The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Successful Intermittent Chemoprophylaxis for Pneumocystis carinii Pneumonitis
Abstract
We conducted a prospective, randomized clinical trial over a two-year period in patients with acute lymphocytic leukemia to assess the effectiveness of trimethoprim-sulfamethoxazole given on three consecutive days each week as compared with daily in the prevention of Pneumocystis carinii pneumonitis. P. carinii pneumonitis did not develop in any of 92 patients receiving the drug daily (30,602 patient-days) or in any of 74 who received it three consecutive days a week (27,329 patient-days), whereas the incidence of the infection expected without prophylaxis is 21 percent. One patient, excluded from both groups because of an adverse reaction to sulfonamides in the past, acquired P. carinii pneumonitis. Especially noteworthy was a difference in the occurrence of systemic mycoses, with 10 cases in the daily-treatment group and only 1 case in the three-days-a-week group (P = 0.024). No differences were observed in the rates of other infections or adverse effects associated with the drug. We conclude that trimethoprim-sulfamethoxazole is as effective given three days a week as it is given daily in the prevention of P. carinii pneumonitis and that the intermittent schedule has the advantages of less frequent fungal infections and lower cost. Intermittent chemoprophylaxis may be especially beneficial to certain patients who are unable to tolerate the daily doses.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
GORDIN, F. M., SIMON, G. L., WOFSY, C. B., & MILLS, J. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-4-495 · Cited by 704
Successful Chemoprophylaxis for Pneumocystis carinii Pneumonitis
Hughes, W. T., Kuhn, S., Chaudhary, S., Feldman, S., Verzosa, M., Aur, R. J. A., Pratt, C., & George, S. L. (1977) · New England Journal of Medicine · doi:10.1056/nejm197712292972602 · Cited by 690
Self-citationJaffe, H., Ammann, A., Abrams, D., Lewis, B., & Golden, J. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90627-x · Cited by 222
Hughes, W. T., McNabb, P. C., Makres, T. D., & Feldman, S. (1974) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.5.3.289 · Cited by 217
Self-citationAdverse Reactions to Trimethoprim-Sulfamethoxazole in Hospitalized Patients
Jick, H. (1982) · Clinical Infectious Diseases · doi:10.1093/clinids/4.2.426 · Cited by 192
Pizzo, P. A., Robichaud, K. J., Edwards, B. K., Schumaker, C., Kramer, B. S., & Johnson, A. (1983) · The Journal of Pediatrics · doi:10.1016/s0022-3476(83)80310-2 · Cited by 166
Gualtieri, R., Donowitz, G. R., Kaiser, D. L., Hess, C. E., & Sande, M. A. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)90785-4 · Cited by 106
The Treatment of Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome
Small, C. B. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.1985.00360050081015 · Cited by 105
Kluge, R. M., Spaulding, D. M., & Spain, A. J. (1978) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.13.6.975 · Cited by 66
Limited effect of trimethoprim-sulfamethoxazole prophylaxis on Pneumocystis carinii
Hughes, W. T. (1979) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.16.3.333 · Cited by 59
Self-citation
Cited by
2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer
Hughes, W. T., Armstrong, D., Bodey, G. P., Bow, E. J., Brown, A. E., Calandra, T., Feld, R., Pizzo, P. A., Rolston, K. V. I., Shenep, J. L., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/339215 · Cited by 1,964
Self-citationSpecial Issue: KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients
Eckardt, K.-U., Kasiske, B. L., & Zeier, M. G. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02834.x · Cited by 1,499
Pui, C.-H., & Evans, W. E. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808273390907 · Cited by 832
Randomisation and baseline comparisons in clinical trials
Altman, D. G., & Doré, C. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)90014-v · Cited by 508
Fischl, M. A. (1988) · JAMA · doi:10.1001/jama.259.8.1185 · Cited by 422
Metadata
- Authors
- Hughes, W. T., Rivera, G. K., Schell, M. J., Thornton, D., & Lott, L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1987-06-25
- Volume
- 316
- Issue
- 26
- Pages
- 1627-1632
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2324671927
- Cited by
- 398
- References
- 12
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Successful Intermittent Chemoprophylaxis for Pneumocystis carinii Pneumonitis. https://app.cochat.ai/papers/10.1056/nejm198706253162604
- The paper
- Hughes, W. T., Rivera, G. K., Schell, M. J., Thornton, D., & Lott, L. (1987). Successful Intermittent Chemoprophylaxis for Pneumocystis carinii Pneumonitis. New England Journal of Medicine. https://doi.org/10.1056/nejm198706253162604
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
