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Cited by 165Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

AcrAB Multidrug Efflux Pump Is Associated with Reduced Levels of Susceptibility to Tigecycline (GAR-936) in Proteus mirabilis

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Visalli, Melissa A., Murphy, Ellen, Projan, Steven J., Bradford, Patricia A.·2003·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.47.2.665-669.2003PMC PMC151746
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Abstract

Tigecycline has good broad-spectrum activity against many gram-positive and gram-negative pathogens with the notable exception of the Proteeae . A study was performed to identify the mechanism responsible for the reduced susceptibility to tigecycline in Proteus mirabilis . Two independent transposon insertion mutants of P. mirabilis that had 16-fold-increased susceptibility to tigecycline were mapped to the acrB gene homolog of the Escherichia coli AcrRAB efflux system. Wild-type levels of decreased susceptibility to tigecycline were restored to the insertion mutants by complementation with a clone containing a PCR-derived fragment from the parental wild-type acrRAB efflux gene cluster. The AcrAB transport system appears to be associated with the intrinsic reduced susceptibility to tigecycline in P. mirabilis .

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Crossref · 10.1128/aac.47.2.665-669.2003

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Research works printed but not linked: 1

  1. Sambrook J. E. E. F. Fritsch and T. Maniatis. 1989. Molecular cloning: a laboratory manual 2nd ed. Cold Spring Harbor Laboratory Press Cold Spring Harbor N.Y.

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Metadata

Authors
Visalli, M. A., Murphy, E., Projan, S. J., & Bradford, P. A.
Affiliations
Wyeth (US)
Corresponding author
Visalli, Melissa A.
ORCID
Bradford, Patricia A.
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2003-02
Volume
47
Issue
2
Pages
665-669
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.47.2.665-669.2003
PMC
PMC151746
OpenAlex
W1976898407
Cited by
165
References
25
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 6 · 2012: 4
FWCI
7.83
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
tigecycline, Proteus mirabilis, AcrAB efflux pump, multidrug efflux, transposon mutants, complementation, tetracycline resistance
MeSH terms
Tigecycline, Carrier Proteins, DNA Transposable Elements, Membrane Proteins, Minocycline, Proteus mirabilis, Drug Resistance, Bacterial, ATP-Binding Cassette, Sub-Family C Proteins, Escherichia coli Proteins

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