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Sensitization of Staphylococcus aureus and Escherichia coli to Antibiotics by the Sesquiterpenoids Nerolidol, Farnesol, Bisabolol, and Apritone
Open accessAbstract
The sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone were investigated for their abilities to enhance bacterial permeability and susceptibility to exogenous antimicrobial compounds. Initially, it was observed by flow cytometry that these sesquiterpenoids promoted the intracellular accumulation of the membrane-impermeant nucleic acid stain ethidium bromide by live cells of Lactobacillus fermentum, suggesting that enhanced permeability resulted from disruption of the cytoplasmic membrane. The ability of these sesquiterpenoids to increase bacterial susceptibility to a number of clinically important antibiotics was then investigated. In disk diffusion assays, treatment with low concentrations (0.5 to 2 mM) of nerolidol, bisabolol, or apritone enhanced the susceptibility of Staphylococcus aureus to ciprofloxacin, clindamycin, erythromycin, gentamicin, tetracycline, and vancomycin. Nerolidol and farnesol also sensitized Escherichia coli to polymyxin B. Our results indicate the practical utility of sensitizing bacteria to antimicrobials with sesquiterpenoids that have traditionally been used as flavorants and aroma compounds in the food and perfume industries.
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Cites
Agents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
Quorum Sensing in the Dimorphic Fungus Candida albicans Is Mediated by Farnesol
Hornby, J. M., Jensen, E. C., Lisec, A. D., Tasto, J. J., Jahnke, B., Shoemaker, R., Dussault, P., & Nickerson, K. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.7.2982-2992.2001 · Cited by 983
Cited by
Medically important bacterial-fungal interactions
Peleg, A. Y., Hogan, D. A., & Mylonakis, E. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2313 · Cited by 619
Kamatou, G. P. P., & Viljoen, A. M. (2010) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-009-1483-3 · Cited by 357
Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle
Zore, G. B., Thakre, A. D., Jadhav, S., & Karuppayil, S. M. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.03.008 · Cited by 319
Exploring phytochemicals for combating antibiotic resistance in microbial pathogens
Khare, T., Anand, U., Dey, A., Assaraf, Y. G., Chen, Z.-S., Liu, Z., & Kumar, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720726 · Cited by 281
Dixon, E. F., & Hall, R. A. (2015) · Cellular Microbiology · doi:10.1111/cmi.12490 · Cited by 73
Metadata
- Authors
- Brehm-Stecher, B. F., & Johnson, E. A.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2003-10
- Volume
- 47
- Issue
- 10
- Pages
- 3357-3360
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2165861026
- Cited by
- 284
- References
- 2
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Brehm-Stecher, B. F., & Johnson, E. A. (2003). Sensitization of Staphylococcus aureus and Escherichia coli to Antibiotics by the Sesquiterpenoids Nerolidol, Farnesol, Bisabolol, and Apritone. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.47.10.3357-3360.2003
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