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Cited by 222Antifungal resistance and susceptibilityAntibiotic Resistance in BacteriaFungal Plant Pathogen Control

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Mechanism of Increased Fluconazole Resistance in Candida glabrata during Prophylaxis

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Bennett, John E., Izumikawa, Koichi, Marr, Kieren A.·2004·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.48.5.1773-1777.2004PMC PMC400565
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Abstract

Candida glabrata can become resistant to fluconazole, causing persistent colonization and invasive infection during prolonged exposure to the drug. To determine the mechanism of resistance in this setting, weekly oropharyngeal cultures for C. glabrata were obtained over a 2-year period from hematopoietic stem cell transplant recipients who were receiving fluconazole prophylaxis. In 20 patients from whom at least two isolates of the same karyotype were obtained more than two weeks apart, fluconazole MICs doubled every 31 days on average. The mechanism of fluconazole resistance in isolates from the 14 of the 20 patients studied in whom MICs changed at least fourfold was studied. Cellular resistance was accompanied by increased drug efflux as measured by decreased accumulation of fluconazole and rhodamine 6G and increased abundance of transcripts from two drug transporters, CgCDR1 and PDH1. The rapidity and regularity of the rising resistance indicated that C. glabrata is able to upregulate drug efflux without losing the ability to maintain colonization.

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  1. Ausubel F. M. R. Brent R. E. Kingston D. D. Moore J. G. Seidman J. A. Smith and K. Struhl. 1998. Current protocols in molecular biology. John Wiley & Sons Somerset N.J.

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Metadata

Authors
Bennett, J. E., Izumikawa, K., & Marr, K. A.
Affiliations
  • National Institutes of Health (US)
  • University of Washington (US)
ORCID
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2004-05
Volume
48
Issue
5
Pages
1773-1777
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.48.5.1773-1777.2004
PMC
PMC400565
OpenAlex
W2108027055
Cited by
217
References
20
Citations by year
2025: 4 · 2024: 5 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 10 · 2014: 15 · 2013: 17 · 2012: 11
FWCI
8.64
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08ai001571-02)
  • National Institute of Allergy and Infectious Diseases (AI01571)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Keywords
Candida glabrata, fluconazole resistance, antifungal prophylaxis, hematopoietic stem cell transplant recipients, drug efflux, oropharyngeal colonization, invasive candidiasis
MeSH terms
Antifungal Agents, Candidiasis, Fluorescent Dyes, Karyotyping, Rhodamines, Blotting, Northern, Fluconazole, Electrophoresis, Gel, Pulsed-Field, Reverse Transcriptase Polymerase Chain Reaction, Drug Resistance, Fungal, Drug Resistance, Multiple, Fungal, Candida glabrata

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