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Characterization of Variant Salmonella Genomic Island 1 Multidrug Resistance Regions from Serovars Typhimurium DT104 and Agona
Open accessAbstract
Strains of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 (DT104) and S. enterica serovar Agona (Agona) have been found to harbor Salmonella genomic island 1 (SGI1), a 43-kb genomic region that contains many of the drug resistance genes. Such strains are resistant to ampicillin (pse-1), chloramphenicol/florfenicol (floR), streptomycin/spectinomycin (aadA2), sulfonamides (sul1), and tetracycline [tet(G)] (commonly called the ACSSuT phenotype). All five resistance genes are found in a 13-kb multidrug resistance (MDR) region consisting of an unusual class I integron structure related to In4. We examined DT104 and Agona strains that exhibited other resistance phenotypes to determine if the resistance genes were associated with variant SGI1 MDR regions. All strains were found to harbor variant SGI1-like elements by using a combination of Southern hybridization, PCR mapping, and sequencing. Variant SGI1-like elements were found with MDR regions consisting of (i) an integron consisting of the SGI1 MDR region with the addition of a region containing a putative transposase gene (orf513) and dfrA10 located between duplicated qacE Δ 1/sulI genes (SGI1-A; ACSSuTTm); (ii) an integron with either an aadA2(SSu) or a pse-1(ASu) cassette (SGI1-C and SGI1-B, respectively); (iii) an integron consisting of the SGI1-C MDR region plus an orf513/dfrA10 region as in SGI1-A (SGI1-D; ASSuTm; ampicillin resistance due to a TEM β-lactamase); and (iv) an integron related to that in SGI1 but which contains a 10-kb inversion between two copies of IS 6100, one which is inserted in floR(SGI1-E; ASSuT). We hypothesize that the MDR of SGI1 is subject to recombinational events that lead to the various resistance phenotypes in the Salmonella strains in which it is found.
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“SXT constins are present in virtually all recent clinical V. cholerae isolates from Asia, and SXT variants are arising in a manner similar to the Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona (6).”
From Antibiotic Resistance Conferred by a Class I Integron and SXT Constin in Vibrio cholerae O1 Strains Isolated in Laos (2004) · cites this paper as [6]
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Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-15 · Cited by 1,220
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BackgroundSelf-citation
Metadata
- Authors
- Boyd, D., Cloeckaert, A., Chaslus-Dancla, E., & Mulvey, M. R.
- Affiliations
- Health Canada (CA)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2002-06
- Volume
- 46
- Issue
- 6
- Pages
- 1714-1722
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC127246
- OpenAlex
- W2123741711
- Cited by
- 209
- References
- 52
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 26.02
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Salmonella genomic island 1, multidrug resistance, Salmonella Typhimurium DT104, Salmonella Agona, class 1 integron, aadA2, floR, qacEΔ1, transposase genes, gene rearrangement, antimicrobial resistance genes
- MeSH terms
- Amino Acid Sequence, Anti-Bacterial Agents, Culture Media, DNA, Bacterial, Drug Resistance, Microbial, Microbial Sensitivity Tests, Terminology as Topic, Phenotype, Salmonella Infections, Sequence Homology, Nucleic Acid, Genomic Library, Drug Resistance, Multiple, Salmonella enterica
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