Antifungal Activity of C-27 Steroidal Saponins
Abstract
As part of our search for new antifungal agents from natural resources, 22 C-27 steroidal saponins and 6 steroidal sapogenins isolated from several monocotyledonous plants were tested for their antifungal activity against the opportunistic pathogens Candida albicans , Candida glabrata , Candida krusei , Cryptococcus neoformans , and Aspergillus fumigatus . The results showed that the antifungal activity of the steroidal saponins was associated with their aglycone moieties and the number and structure of monosaccharide units in their sugar chains. Within the 10 active saponins, four tigogenin saponins (compounds 1 to 4) with a sugar moiety of four or five monosaccharide units exhibited significant activity against C. neoformans and A. fumigatus , comparable to the positive control amphotericin B. The antifungal potency of these compounds was not associated with cytotoxicity to mammalian cells. This suggests that the C-27 steroidal saponins may be considered potential antifungal leads for further preclinical study.
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Steroidal saponins give protection to plants against fungi and other several pathogens.
“The steroidal saponins give protection to plants against fungi and other several pathogens (Sprag et al., 2004;Yang et al., 2006;Saniewska et al., 2005;Elisa et al., 2007).”
From Application of Azadirachta indica (Neem) organic crude macerated extracts against postharvest decay of fruits caused by Penicillium expansum, Colletotrichum gloeosporioides and Botrytis cinerea (2025) · cites this paper as Yang et al., 2006
The introduction says steroidal saponins have long been known to have antifungal activity, particularly against agricultural pathogens. The Results and Discussion also report antifungal activity for some compounds, but the paper does not establish that they protect plants in vivo or protect against nonfungal pathogens. (LLM, conf=0.87)
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Research works printed but not linked: 4
- [17]17. Keating, G. M., and D. P. Figgitt. 2003. Caspofungin: a review of its use in esophageal candidiasis, invasive candidiasis and invasive aspergillosis. Drugs 63: 2235-2263.
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Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology
Jesus, M., Martins, A. P. J., Gallardo, E., & Silvestre, S. (2016) · Journal of Analytical Methods in Chemistry · doi:10.1155/2016/4156293 · Cited by 273 · see citing works
ALI, J., HUSSAIN, A., IKRAM, M., SIDDIQUE, M., ZAHOOR, M., ULLAH, R., IBRAHIM, M. A., GULFAM, N., & SHAH, A. B. (2025) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha53114086 · Cited by 3 · see citing works
- Authors
- Yang, C.-R., Zhang, Y., Jacob, M. R., Khan, S. I., Zhang, Y.-J., & Li, X.-C.
- Affiliations
- Kunming Institute of Botany (CN)
- University of Mississippi (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2006-05
- Volume
- 50
- Issue
- 5
- Pages
- 1710-1714
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2023002548
- Cited by
- 221
- References
- 0
- Citations by year
- 2026: 11 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 17 · 2020: 21 · 2019: 12 · 2018: 10 · 2017: 16 · 2016: 13 · 2015: 10 · 2014: 17 · 2013: 11 · 2012: 12
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (58‐6408‐2‐0009)
- National Institutes of Health
- Agricultural Research Service (58-6408-2- 0009)
- National Institute of Allergy and Infectious Diseases (R01AI027094, 27094, AI 27094)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Keywords
- antifungal activity, steroidal sapogenins, Candida albicans, Candida glabrata, Candida krusei, Cryptococcus neoformans, Aspergillus fumigatus, opportunistic fungal pathogens, aglycone structure, monocotyledonous plants, cytotoxicity, amphotericin B comparison
- MeSH terms
- Animals, Antifungal Agents, Aspergillosis, Aspergillus fumigatus, Candida, Candida albicans, Candidiasis, Chlorocebus aethiops, Cryptococcosis, Cryptococcus neoformans, Dose-Response Relationship, Drug, Female, Humans, Microbial Sensitivity Tests, Saponins, Vero Cells, Molecular Structure, Inhibitory Concentration 50, Candida glabrata, Cell Line, Tumor
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