Cited by 165Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

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AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis

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Visalli, Melissa A., Murphy, Ellen, Projan, Steven J., Bradford, Patricia A.·2003·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.47.2.665-669.2003PMC PMC151746

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Abstract

Tigecycline has good broad-spectrum activity against many gram-positive and gram-negative pathogens with the notable exception of the Proteeae . A study was performed to identify the mechanism responsible for the reduced susceptibility to tigecycline in Proteus mirabilis . Two independent transposon insertion mutants of P. mirabilis that had 16-fold-increased susceptibility to tigecycline were mapped to the acrB gene homolog of the Escherichia coli AcrRAB efflux system. Wild-type levels of decreased susceptibility to tigecycline were restored to the insertion mutants by complementation with a clone containing a PCR-derived fragment from the parental wild-type acrRAB efflux gene cluster. The AcrAB transport system appears to be associated with the intrinsic reduced susceptibility to tigecycline in P. mirabilis .

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically
Ferraro, M. J. (2000) · Cited by 16,875
National Committee for Clinical Laboratory Standards
Bruck, E. (1980) · PEDIATRICS · doi:10.1542/peds.65.1.187 · Cited by 14,736
REPLICA PLATING AND INDIRECT SELECTION OF BACTERIAL MUTANTS
Lederberg, J., & Lederberg, E. M. (1952) · Journal of Bacteriology · doi:10.1128/jb.63.3.399-406.1952 · Cited by 1,355
Multidrug efflux pumps of gram-negative bacteria
Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.20.5853-5859.1996 · Cited by 1,095
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
Okusu, H., Ma, D., & Nikaido, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.1.306-308.1996 · Cited by 818
In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9- t -Butylglycylamido Derivative of Minocycline (GAR-936)
Petersen, P. J., Jacobus, N. V., Weiss, W. J., Sum, P., & TESTA, R. T. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.4.738 · Cited by 413
Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli
Fralick, J. A. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5803-5805.1996 · Cited by 409
Antibiotic efflux pumps
Françoise Van Bambeke, A., Balzi, E., & Tulkens, P. M. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00291-4 · Cited by 404
Overexpression ofmarA, soxS, oracrABproduces resistance to triclosan in laboratory and clinical strains ofEscherichia coli
McMurry, L. M., Oethinger, M. D., & Levy, S. B. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb13905.x · Cited by 346

Show all 25 references

Research works printed but not linked: 1

Sambrook J. E. E. F. Fritsch and T. Maniatis. 1989. Molecular cloning: a laboratory manual 2nd ed. Cold Spring Harbor Laboratory Press Cold Spring Harbor N.Y.

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Curcio, D., Barcelona, L., Cornistein, W., Bantar, C., Barcán, L., Bonvehí, P., Reina, R., Bergallo, C., Biondi, H., Calderón, J., et al. (2009) · Clinical Medicine Therapeutics · doi:10.4137/cmt.s3312 · Cited by 1
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Cada, D. J., Levien, T. L., & Baker, D. E. (2005) · Hospital Pharmacy · doi:10.1177/001857870504001009 · Cited by 1
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Villa, L., Feudi, C., Fortini, D., García-Fernández, A., & Carattoli, A. (2013)
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State, E., & Ogun, O. O. (2007)
Understanding Bacterial Resistance and Dissemination: The Impact of Biocide Priming
Adkin, O. P. (2020) · DMU Open Research Archive (De Montfort University)
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Shah, R. A. (2021) · Updates in clinical dermatology · doi:10.1007/978-3-030-68321-4_1
II-H-25 重度脳性麻痺における脊柱側彎変形に対する軟性コルセットの治療効果
沖, 高., 服部, 義., 矢崎, 進., & 伊藤, 弘. (2000) · リハビリテーション医学 : 日本リハビリテーション医学会誌
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Authors: Visalli, M. A., Murphy, E., Projan, S. J., & Bradford, P. A.
Affiliations: Wyeth (US)
Corresponding author: Visalli, Melissa A.
ORCID: Bradford, Patricia A.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2003-02
Volume: 47
Issue: 2
Pages: 665-669
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.47.2.665-669.2003
PMC: PMC151746
OpenAlex: W1976898407
Cited by: 165
References: 25
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 6 · 2012: 4
FWCI: 7.83
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: tigecycline, Proteus mirabilis, AcrAB efflux pump, multidrug efflux, transposon mutants, complementation, tetracycline resistance
MeSH terms: Tigecycline, Carrier Proteins, DNA Transposable Elements, Membrane Proteins, Minocycline, Proteus mirabilis, Drug Resistance, Bacterial, ATP-Binding Cassette, Sub-Family C Proteins, Escherichia coli Proteins

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AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis

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