Authors: Poole, K.
Affiliations: Queen's University (CA)
Corresponding author: Poole, Keith
ORCID: Poole, Keith
Venue: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press (OUP)
Published: 2005-05-24
Volume: 56
Issue: 1
Pages: 20-51
ISSN: 0305-7453 (ISSN-L)
1460-2091
DOI: 10.1093/jac/dki171
OpenAlex: W2131256712
Cited by: 1,082
References: 733
Citations by year: 2026: 37 · 2025: 50 · 2024: 54 · 2023: 54 · 2022: 43 · 2021: 63 · 2020: 57 · 2019: 52 · 2018: 48 · 2017: 52 · 2016: 70 · 2015: 52 · 2014: 61 · 2013: 57 · 2012: 54
FWCI: 2.24
Type: journal article
Language: en
Open access: closed
Locations: Journal of Antimicrobial Chemotherapy (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: efflux-mediated resistance, antimicrobial resistance, multidrug efflux pumps, biocide resistance, multidrug resistance, plasmid-encoded resistance genes, integrons, transposable elements, mobile genetic elements, efflux pump inhibitors, Gram-negative bacteria, intrinsic resistance, acquired resistance
MeSH terms: Aminoglycosides, Anti-Bacterial Agents, Biological Transport, Chloramphenicol, Tetracycline, Fluoroquinolones, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Efflux-mediated antimicrobial resistance

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks