Cited by 281Essential Oils and Antimicrobial ActivityAntibiotic Resistance in BacteriaAntimicrobial agents and applications

Exploring phytochemicals for combating antibiotic resistance in microbial pathogens

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Khare, Tushar, Anand, Uttpal, Dey, Abhijit, Assaraf, Yehuda G., Chen, Zhe-Sheng, Liu, Zhijun, Kumar, Vinay·2021·Frontiers in Pharmacology

Abstract

Antibiotic resistance or microbial drug resistance is emerging as a serious threat to human healthcare globally, and the multidrug-resistant (MDR) strains are imposing major hurdles to the progression of drug discovery programs. Newer antibiotic-resistance mechanisms in microbes contribute to the inefficacy of the existing drugs along with the prolonged illness and escalating expenditures. The injudicious usage of the conventional and commonly available antibiotics in human health, hygiene, veterinary and agricultural practices is proving to be a major driver for evolution, persistence and spread of antibiotic-resistance at a frightening rate. The drying pipeline of new and potent antibiotics is adding to the severity. Therefore, novel and effective new drugs and innovative therapies to treat MDR infections are urgently needed. Apart from the different natural and synthetic drugs being tested, plant secondary metabolites or phytochemicals are proving efficient in combating the drug-resistant strains. Various phytochemicals from classes including alkaloids, phenols, coumarins, terpenes have been successfully demonstrated their inhibitory potential against the drug-resistant pathogens. Several phytochemicals have proved effective against the molecular determinants responsible for attaining the drug resistance in pathogens like membrane proteins, biofilms, efflux pumps and bacterial cell communications. However, translational success rate needs to be improved, but the trends are encouraging. This review highlights current knowledge and developments associated challenges and future prospects for the successful application of phytochemicals in combating antibiotic resistance and the resistant microbial pathogens.

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  1. Robbers J. Speedie M. Tyler V. (1996). “ Chapter 9: Alkaloids,” in Pharmacognosy And Pharmacobiotechnology”. Editors Robbers J. Speedie M. Tyler (London, UK: V. (Williams & Wilkins), 144– 185.

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Authors
Khare, T., Anand, U., Dey, A., Assaraf, Y. G., Chen, Z.-S., Liu, Z., & Kumar, V.
Affiliations
  • Savitribai Phule Pune University (IN)
  • Ben-Gurion University of the Negev (IL)
  • Presidency University (IN)
  • Technion – Israel Institute of Technology (IL)
  • St. John's University (US)
  • Weifang Medical University (CN)
Corresponding author
  • Chen, Zhe-Sheng
  • Liu, Zhijun
  • Kumar, Vinay
Venue
Frontiers in Pharmacology
Published
2021-07-21
Volume
12
Pages
720726-720726
ISSN
1663-9812 (ISSN-L)
OpenAlex
W3187946032
Cited by
281
References
198
Citations by year
2026: 43 · 2025: 80 · 2024: 66 · 2023: 50 · 2022: 33 · 2021: 8
FWCI
3.58
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Natural Science Foundation of Shandong Province
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Keywords
phytochemicals, antibiotic resistance, multidrug-resistant pathogens, plant secondary metabolites, alkaloids, phenols, coumarins, terpenes, efflux pumps, biofilm, membrane proteins

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