Development of Fluconazole Resistance in Candida albicans Causing Disseminated Infection in a Patient Undergoing Marrow Transplantation

Marr, Kieren A.; White, Theodore C.; van Burik, Jo‐Anne H.; Bowden, Raleigh A.

doi:10.1086/515553

Cited by 145Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

Development of Fluconazole Resistance in Candida albicans Causing Disseminated Infection in a Patient Undergoing Marrow Transplantation

Marr, Kieren A., White, Theodore C., van Burik, Jo‐Anne H., Bowden, Raleigh A.·1997·Clinical Infectious Diseases

DOI 10.1086/515553

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Abstract

Oral candidiasis due to azole-resistant Candida albicans is an increasing problem in patients with AIDS who received prolonged periods of fluconazole prophylaxis. Infection with C. albicans is also frequent in patients undergoing transplantation. However, azole resistance has not been appreciated as a major problem for these patients, presumably because they receive a relatively short duration of fluconazole prophylaxis. We describe a case of disseminated candidiasis due to fluconazole-resistant C. albicans in a patient following marrow transplantation. Restriction fragment length polymorphism analysis with use of the C. albicans strain-specific Ca3 probe was performed on sequential isolates. Identical banding patterns were obtained, thereby confirming that a fluconazole-susceptible endogenous C. albicans acquired azole resistance during a brief exposure to the drug and subsequently caused disseminated infection. This observation raises questions regarding the incidence, significance, and mechanism of azole resistance in fungi causing infection in this population.

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Azole resistance for C. albicans is well described among HIV-infected individuals with recurrent oropharyngeal candidiasis.
“However, azole resistance for this species is now well described among HIV-infected individuals with recurrent oropharyngeal candidiasis and is also reported sporadically in critically ill adults with invasive candidiasis [25] or in healthy adults [26].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [25]
Azole resistance for C. albicans is reported sporadically in critically ill adults with invasive candidiasis.
“However, azole resistance for this species is now well described among HIV-infected individuals with recurrent oropharyngeal candidiasis and is also reported sporadically in critically ill adults with invasive candidiasis [25] or in healthy adults [26].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [25]

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PUTATIVE VIRULENCE FACTORS OF CANDIDA ALBICANS
Cutler, J. E. (1991) · Annual Review of Microbiology · doi:10.1146/annurev.mi.45.100191.001155 · Cited by 632 · see citing works

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Fluconazole-resistant C. albicans has been reported to cause oropharyngeal candidiasis in patients with AIDS world- 1. Sable CA, Donowitz GR. Infections in bone marrow transplant recipients. wide [5, 11, 12]. In these cases, resistance develops when Clin Infect Dis 1994; 18:273 -84.
Nolte FS, Parkinson T, Falconer DJ, et al. Isolation and characterization fluconazole [5, 11, 13]. of fluconazole-and amphotericin B-resistant Candida albicans from blood of two patients with leukemia. Antimicrob Agents Chemother It is not surprising that azole resistance has now become 1997; 41:196 -9.
Rex JH, Rinaldi MG, Pfaller MA. Resistance of Candida species to fluco- cause of the short duration of drug exposure in these patients, nazole. Antimicrob Agents Chemother 1995;39:1-8.
Sadhu C, McEachern MJ, Rustchenko-Bulgac EP, Schmid J, Soll DR, emerged because of the selection pressure of fluconazole. Un- Hicks JB. Telomeric and dispersed repeat sequences in Candida yeasts fortunately, colonizing strains were not available for analysis and their use in strain identification. J Bacteriol 1991; 173:842 -50. in their study. In our study, one susceptible strain became
Hoffman CS, Winston F. A ten-minute DNA preparation from yeast effi- resistant after only 23 days of fluconazole administration. ciently releases autonomous plasmids for transformation of Escherichia coli. Gene 1987; 57:267 -72.
nizing strain of C. albicans present in the rectum was also 9. Schmid J, Tay YP, Wan L, et al. Evidence for nosocomial transmission present in the respiratory tract but did not become resistant to of Candida albicans obtained by Ca3 fingerprinting. J Clin Microbiol 1995; 33:1223 -30. fluconazole because it was protected from exposure to the same 10. Stevens DA, Odds FC, Scherer S. Application of DNA typing methods to quantities of drug. Alternatively, it is possible that both suscep- Candida albicans epidemiology and correlations with phenotype. Rev tible and resistant isolates of the same strain colonized this Infect Dis 1990; 12:258 -66.
patient and that fluconazole had a selection effect, thus increas- 11. Pfaller MA, Rhine-Chalberg J, Redding SW, et al. Variations in flucona- ing the likelihood of recovering a resistant isolate during ther- zole susceptibility and electrophoretic karyotype among oral isolates of Candida albicans from patients with AIDS and oral candidiasis. J Clin apy. Finally, the isolate may have lost resistance after flucona- Microbiol 1994; 32:59 -64. zole therapy was discontinued. We are currently studying the

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Self-citation
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Doyle, T. C., Nawotka, K. A., Purchio, A. F., Akin, A. R., Francis, K. P., & Contag, P. R. (2006) · Microbial Pathogenesis · doi:10.1016/j.micpath.2005.11.002 · Cited by 36 · see citing works
Efficacy of PLD-118, a Novel Inhibitor of Candida Isoleucyl-tRNA Synthetase, against Experimental Oropharyngeal and Esophageal Candidiasis Caused by Fluconazole-Resistant C. albicans
Petraitis, V., Petraitienė, R., Kelaher, A. M., Sarafandi, A. A., Sein, T., Mickiene, D., Bacher, J. D., Groll, A. H., & Walsh, T. J. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.10.3959-3967.2004 · Cited by 36 · see citing works
Periodontal treatment considerations for cell transplant and organ transplant patients
Vasanthan, A., & Dallal, N. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00198.x · Cited by 35 · see citing works
A Novel Mechanism of Fluconazole Resistance Associated with Fluconazole Sequestration in Candida albicans Isolates from a Myelofibrosis Patient
Maebashi, K., Kudoh, M., Nishiyama, Y., Makimura, K., Uchida, K., Mori, T., & Yamaguchi, H. (2002) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2002.tb02702.x · Cited by 33 · see citing works
In Vitro Interaction of Posaconazole and Caspofungin against Clinical Isolates of Candida glabrata
Oliveira, E. R., Fothergill, A. W., Kirkpatrick, W. R., Coco, B. J., Patterson, T. F., & Redding, S. W. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.8.3544-3545.2005 · Cited by 31 · see citing works
Voriconazole and fluconazole susceptibility of Candida isolates
PELLETIER, R., LORANGER, L., MARCOTTE, H., & Carolis, E. D. (2002) · Journal of Medical Microbiology · doi:10.1099/0022-1317-51-6-479 · Cited by 31 · see citing works
Population dynamics and the evolution of antifungal drug resistance in Candida albicans
Huang, M., & Kao, K. C. (2012) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2012.02587.x · Cited by 30 · see citing works
cDNA microarray analysis of differential gene expression and regulation in clinically drug-resistant isolates of Candida albicans from bone marrow transplanted patients
Xu, Z. Q., Zhang, L., Zhang, J., Cao, Y., Yu, Y.-Y., Wang, D., Ying, K., Chen, W., & Jiang, Y. (2006) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2006.03.004 · Cited by 30 · see citing works
Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens
Sanglard, D. (2003) · Mycologist · doi:10.1017/s0269915x03002076 · Cited by 29 · see citing works
Emerging fungal pathogens, drug resistance and the role of lipid formulations of amphotericin b in the treatment of fungal infections in cancer patients: A review
Viscoli, C., & Castagnola, E. (1999) · International Journal of Infectious Diseases · doi:10.1016/s1201-9712(99)90019-x · Cited by 29 · see citing works
Characterization of Mechanisms of Fluconazole Resistance in a Candida albicans Isolate from a Japanese Patient with Chronic Mucocutaneous Candidiasis
Kamai, Y., Maebashi, K., Kudoh, M., Makimura, K., Naka, W., Uchida, K., & Yamaguchi, H. (2004) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2004.tb03623.x · Cited by 27 · see citing works
Micafungin activity against Candida albicans with diverse azole resistance phenotypes
Richards, T. S., Oliver, B. G. G., & White, T. C. (2008) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkn156 · Cited by 25 · see citing works
Self-citation
Support for the EUCAST and revised CLSI fluconazole clinical breakpoints by Sensititre(R) YeastOne(R) for Candida albicans: a prospective observational cohort study
van Hal, S. J., Chen, S. C. A., Sorrell, T. C., Ellis, D. H., Slavin, M. A., & Marriott, D. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku124 · Cited by 25 · see citing works
Differential Response of Candida Species Morphologies and Isolates to Fluconazole and Boric Acid
Salama, O. E., & Gerstein, A. C. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02406-21 · Cited by 24 · see citing works
A first-in-class inhibitor of Hsp110 molecular chaperones of pathogenic fungi
Hu, L., Sun, C., Kidd, J. M., Han, J., Fang, X., Li, H., Liu, Q., May, A. E., Li, Q., Zhou, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38220-2 · Cited by 24 · see citing works
Prevalence of Candida species in different hospital wards and their susceptibility to antifungal agents: results of a three year survey
Fadda, M. E., Podda, G., Pisano, M. B., Deplano, M., & Cosentino, S. (2015) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2008.49.2.119 · Cited by 23 · see citing works
Mannose-Binding Quinone Glycoside, MBQ: Potential Utility and Action Mechanism
Igarashi, Y., & OKI, T. (2004) · Advances in applied microbiology · doi:10.1016/s0065-2164(04)54006-6 · Cited by 23 · see citing works
Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States
Smith, A. C., & Hickman, M. A. (2020) · mSphere · doi:10.1128/msphere.00433-20 · Cited by 22 · see citing works
Will resistance in fungi emerge on a scale similar to that seen in bacteria?
Hof, H. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0451-9 · Cited by 22 · see citing works
In vitro activity of five antifungal drugs against Candida albicans isolates in Sari, Iran
Afsarian, S. M. H. (2016) · Current Medical Mycology · doi:10.18869/acadpub.cmm.2.2.8 · Cited by 22 · see citing works
Acute and sub-acute toxicity study of the root extracts of Fagaropsis hildebrandtii in mice and evaluation of their antimicrobial effects
Muia, B. M., Mbaria, J. M., Kanja, L. W., Gitahi, N., Okumu, P. O., & Okumu, M. O. (2019) · F1000Research · doi:10.12688/f1000research.19915.1 · Cited by 22 · see citing works
In vitro antifungal susceptibility testing of Candida blood isolates and evaluation of the E-test method.
Lu, J., Lee, S.-Y., & Chiueh, T. (2004) · PubMed · Cited by 19 · see citing works
Risk of Infections in Adult Patients with Haematological Malignancies
Nørgaard, M. (2012) · The Open Infectious Diseases Journal · doi:10.2174/1874279301206010046 · Cited by 18 · see citing works
Antifungal Susceptibility Testing
Fothergill, A. W., Rinaldi, M. G., & Sutton, D. A. (2006) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2006.06.008 · Cited by 18 · see citing works
Candida
Dignani, M. C., Solomkin, J. S., & Anaissie, E. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-5680-5.00008-6 · Cited by 18 · see citing works
Antifungal prophylaxis among allogeneic hematopoietic stem cell transplant recipients: current issues and new agents
Strasfeld, L. M., & Weinstock, D. M. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.3.457 · Cited by 16 · see citing works
Breakthrough fungemia caused by fluconazole-resistant Candida albicans with decreased susceptibility to voriconazole in patients with hematologic malignancies.
Myoken, Y., Kyo, T., Sugata, T., Murayama, S. Y., & Mikami, Y. (2006) · PubMed · Cited by 16 · see citing works
Host Defense Mechanisms Induce Genome Instability Leading to Rapid Evolution in an Opportunistic Fungal Pathogen
Smith, A. C., Morran, L. T., & Hickman, M. A. (2021) · Infection and Immunity · doi:10.1128/iai.00328-21 · Cited by 15 · see citing works

Inducible Azole Resistance Associated with a Heterogeneous Phenotype in Candida albicans
Marr, K. A., Lyons, C. N., Ha, K. C., Rustad, T. R., & White, T. C. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.1.52-59.2001 · Cited by 106 · see citing works
Self-citation
Candidemia in Allogeneic Blood and Marrow Transplant Recipients: Evolution of Risk Factors after the Adoption of Prophylactic Fluconazole
Marr, K. A., Seidel, K., White, T. C., & Bowden, R. A. (2000) · The Journal of Infectious Diseases · doi:10.1086/315193 · Cited by 493 · see citing works
Self-citation
Azole-Resistant Candida albicans: Report of Two Cases of Resistance to Fluconazole and Review
White, A., & Goetz, M. B. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.4.687 · Cited by 64 · see citing works
Development of simultaneous resistance to fluconazole in Candida albicans and Candida dubliniensis in a patient with AIDS
Ruhnke, M. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.2.291 · Cited by 63 · see citing works
Rapid, Transient Fluconazole Resistance in Candida albicans Is Associated with Increased mRNA Levels of CDR
Marr, K. A., Lyons, C. N., Rustad, T., Bowden, R. A., & White, T. C. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.10.2584 · Cited by 166 · see citing works
Self-citation

Authors: Marr, K. A., White, T. C., van Burik, J. H., & Bowden, R. A.
Affiliations: Center for Infectious Disease Research (US)
Corresponding author: Marr, Kieren A.
ORCID: Marr, Kieren A.
White, Theodore C.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 1997-10
Volume: 25
Issue: 4
Pages: 908-910
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/515553
OpenAlex: W2139596056
Cited by: 145
References: 1
Citations by year: 2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 6
FWCI: 5.85
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (2T32 A107044-21)
National Institute of Dental and Craniofacial Research (R01DE011367, R01 DE-11367)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: fluconazole resistance, Candida albicans, systemic candidiasis, bone marrow transplantation, azole resistance, oral candidiasis, fluconazole prophylaxis, restriction fragment length polymorphism, antifungal resistance
MeSH terms: Adult, Antifungal Agents, Candida albicans, Candidiasis, Oral, Drug Resistance, Microbial, Humans, Lymphoma, Non-Hodgkin, Male, Fluconazole, Bone Marrow Transplantation, Immunocompromised Host, Antibiotic Prophylaxis

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Development of Fluconazole Resistance in Candida albicans Causing Disseminated Infection in a Patient Undergoing Marrow Transplantation

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