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Efficacy of Trimethoprim and Sulfamethoxazole in the Prevention and Treatment of Pneumocystis carinii Pneumonitis
Open accessAbstract
A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats. Although all of 15 untreated rats died with P. carinii pneumonitis, none of 15 given trimethoprim-sulfamethoxazole prophylactically acquired the infection. After P. carinii pneumonitis was established, 9 of 14 rats recovered after treatment with trimethoprim-sulfamethoxazole compared with only 2 of 14 treated with pentamidine isethionate. Rifampin and clindamycin, separately or in combination with pentamidine, were ineffective in the prevention and treatment of P. carinii infection.
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Citations
Cited by
Fischl, M. A. (1988) · JAMA · doi:10.1001/jama.259.8.1185 · Cited by 422
Successful Intermittent Chemoprophylaxis for Pneumocystis carinii Pneumonitis
Hughes, W. T., Rivera, G. K., Schell, M. J., Thornton, D., & Lott, L. (1987) · New England Journal of Medicine · doi:10.1056/nejm198706253162604 · Cited by 398
Self-citationWalzer, P. D., Foy, J., Steele, P., Kim, C. K., White, M., Klein, R. S., Otter, B. A., & Allegra, C. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.9.1935 · Cited by 67
Metadata
- Authors
- Hughes, W. T., McNabb, P. C., Makres, T. D., & Feldman, S.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1974-03
- Volume
- 5
- Issue
- 3
- Pages
- 289-293
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2086987280
- Cited by
- 217
- References
- 0
- FWCI
- 8.72
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Efficacy of Trimethoprim and Sulfamethoxazole in the Prevention and Treatment of Pneumocystis carinii Pneumonitis. https://app.cochat.ai/papers/10.1128/aac.5.3.289
- The paper
- Hughes, W. T., McNabb, P. C., Makres, T. D., & Feldman, S. (1974). Efficacy of Trimethoprim and Sulfamethoxazole in the Prevention and Treatment of Pneumocystis carinii Pneumonitis. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.5.3.289
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
