Cited by 139Antifungal resistance and susceptibilityFungal Infections and StudiesFungal Plant Pathogen Control

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G484S Amino Acid Substitution in Lanosterol 14-α Demethylase ( ERG11 ) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate

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Rodero, Laura, Mellado, Emilia, Rodriguez, A. Carolina, Salve, Angela, Guelfand, Liliana, Cahn, Pedro, Cuenca-Estrella, Manuel, Davel, Graciela, Rodriguez-Tudela, Juan L.·2003·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.47.11.3653-3656.2003PMC PMC253790

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Abstract

Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-α lanosterol demethylase gene ( ERG11 ) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.

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Authors: Rodero, L., Mellado, E., Rodriguez, A. C., Salve, A., Guelfand, L., Cahn, P., Cuenca-Estrella, M., Davel, G., & Rodriguez-Tudela, J. L.
Affiliations: Administración Nacional de Laboratorios e Institutos de Salud (AR)
Instituto de Salud Carlos III (ES)
Hospital Fernández (AR)
Unidad de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain
ORCID: Mellado, Emilia
Guelfand, Liliana
Cahn, Pedro
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2003-11
Volume: 47
Issue: 11
Pages: 3653-3656
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.47.11.3653-3656.2003
PMC: PMC253790
OpenAlex: W2142427146
Cited by: 139
References: 15
Citations by year: 2026: 5 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 4 · 2020: 7 · 2019: 12 · 2018: 3 · 2017: 10 · 2016: 10 · 2015: 5 · 2014: 14 · 2013: 6 · 2012: 5
FWCI: 1.17
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Keywords: Cryptococcus neoformans, fluconazole resistance, ERG11, lanosterol 14α-demethylase, point mutations, recurrent meningitis, AIDS, antifungal resistance, clinical isolates
MeSH terms: Acquired Immunodeficiency Syndrome, Adult, Amino Acid Sequence, Antifungal Agents, Cloning, Molecular, Cryptococcus neoformans, Cytochrome P-450 Enzyme System, Genotype, Humans, Male, Microbial Sensitivity Tests, Molecular Sequence Data, Oxidoreductases, Plasmids, Recurrence, Fluconazole, Meningitis, Cryptococcal, Point Mutation, Amino Acid Substitution, Drug Resistance, Fungal, Sterol 14-Demethylase

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G484S Amino Acid Substitution in Lanosterol 14-α Demethylase ( ERG11 ) Is Related to Fluconazole Resistance in a Recurrent Cryptococcus neoformans Clinical Isolate

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