The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
G484S Amino Acid Substitution in Lanosterol 14-α Demethylase ( ERG11 ) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate
Open accessAbstract
Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-α lanosterol demethylase gene ( ERG11 ) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.
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“For C. neoformans, a limited number of ERG11 mutations have been described in azole-resistant clinical isolates16.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [16]
Citations
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Metadata
- Authors
- Rodero, L., Mellado, E., Rodriguez, A. C., Salve, A., Guelfand, L., Cahn, P., Cuenca-Estrella, M., Davel, G., & Rodriguez-Tudela, J. L.
- Affiliations
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- Instituto de Salud Carlos III (ES)
- Hospital Fernández (AR)
- Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2003-11
- Volume
- 47
- Issue
- 11
- Pages
- 3653-3656
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC253790
- OpenAlex
- W2142427146
- Cited by
- 139
- References
- 15
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 3 · 2017: 10 · 2016: 10 · 2015: 5 · 2014: 14 · 2013: 6 · 2012: 5
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Keywords
- Cryptococcus neoformans, fluconazole resistance, ERG11, lanosterol 14α-demethylase, point mutations, recurrent meningitis, AIDS, antifungal resistance, clinical isolates
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Amino Acid Sequence, Antifungal Agents, Cloning, Molecular, Cryptococcus neoformans, Cytochrome P-450 Enzyme System, Genotype, Humans, Male, Microbial Sensitivity Tests, Molecular Sequence Data, Oxidoreductases, Plasmids, Recurrence, Fluconazole, Meningitis, Cryptococcal, Point Mutation, Amino Acid Substitution, Drug Resistance, Fungal, Sterol 14-Demethylase
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