Exploring phytochemicals for combating antibiotic resistance in microbial pathogens
Open accessAbstract
Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens.
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Aqueous root extract of WS corrected T cell population reduction and Th1 cytokine upregulation in chronically stressed mice.
“T cell population reduction and Th1 cytokine upregulation in chronically stressed mice were corrected by aqueous root extract of WS [156].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [156]
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Clean-label alternatives for food preservation: An emerging trend
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Latif, R., & Nawaz, T. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10194-7 · Cited by 180 · see citing works
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Phytochemicals in Drug Discovery—A Confluence of Tradition and Innovation
Chihomvu, P., Ganesan, A., Gibbons, S., Johannson, M., Woollard, K., & Hayes, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168792 · Cited by 155 · see citing works
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RetractedPlasmid-Mediated Transfer of Antibiotic Resistance Genes in Soil
Meng, M., Li, Y., & Yao, H. (2022) · Antibiotics · doi:10.3390/antibiotics11040525 · Cited by 108 · see citing works
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Skin protection from solar ultraviolet radiation using natural compounds: a review
Verma, A., Zanoletti, A., Kareem, K. Y., Adelodun, B., Kumar, P., Ajibade, F. O., Silva, L. F. O., Phillips, A. J., Kartheeswaran, T., Bontempi, E., et al. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01649-4 · Cited by 102 · see citing works
Azizah, N. S., Irawan, B., Kusmoro, J., Safriansyah, W., Farabi, K., Oktavia, D., Doni, F., & Miranti, M. (2023) · Plants · doi:10.3390/plants12244148 · Cited by 117 · see citing works
Tackling Multiple-Drug-Resistant Bacteria With Conventional and Complex Phytochemicals
Suganya, T., Packiavathy, I. A. S. V., Aseervatham, G. S. B., Carmona, A., Rashmi, V., Mariappan, S., Devi, N. R., & Ananth, D. A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.883839 · Cited by 101 · see citing works
Dioscin: A review on pharmacological properties and therapeutic values
Bandopadhyay, S., Anand, U., Gadekar, V. S., Jha, N. K., Gupta, P. K., Behl, T., Kumar, M., CHAUHAN, R., Shekhawat, M. S., & Dey, A. (2021) · BioFactors · doi:10.1002/biof.1815 · Cited by 79 · see citing works
Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms
Ahmed, S., Ahmed, M. Z., Rafique, S., Almasoudi, S. E., Shah, M., Jalil, N. A. C., & Ojha, S. C. (2023) · BioMed Research International · doi:10.1155/2023/5250040 · Cited by 75 · see citing works
Combating Drug-Resistant Bacteria Using Photothermally Active Nanomaterials: A Perspective Review
Kaur, K., Reddy, S. M. L., Barathe, P., Shriram, V., Anand, U., Proćków, J., & Kumar, V. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.747019 · Cited by 67 · see citing works
Molecular Modeling Strategies of Cancer Multidrug Resistance
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Liu, Y., Cai, D., Li, X., Wu, Q., Ding, P., Shen, L., Yang, J., Hu, G., Wu, J., & Zhang, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0270945 · Cited by 64 · see citing works
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Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate
Anand, U., Bandyopadhyay, A., Jha, N. K., de la Lastra, J. M. P., & Dey, A. (2022) · BioFactors · doi:10.1002/biof.1913 · Cited by 62 · see citing works
Antibacterial Activity and Antifungal Activity of Monomeric Alkaloids
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, R., Scrano, L., & Bufo, S. A. (2024) · Toxins · doi:10.3390/toxins16110489 · Cited by 61 · see citing works
Emerging Non-Traditional Approaches to Combat Antibiotic Resistance
Konwar, A. N., Hazarika, S. N., Bharadwaj, P., & Thakur, D. (2022) · Current Microbiology · doi:10.1007/s00284-022-03029-7 · Cited by 58 · see citing works
Contato, A. G., & Conte‐Júnior, C. A. (2025) · Nutrients · doi:10.3390/nu17081307 · Cited by 58 · see citing works
Dextran-Coated Iron Oxide Nanoparticles Loaded with Curcumin for Antimicrobial Therapies
Chircov, C., Ștefan, R.-E., Dolete, G., Andrei, A., Holban, A. M., Oprea, O., Vasile, B. Ş., Neacșu, I. A., & Tihăuan, B.-M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051057 · Cited by 56 · see citing works
Exploring the potential of phytochemicals and nanomaterial: A boon to antimicrobial treatment
Yadav, H., Mahalvar, A., Pradhan, M., Yadav, D. K., Sahu, K. K., & Yadav, R. (2023) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2023.100151 · Cited by 62 · see citing works
Pérez‐Flores, J. G., García‐Curiel, L., Pérez-Escalante, E., Contreras‐López, E., Aguilar-Lira, G. Y., Angel‐Jijón, C., González-Olivares, L. G., Santillán, E. S. B., Ocampo, I. O. S., Guerrero-Solano, J. A., et al. (2025) · Applied Sciences · doi:10.3390/app15073516 · Cited by 67 · see citing works
Nano‐biotechnology in tumour and cancerous disease: A perspective review
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Damyanova, T., Dimitrova, P. D., Borisova, D., Topouzova‐Hristova, T., Haladjova, E., & Paunova-Krasteva, T. S. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020162 · Cited by 54 · see citing works
Insights into antibiofilm mechanisms of phytochemicals: Prospects in the food industry
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Almuhanna, Y., Alshalani, A., AlSudais, H., Alanazi, F., Alissa, M., Asad, M., & Joseph, B. (2024) · Biology · doi:10.3390/biology13090676 · Cited by 40 · see citing works
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Patel, K. K., Panchal, D. R., Sakariya, B., Gevariya, M., Raiyani, R., Soni, R., & Goswami, D. (2024) · The Microbe · doi:10.1016/j.microb.2024.100224 · Cited by 33 · see citing works
Potential of plants-based alkaloids, terpenoids and flavonoids as antibacterial agents: An update
Das, A., & Ruhal, R. (2025) · Process Biochemistry · doi:10.1016/j.procbio.2025.01.003 · Cited by 34 · see citing works
Ghosh, S., Basu, S., Anbarasu, A., & Ramaiah, S. (2025) · Phytotherapy Research · doi:10.1002/ptr.8365 · Cited by 33 · see citing works
A critical review of novel antibiotic resistance prevention approaches with a focus on postbiotics
Ozma, M. A., Moaddab, S. R., Hosseini, H., Khodadadi, E., Ghotaslou, R., Asgharzadeh, M., Abbasi, A., Kamounah, F. S., Maleki, L. A., Ganbarov, K., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2214818 · Cited by 31 · see citing works
Bhowmik, P., Modi, B., Roy, P., & Chowdhury, A. (2023) · Osong Public Health and Research Perspectives · doi:10.24171/j.phrp.2022.0323 · Cited by 29 · see citing works
Phage Therapy: Clinical Applications, Efficacy, and Implementation Hurdles
Fowoyo, P. T. (2024) · The Open Microbiology Journal · doi:10.2174/0118742858281566231221045303 · Cited by 29 · see citing works
Raikwar, G., Kumar, D., Mohan, S., & Dahiya, P. (2024) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2024.103384 · Cited by 31 · see citing works
Murugan, R., Subramaniyan, S., Priya, S., Ragavendran, C., Arasu, M. V., Al-Dhabi, N. A., Choi, K. C., Guru, A., & Arockiaraj, J. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106578 · Cited by 29 · see citing works
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Mechanism of antibacterial phytoconstituents: an updated review
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Therapeutic potential and industrial applications of Terminalia arjuna bark
Kumar, V., Sharma, N., Saini, R., Mall, S., Zengin, G., Sourirajan, A., Khosla, P. K., Dev, K., & El‐Shazly, M. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116352 · Cited by 26 · see citing works
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Antibiotic potentiators as a promising strategy for combating antibiotic resistance
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Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review
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Facing Resistant Bacteria with Plant Essential Oils: Reviewing the Oregano Case
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Functional, Antioxidant, Antibacterial, and Antifungal Activity of Edible Flowers
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Antimicrobial Screening and Fungicidal Properties of Eucalýptus globulus Ultrasonic Extracts
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Combating Antimicrobial Resistance: A paradigm shift from general to precision medicine
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Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds
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Bacterial drug resistance towards natural products
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Essential Oil Compounds in Combination with Conventional Antibiotics for Dermatology
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Advancements in Green Nanoparticle Technology: Focusing on the Treatment of Clinical Phytopathogens
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Antimicrobial Compounds from Food Waste in Cosmetics
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Phytotherapy in Diabetic Foot Ulcers: A Promising Strategy for Effective Wound Healing
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Importance of Oxidative Stress and Antioxidant System in Health and Disease
Sabuncuoğlu, S., & Yalçınkaya, A. S. (2022) · Biochemistry · doi:10.5772/intechopen.100949 · Cited by 16 · see citing works
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Analysis of Gut Microbial Communities and Resistance Genes in Pigs and Chickens in Central China
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Avian Pathogenic Escherichia coli: Advances in Pathogenesis, Diagnosis, and Control
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Delving into Agri-Food Waste Composition for Antibacterial Phytochemicals
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Fungal endophytes and their secondary metabolites for crop protection
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Anticancer potential of oroxylin A: from mechanistic insight to synergistic perspectives
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Sharma, L., & Bisht, G. S. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128248959231102114334 · Cited by 12 · see citing works
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Bioactive Composition of Tropical Flowers and Their Antioxidant and Antimicrobial Properties
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- Authors
- Khare, T., Anand, U., Dey, A., Assaraf, Y. G., Chen, Z.-S., Liu, Z., & Kumar, V.
- Affiliations
- Savitribai Phule Pune University (IN)
- Ben-Gurion University of the Negev (IL)
- Presidency University (IN)
- Technion – Israel Institute of Technology (IL)
- St. John's University (US)
- Weifang Medical University (CN)
- Corresponding author
- Chen, Zhe-Sheng
- Liu, Zhijun
- Kumar, Vinay
- Venue
- Frontiers in Pharmacology
- Publisher
- Frontiers Media SA
- Published
- 2021-07-21
- Volume
- 12
- Pages
- 720726-720726
- ISSN
- 1663-9812 (ISSN-L)
- PMC
- PMC8334005
- OpenAlex
- W3187946032
- Cited by
- 281
- References
- 198
- Citations by year
- 2026: 43 · 2025: 80 · 2024: 66 · 2023: 50 · 2022: 33 · 2021: 8
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Pharmacology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Shandong Province
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- phytochemicals, antibiotic resistance, multidrug-resistant pathogens, plant secondary metabolites, alkaloids, phenols, coumarins, terpenes, efflux pumps, biofilm, membrane proteins
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