Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Saponins as cytotoxic agents: a review

Podolak, I., Galanty, A., & Sobolewska, D. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9183-z · Cited by 703 · see citing works

Extraction and quantification of saponins: A review

Cheok, C. Y., Salman, H. A. K., & Sulaiman, R. (2014) · Food Research International · doi:10.1016/j.foodres.2014.01.057 · Cited by 450 · see citing works

Anticancer steroids: linking natural and semi-synthetic compounds

Salvador, J. A. R., Carvalho, J. F. S., Neves, M. A. C., Silvestre, S., Leitão, A. J., Silva, M. M., & Melo, M. L. S. E. (2012) · Natural Product Reports · doi:10.1039/c2np20082a · Cited by 279 · see citing works

Antioxidative and Hypolipidemic Effects of Diosgenin, a Steroidal Saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed Rats

Son, I. S., Kim, J. H., Sohn, H. Y., Son, K. H., Kim, J., & Kwon, C.-S. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70472 · Cited by 243 · see citing works

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

Chen, P.-S., Shih, Y., Huang, H.-C., & Cheng, H.-W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020164 · Cited by 225 · see citing works

Antifungal Activity of C-27 Steroidal Saponins

Yang, C.-R., Zhang, Y., Jacob, M. R., Khan, S. I., Zhang, Y.-J., & Li, X.-C. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1710-1714.2006 · Cited by 221 · see citing works

High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery

Attimarad, M., Ahmed, K. M., Al‐Dhubiab, B. E., & Sreeharsha, N. (2011) · Pharmaceutical Methods · doi:10.4103/2229-4708.84436 · Cited by 211 · see citing works

Cancer Chemopreventive and Therapeutic Effects of Diosgenin, a Food Saponin

Raju, J., & Mehta, R. (2009) · Nutrition and Cancer · doi:10.1080/01635580802357352 · Cited by 210 · see citing works

Cancer cell signaling pathways targeted by spice-derived nutraceuticals

Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204 · see citing works

Advances in the pharmacological activities and mechanisms of diosgenin

Chen, Y., Tang, Y., Yu, S., Han, Y., Kou, J., Liu, B., & Yu, B. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30053-4 · Cited by 192 · see citing works

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.

Li, F., Fernández, P., Rajendran, P., Hui, K. M., & Sethi, G. (2010) · Cancer Letters · doi:10.1016/j.canlet.2009.12.003 · Cited by 189 · see citing works

Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants

Turchan-Cholewo, J. T., Pocernich, C. B., Gairola, C. G., Chauhan, A., Schifitto, G., Butterfield, D. A., Buch, S. J., Narayan, O., Sinai, A. P., Geiger, J. D., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000042048.85204.3d · Cited by 186 · see citing works

Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

Liu, M., Wang, Z., Ju, Y., Wong, R. N., & Wu, Q. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-004-0849-3 · Cited by 181 · see citing works

Diosgenin targets Akt‐mediated prosurvival signaling in human breast cancer cells

Srinivasan, S., Koduru, S. V., Kumar, R., Venguswamy, G., Kyprianou, N., & Damodaran, C. (2009) · International Journal of Cancer · doi:10.1002/ijc.24419 · Cited by 159 · see citing works

Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma

Das, S., Dey, K. K., Dey, G., Pal, I., Majumder, A., Choudhury, S. M., Kundu, S. C., & Mandal, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046641 · Cited by 158 · see citing works

Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells

Corbière, C., Liagre, B., Bianchi, A., Bordji, K., Dauça, M., Netter, P., & Beneytout, J. (2003) · International Journal of Oncology · doi:10.3892/ijo.22.4.899 · Cited by 153 · see citing works

Steroidal saponins from Smilax china and their anti-inflammatory activities

Shao, B., Guo, H., Cui, Y., Ye, M., Han, J., & Guo, D. (2006) · Phytochemistry · doi:10.1016/j.phytochem.2006.10.026 · Cited by 150 · see citing works

Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues

Uemura, T., Hirai, S., Mizoguchi, N., Goto, T., Lee, J., Taketani, K., Nakano, Y., Shono, J., Hoshino, S., Tsuge, N., et al. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900609 · Cited by 150 · see citing works

Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

Ghosh, S., More, P. A., Derle, A., Patil, A. B., Markad, P. R., Asok, A., Kumbhar, N., Shaikh, M. L., Boppana, R., Shinde, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106039 · Cited by 145 · see citing works

A review on pharmacological and analytical aspects of diosgenin: a concise report

Patel, K., Gadewar, M. M., Tahilyani, V., & Patel, D. K. (2012) · Natural Products and Bioprospecting · doi:10.1007/s13659-012-0014-3 · Cited by 144 · see citing works

Diosgenin, 4-Hydroxyisoleucine, and Fiber from Fenugreek: Mechanisms of Actions and Potential Effects on Metabolic Syndrome

Fuller, S. E., & Stephens, J. M. (2015) · Advances in Nutrition · doi:10.3945/an.114.007807 · Cited by 143 · see citing works

Diosgenin, the Main Aglycon of Fenugreek, Inhibits LXRα Activity in HepG2 Cells and Decreases Plasma and Hepatic Triglycerides in Obese Diabetic Mice

Uemura, T., Goto, T., Kang, M., Mizoguchi, N., Hirai, S., Lee, J.-Y., Nakano, Y., Shono, J., Hoshino, S., Taketani, K., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125591 · Cited by 142 · see citing works

Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells

Lepage, C., Leger, D. Y., Bertrand, J., Martin, F., Beneytout, J., & Liagre, B. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.12.003 · Cited by 141 · see citing works

Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo

Gong, G., Yuan, Q., & Huang, W. Q. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.08.015 · Cited by 128 · see citing works

Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation

Jung, D., Park, H., Byun, H.-E., Park, Y.-M., Kim, T., Kim, B.-O., Um, S.-H., & Pyo, S. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.06.004 · Cited by 118 · see citing works

Antifungal Steroid Saponins fromDioscorea cayenensis

Sautour, M., Mitaine‐Offer, A., Miyamoto, T., Dongmo, A. B., & Lacaille‐Dubois, M. (2004) · Planta Medica · doi:10.1055/s-2004-815467 · Cited by 116 · see citing works

Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats

Kalailingam, P., Kannaian, B., Eevera, T., & Kaliaperumal, R. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.04.005 · Cited by 112 · see citing works

NMR spectroscopy of steroidal sapogenins and steroidal saponins: An update

Agrawal, P. K., Jain, D. C., & Pathak, A. K. (1995) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1260331202 · Cited by 111 · see citing works

Diosgenin Functionalized Iron Oxide Nanoparticles as Novel Nanomaterial Against Breast Cancer

Ghosh, S., More, P. A., Derle, A., Kitture, R., Kale, T., Gorain, M., Avasthi, A., Markad, P. R., Kundu, G. C., Kale, S. N., et al. (2015) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2015.11704 · Cited by 111 · see citing works

Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity

He, Z., Chen, H., Li, G., Zhu, H., Gao, Y., Zhang, L., & Sun, J. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.02.002 · Cited by 106 · see citing works

Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells

Jiang, S., Fan, J., Wang, Q., Ju, D., Feng, M., Li, J., Guan, Z.-B., An, D., Wang, X., & Li, Y. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.010 · Cited by 101 · see citing works

Comparative analysis of diosgenin in Dioscorea species and related medicinal plants by UPLC-DAD-MS

Yi, T., Fan, L., Chen, H., Zhu, G., Hau‐Man, S., Tang, Y., Chu, C., Chu, C., Zhao, Z., & Chen, H. (2014) · BMC Biochemistry · doi:10.1186/1471-2091-15-19 · Cited by 97 · see citing works

Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways

Choi, K.-W., Park, H., Jung, D., Kim, T., Park, Y.-M., Kim, B.-O., Sohn, E., Moon, E., Um, S. H., Rhee, D., et al. (2010) · Vascular Pharmacology · doi:10.1016/j.vph.2010.09.007 · Cited by 87 · see citing works

Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway

Kim, D. S., Jeon, B. K., Lee, Y. E., Woo, W.-H., & Mun, Y. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/981675 · Cited by 87 · see citing works

Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1

Lv, Y.-C., Yang, J., Yao, F., Xie, W., Tang, Y., Ouyang, X.-P., He, P., Tan, Y.-L., Li, L., Zhang, M., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.02.044 · Cited by 86 · see citing works

UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: A comparative study

Tang, Y., Pang, Y., He, X.-C., Zhang, Y., Zhang, J., Zhao, Z., Yi, T., & Chen, H. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.02.017 · Cited by 85 · see citing works

Microdetermination of Diosgenin from Fenugreek (Trigonella foenum-graecum) Seeds

Taylor, W. G., Elder, J. L., Chang, P. R., & Richards, K. W. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000467t · Cited by 85 · see citing works

Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm

Selim, S., & Jaouni, S. K. A. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0836-8 · Cited by 83 · see citing works

Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats

Okawara, M., Hashimoto, F., Todo, H., Sugibayashi, K., & Tokudome, Y. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.06.032 · Cited by 75 · see citing works

Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways

Liu, K., Zhao, W., Gao, X., Huang, F., Kou, J., & Liu, B. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.06.012 · Cited by 72 · see citing works

Analysis of Steroidal Sapogenins from Amber Fenugreek (Trigonella foenum-graecum) by Capillary Gas Chromatography and Combined Gas Chromatography/Mass Spectrometry

Taylor, W. G., Zaman, M. S., Mir, Z., Mir, P. S., Acharya, S. N., Mears, G. J., & Elder, J. L. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf960200n · Cited by 72 · see citing works

Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin

Hamid, A. A., Hasanain, M., Singh, A., Bhukya, B., Omprakash, Vasudev, P. G., Sarkar, J., Chanda, D., Khan, F., Aiyelaagbe, O. O., et al. (2014) · Steroids · doi:10.1016/j.steroids.2014.05.025 · Cited by 72 · see citing works

Role of oxidative stress, inflammation, nitric oxide and transforming growth factor-beta in the protective effect of diosgenin in monocrotaline-induced pulmonary hypertension in rats

Ahmed, L. A., Obaid, A. A. Z., Zaki, H. F., & Agha, A. M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.026 · Cited by 68 · see citing works

Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells

Li, Y., Wang, X., Cheng, S., Du, J., Deng, Z., Zhang, Y., LIU, Q., Gao, J., Cheng, B., & Ling, C. (2014) · Oncology Reports · doi:10.3892/or.2014.3629 · Cited by 68 · see citing works

Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells

Tong, Q., He, Y., Zhao, Q., Qing, Y., Huang, W. Q., & Wu, X. (2012) · Steroids · doi:10.1016/j.steroids.2012.04.019 · Cited by 66 · see citing works

Diosgenin, a Plant-Derived Sapogenin, Exhibits Antiviral Activity in Vitro against Hepatitis C Virus

Wang, Y.-J., Pan, K., Hsieh, T.-C., Chang, T., Lin, W., & Hsu, J. T.-A. (2011) · Journal of Natural Products · doi:10.1021/np100578u · Cited by 63 · see citing works

Diosgenin Inhibits hTERT Gene Expression in the A549 Lung Cancer Cell Line

Mohammad, R. Y., Ghareghomi, S., Gholamreza, H., Mobasseri, M., & Rasmi, Y. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.11.6945 · Cited by 61 · see citing works

Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS

Tohda, C., Lee, Y., Goto, Y., & Nemere, I. (2013) · Scientific Reports · doi:10.1038/srep03395 · Cited by 60 · see citing works

Diosgenin regulates adipokine expression in perivascular adipose tissue and ameliorates endothelial dysfunction via regulation of AMPK

Chen, Y., Xu, X., Zhang, Y., Liu, K., Huang, F., Liu, B., & Kou, J. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.005 · Cited by 59 · see citing works

Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa

Manda, V. K., Avula, B., Ali, Z., Wong, Y.-H., Smillie, T. J., Khan, I. A., & Khan, S. I. (2013) · Planta Medica · doi:10.1055/s-0033-1350699 · Cited by 59 · see citing works

Diosgenin Attenuates Allergen-Induced Intestinal Inflammation and IgE Production in a Murine Model of Food Allergy

Huang, C., Ku, C.-Y., & Jan, T. (2009) · Planta Medica · doi:10.1055/s-0029-1185578 · Cited by 59 · see citing works

Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line

Rahmati‐Yamchi, M., Ghareghomi, S., Gholamreza, H., Milani, M., Aghazadeh, M. H., & Daroushnejad, H. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3505-y · Cited by 58 · see citing works

Variation in Diosgenin Levels among 10 Accessions of Fenugreek Seeds Produced in Western Canada

Taylor, W. G., Zulyniak, H. J., Richards, K. W., Acharya, S. N., Bittman, S., & Elder, J. L. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020486y · Cited by 57 · see citing works

Modulatory Effects of Diosgenin on Attenuating the Key Enzymes Activities of Carbohydrate Metabolism and Glycogen Content in Streptozotocin-Induced Diabetic Rats

Saravanan, G., Ponmurugan, P., Deepa, M. A., & Senthilkumar, B. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2014.02.004 · Cited by 57 · see citing works

Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression

Leger, D. Y., Liagre, B., Corbière, C., Cook‐Moreau, J., & Beneytout, J. (2004) · International Journal of Oncology · doi:10.3892/ijo.25.3.555 · Cited by 56 · see citing works

Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats

Zhao, S., Niu, F., Xu, C.-Y., Liu, Y., Ye, L., Bi, G.-B., Chen, L., Tian, G., & Nie, T.-H. (2015) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-015-1309-2 · Cited by 54 · see citing works

Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring

Leger, D. Y., Liagre, B., Cardot, P. J. P., Beneytout, J., & Battu, S. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.09.008 · Cited by 54 · see citing works

High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio

Zhang, Z., Song, C., Fu, X., Liu, M., Li, Y., Pan, J., Liu, H., Wang, S., Xiang, L., Xiao, G. G., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150917130 · Cited by 53 · see citing works

Renoprotective effect of diosgenin in streptozotocin induced diabetic rats

Kanchan, D. M., Somani, G. S., Peshattiwar, V., Kaikini, A., & Sathaye, S. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2015.10.011 · Cited by 53 · see citing works

Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo

Zhang, R., Huang, B., Du, D., Guo, X., Xin, G., Xing, Z., Liang, Y. K., Chen, Y., Chen, Q., He, Y., et al. (2013) · Steroids · doi:10.1016/j.steroids.2013.07.003 · Cited by 49 · see citing works

A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis

Yang, H., Yin, H., Shen, Y., Xia, G., Zhang, B., Wu, X., Cai, B., & Tam, J. P. (2016) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2016.05.030 · Cited by 49 · see citing works

Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: role of mitochondrial ATP-sensitive potassium channels

Ebrahimi, H., Badalzadeh, R., Mohammadi, M., & Yousefi, B. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0320-9 · Cited by 46 · see citing works

Development and validation of a sensitive and rapid non-aqueous LC–ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: A comparative study

Xu, L., Liu, Y., Wang, T., Qi, Y., Han, X., Xu, Y., Peng, J., & Tang, X. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.03.039 · Cited by 45 · see citing works

Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin‐layer chromatography

Wang, L., Wang, X., Yuan, X., & Zhao, B. (2010) · Phytochemical Analysis · doi:10.1002/pca.1244 · Cited by 45 · see citing works

Anti-Proliferation and Anti-Invasion Effects of Diosgenin on Gastric Cancer BGC-823 Cells with HIF-1α shRNAs

Mao, Z.-J., Tang, Q., Zhang, C., Qin, Z., Pang, B., Wei, P.-K., Liu, B., & Chou, Y.-N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13056521 · Cited by 45 · see citing works

Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC‐ELSD

Avula, B., Wang, Y., Ali, Z., Smillie, T. J., & Khan, I. A. (2013) · Biomedical Chromatography · doi:10.1002/bmc.3019 · Cited by 44 · see citing works

Diosgenin Mitigates Streptozotocin Diabetes-induced Vascular Dysfunction of the Rat Aorta

Roghani, F., Roghani, M., & Baluchnejadmojarad, T. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000308 · Cited by 43 · see citing works

PPAR’s and Diosgenin a chemico biological insight in NIDDM

Sangeetha, M. K., Mal, N. S., Atmaja, K., Sali, V. K., & Vasanthi, H. R. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.08.014 · Cited by 43 · see citing works

Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-κB binding

Liagre, B., Bertrand, J., Leger, D. Y., & Beneytout, J. (2005) · International Journal of Molecular Medicine · doi:10.3892/ijmm.16.6.1095 · Cited by 42 · see citing works

Preparation of steroidal hormones with an emphasis on transformations of phytosterols and cholesterol - a review

Jasem, Y. A., Khan, M., Taha, A., & Thiemann, T. (2014) · Mediterranean Journal of Chemistry · doi:10.13171/mjc.3.2.2014.18.04.15 · Cited by 41 · see citing works

Microwave-assisted extraction and a new determination method for total steroid saponins from Dioscorea zingiberensis C.H. Wright

Ren, Y., Chen, Y., Hu, B., Wu, H., Lai, F., & Li, X. (2015) · Steroids · doi:10.1016/j.steroids.2015.09.008 · Cited by 40 · see citing works

A Validated Quantitative Thin-Layer Chromatographic Method for Estimation of Diosgenin in Various Plant Samples, Extract, and Market Formulation

Trivedi, P. D., Pundarikakshudu, K., Rathnam, S., & Shah, K. (2007) · Journal of AOAC International · doi:10.1093/jaoac/90.2.358 · Cited by 40 · see citing works

The effects of diosgenin in the Regulation of renal proximal tubular fibrosis

Wang, W., Liu, S., Chang, W., Shiue, Y., Hsieh, P., Hung, T., Hung, C., Hung, I. Y., Chen, M.-F., & Yang, Y. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.01.028 · Cited by 39 · see citing works

Solasodine and diosgenin: 1H and 13C assignments by two‐dimensional NMR spectroscopy

Puri, R., Wong, T. C., & Puri, R. K. (1993) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.1260310313 · Cited by 36 · see citing works

Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease

Cai, H., Wang, Z., Zhang, H., Wang, F., Yu, C., Zhang, F., Gao, L., Zhang, J., & Zhao, J. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.133 · Cited by 36 · see citing works

Anti-arrhythmic effect of diosgenin in reperfusion-induced myocardial injury in a rat model: activation of nitric oxide system and mitochondrial KATP channel

Badalzadeh, R., Yousefi, B., Majidinia, M., & Ebrahimi, H. (2014) · The Journal of Physiological Sciences · doi:10.1007/s12576-014-0333-8 · Cited by 35 · see citing works

Synthesis, characterization and biological studies of diosgenyl analogues

Huang, B., Du, D., Zhang, R., Wu, X., Xing, Z., He, Y., & Huang, W. Q. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.10.086 · Cited by 35 · see citing works

Diosgenin inhibits IL-1β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.

Wang, L., Ma, T., Zheng, Y., Lv, S., Yu, L., & Liu, S. (2015) · PubMed Central · Cited by 35 · see citing works

Sequential release of drugs from hollow manganese ferrite nanocarriers for breast cancer therapy

Kumar, B. N. P., Puvvada, N., Rajput, S., Sarkar, S., Das, S. K., Emdad, L., Sarkar, D., Venkatesan, P., Pal, I., Dey, G., et al. (2014) · Journal of Materials Chemistry B · doi:10.1039/c4tb01098a · Cited by 33 · see citing works

Qualitative and Quantitative Analysis of Microbial Transformation of Steroidal Saponins in Dioscorea zingiberensis

Qi, S., Dong, Y., Zhao, Y., & Xiu, Z. (2009) · Chromatographia · doi:10.1365/s10337-009-0978-2 · Cited by 32 · see citing works

Metabolite profiling of saponins in Balanites aegyptiaca plant tissues using LC (RI)-ESI/MS and MALDI-TOF/MS

Chapagain, B. P., & Wiesman, Z. (2008) · Metabolomics · doi:10.1007/s11306-008-0129-z · Cited by 31 · see citing works

Diosgenin quantification by HPLC in a Dioscorea polygonoides tuber collection from colombian flora

Niño, J., Jiménez, D. A., Mosquera, O. M., & Correa-Navarro, Y. M. (2007) · Journal of the Brazilian Chemical Society · doi:10.1590/s0103-50532007000500030 · Cited by 30 · see citing works

Metabolism of diosgenin-derived saponins: implications for hepatogenous photosensitization diseases in ruminants

Meagher, L. P., Smith, B. L., & Wilkins, A. L. (2001) · Animal Feed Science and Technology · doi:10.1016/s0377-8401(01)00223-1 · Cited by 29 · see citing works

Antimicrobial and inhibition on heat-induced protein denaturation of constituents isolated fromPolygonatumverticillatumrhizomes

Khan, H. Z., Saeed, M., Rauf, A., Khan, M. A., & Muhammad, N. (2015) · Natural Product Research · doi:10.1080/14786419.2014.996150 · Cited by 29 · see citing works

Quantitative determination of diosgenin in Dioscorea zingiberensis cell cultures by microplate-spectrophotometry and high-performance liquid chromatography

Li, P. (2012) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.440 · Cited by 29 · see citing works

Fenugreek seed extract and its phytocompounds- trigonelline and diosgenin arbitrate their hepatoprotective effects through attenuation of endoplasmic reticulum stress and oxidative stress in type 2 diabetic rats

Tharaheswari, M., Nakkala, J. R., Jeepipalli, S. P. K., Raja, K., Chandra, V. K., Mohan, V. K., & Sadras, S. R. (2014) · European Food Research and Technology · doi:10.1007/s00217-014-2322-9 · Cited by 28 · see citing works

Isolation and characterization of diosgenin from in vitro cultured tissues of Helicteres isora L

Deshpande, H. A., & Bhalsing, S. R. (2013) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-013-0205-3 · Cited by 28 · see citing works

Influence of plant matrix on microwave‐assisted extraction process. The case of diosgenin extracted from fenugreek (Trigonella foenum‐graecum L.)

Kaufmann, B., Rudaz, S. L., Cherkaoui, S., Veuthey, J., & Christen, P. (2006) · Phytochemical Analysis · doi:10.1002/pca.954 · Cited by 28 · see citing works

Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo

Zheng, H., Wei, Z., Xin, G., Ji, C., Wen, L., Xia, Q., Niu, H., & Huang, W. Q. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.05.032 · Cited by 28 · see citing works

Diosgenin-induced protection against myocardial ischaemia-reperfusion injury is mediated by mitochondrial K ATP channels in a rat model

Badalzadeh, R., Yousefi, B., Tajaddini, A., & Ahmadian, N. (2014) · Perfusion · doi:10.1177/0267659114566064 · Cited by 27 · see citing works

Diosgenin Modulates Vascular Smooth Muscle Cell Function by Regulating Cell Viability, Migration, and Calcium Homeostasis

Esfandiarei, M., Lam, J. T. N., Yazdi, S. A., Kariminia, A., Navarro‐Dorado, J., Kuzeljevic, B., Syyong, H. T., Hu, K., & van Breemen, C. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.172684 · Cited by 27 · see citing works

Development and Validation of HPTLC Method for Simultaneous Estimation of Diosgenin and Quercetin in Fenugreek Seeds (Trigonella foenum-graceum)

Laıla, O., Murtaza, I., Abdin, M. Z., Ahmad, S., Ganai, N. A., & Jehangir, M. (2014) · ISRN Chromatography · doi:10.1155/2014/583047 · Cited by 26 · see citing works

Effect of β-Cyclodextrin Derivatives on the Diosgenin Absorption in Caco-2 Cell Monolayer and Rats

Okawara, M., Tokudome, Y., Todo, H., Sugibayashi, K., & Hashimoto, F. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00560 · Cited by 26 · see citing works

Effects of total saponins from Rhizoma Dioscoreae Nipponicae on expression of vascular endothelial growth factor and angiopoietin-2 and Tie-2 receptors in the synovium of rats with rheumatoid arthritis

Guo, Y., Xing, E., Liang, X., Song, H., & Dong, W. (2016) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2015.10.012 · Cited by 26 · see citing works

Diosgenin inhibits tumor necrosis factor-induced tissue factor activity and expression in THP-1 cells via down-regulation of the NF-κB, Akt, and MAPK signaling pathways

Yang, H., Lei, Y. U. E., Jiang, W., Liu, Q., Kou, J., & Yu, B. (2013) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(13)60070-9 · Cited by 25 · see citing works

Newer Developments in HPLC Impacting Pharmaceutical Analysis : A Brief Review

Guillarme, D., & Dong, M. W. (2013) · Archive ouverte UNIGE (University of Geneva) · Cited by 24 · see citing works

Direct Biotransformation of Dioscin into Diosgenin in Rhizome of Dioscorea zingiberensis by Penicillium dioscin

Dong, J., Lei, C., Lu, D., & Wang, Y. (2014) · Indian Journal of Microbiology · doi:10.1007/s12088-014-0507-3 · Cited by 24 · see citing works

Diosgenin effectively suppresses skin inflammation induced by phthalic anhydride in IL-4/Luc/CNS-1 transgenic mice

Kim, J. E., Go, J., Koh, E. K., Song, S. H., Sung, J. E., Lee, H. A., Kim, D. S., Son, H. J., Lee, H. S., Lee, C. Y., et al. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1135040 · Cited by 24 · see citing works

Simultaneous determination of furostanol and spirostanol glycosides in Taiwanese yam (Dioscorea spp.) cultivars by high performance liquid chromatography

Yang, D.-J., Lu, T., & Hwang, L. S. (2020) · Journal of Food and Drug Analysis · doi:10.38212/2224-6614.2675 · Cited by 24 · see citing works

Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular alterations in chronic renal failure rats

Balamurugan, E., Manivannan, J., Sivasubramanian, J., & Arunagiri, P. (2013) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/2231-0738.114870 · Cited by 22 · see citing works

Rapid quantitative analysis of diosgenin in the tubers of Dioscorea zingiberensis C.H. Wright by coupling cellulose enzymolysis and two-phase acid hydrolysis in tandem with HPLC-UV

Yang, H., Chen, B., Wang, X.-B., Chue, P., Shen, Y., Xia, G.-H., & Jia, X. (2013) · Natural Product Research · doi:10.1080/14786419.2013.790030 · Cited by 22 · see citing works

Diosgenin quantification, characterisation and chemical composition in a tuber collection of D ioscorea spp. in the state of J alisco, M exico

Contreras-Pacheco, M. L., Santacruz‐Ruvalcaba, F., García-Fajardo, J. A., José de Jesús Sánchez, G., Ruíz-López, M. A., Estarrón‐Espinosa, M., & Castro‐Castro, A. (2013) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12193 · Cited by 22 · see citing works

Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts

Badalzadeh, R., Yavari, R., & Chalabiani, D. (2015) · General Physiology and Biophysics · doi:10.4149/gpb_2015009 · Cited by 22 · see citing works

A self-assembled nanoparticle platform based on poly(ethylene glycol)–diosgenin conjugates for co-delivery of anticancer drugs

Li, C., Dai, L., Liu, K., Deng, L., Pei, T., & Lei, J. (2015) · RSC Advances · doi:10.1039/c5ra15375a · Cited by 21 · see citing works

Efficient protocol for purification of diosgenin and two fatty acids from Rhizoma dioscoreae by SFE coupled with high‐speed counter‐current chromatography and evaporative light scattering detection

Xu, Y., Han, X., Dong, D., Xu, L., Qi, Y., Peng, J., & Zhan, L. (2008) · Journal of Separation Science · doi:10.1002/jssc.200800295 · Cited by 21 · see citing works

Determination of saponins in the kernel cake of Balanites aegyptiaca by HPLC‐ESI/MS

Chapagain, B. P., & Wiesman, Z. (2007) · Phytochemical Analysis · doi:10.1002/pca.990 · Cited by 21 · see citing works

LC–MSn characterization of steroidal saponins in Helleborus niger L. roots and their conversion products during fermentation

Duckstein, S. M., & Stintzing, F. C. (2014) · Steroids · doi:10.1016/j.steroids.2014.09.011 · Cited by 20 · see citing works

Diosgenin inhibits superoxide generation in FMLP-activated mouse neutrophils via multiple pathways

Lin, Y., Jia, R., Liu, Y., Gao, Y., Zeng, X., Kou, J., & Yu, B. (2014) · Free Radical Research · doi:10.3109/10715762.2014.966705 · Cited by 17 · see citing works

Steroidal saponin diosgenin from Dioscorea bulbifera protects cardiac cells from hypoxia -reoxygenation injury through modulation of pro -survival and pro -death molecules

Vasanthi, H. R., Jayachandran, K. S. P., & Gurusamy, N. (2016) · Pharmacognosy Magazine · doi:10.4103/0973-1296.176114 · Cited by 17 · see citing works

Determination of Diosgenin Content in Medicinal Plants with Enzyme-Linked Immunosorbent Assay

Li, J., Yang, D., Yu, K., He, J. L., & Zhang, Y. (2010) · Planta Medica · doi:10.1055/s-0030-1250054 · Cited by 14 · see citing works

Comparison between high performance liquid chromatography and high performance thin layer chromatography determination of Diosgenin from fenugreek seeds

Nagore, D. H., Patil, P., & Kuber, V. V. (2012) · International Journal of Green Pharmacy · doi:10.4103/0973-8258.108239 · Cited by 14 · see citing works

Quantitative determination of sarsasapogenin in rat plasma using liquid chromatography-tandem mass spectrometry

Yang, B., Liu, Z., Hu, J. Y., Lai, X., & Xia, P. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.04.020 · Cited by 13 · see citing works

Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study

Cao, X.-Z., Yao, Z., Chen, H., Dai, Y., Sun, P., Ye, W., & Yao, X. (2007) · Biomedical Chromatography · doi:10.1002/bmc.948 · Cited by 12 · see citing works

Improving Bone Microarchitecture in Aging with Diosgenin Treatment: A Study in Senescence-Accelerated OXYS Rats

Tikhonova, M. A. (2015) · The Chinese Journal of Physiology · doi:10.4077/cjp.2015.bad325 · Cited by 12 · see citing works

Effect of Modified Enzymatic Catalysis on the Extraction of Diosgenin from Dioscorea zingiberensis C. H. Wright

Zhang, Y. Q., Liang, J. H., Fu, E. H., & Li, B. (2007) · Chemical Engineering & Technology · doi:10.1002/ceat.200700234 · Cited by 10 · see citing works

A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma

Wang, J., Liu, J.-H., Guo, X., Zhang, J., & Yu, B. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.85 · Cited by 9 · see citing works

The Effect of Crude Diosgenin Extract from Purple and Yellow Greater Yams (Dioscorea alata L.) on the Lipid Profile of Dyslipidemia Rats

Harijono, H., Estiasih, T., Ariestiningsih, A. D., & Wardani, N. (2016) · Emirates Journal of Food and Agriculture · doi:10.9755/ejfa.2016-01-086 · Cited by 9 · see citing works

Purification and characterization of a glycosidase with hydrolyzing multi-3-O-glycosides of spirostanol saponin activity from Gibberella intermedia

Li, H., Wang, X., Ma, Y., Yang, N., Zhang, X., Xu, Z., & Jinsong, S. (2016) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2016.03.003 · Cited by 8 · see citing works

Quantification of anti-fertility compound-Diosgenin concentration in the fenugreek seeds aqueous extract (FSA)

Ahmed Kaid, N. A., Norbaiyah, M. B., Imad, M. A., & Norazian, M. H. (2016) · IIUM Medical Journal Malaysia · doi:10.31436/imjm.v15i1.410 · Cited by 8 · see citing works

ANTI-AMEBIC ACTIVITY OF DIOSGENIN ON NAEGLERIA FOWLERI TROPHOZOITES.

Rabablert, J., Tiewcharoen, S., Auewarakul, P., Atithep, T., Lumlerdkij, N., Vejaratpimol, R., & Junnu, V. (2015) · PubMed · Cited by 6 · see citing works

Development of a new certified reference material of diosgenin using mass balance approach and Coulometric titration method

Gong, N., Zhang, B., Hu, F., Du, H., Du, G., Gao, Z., & Lü, Y. (2014) · Steroids · doi:10.1016/j.steroids.2014.08.019 · Cited by 5 · see citing works

An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice

Taketani, K., Hoshino, S., Uemura, T., Goto, T., Takahashi, N., Tsuge, N., & Kawada, T. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.465 · Cited by 5 · see citing works

Quantitative Estimation of Piperine and Diosgenin in Ayurvedic formulation

Parameswaran, S. (2014) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2014/8310 · Cited by 5 · see citing works

Supramolecular prodrug micelles based on the complementary multiple hydrogen bonds as drug delivery platform for thrombosis therapy

Li, W., Wang, H., Wei, Z., Ning, J., Ma, L., Zheng, H., Niu, H., & Huang, W. Q. (2016) · RSC Advances · doi:10.1039/c6ra11110f · Cited by 5 · see citing works

The Dioscorea Genus (Yam)—An Appraisal of Nutritional and Therapeutic Potentials

Obidiegwu, J. E., Lyons, J. B., & Chilaka, C. A. (2020) · Foods · doi:10.3390/foods9091304 · Cited by 288 · see citing works

Green synthesis and characterization of zinc oxide nanoparticle using insulin plant ( Costus pictus D. Don ) and investigation of its antimicrobial as well as anticancer activities

Suresh, J., Pradheesh, G., Alexramani, V., Sundrarajan, M., & Hong, S. I. (2018) · Advances in Natural Sciences Nanoscience and Nanotechnology · doi:10.1088/2043-6254/aaa6f1 · Cited by 254 · see citing works

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

Sethi, G., Shanmugam, M. K., Warrier, S. R., Mérarchi, M., Arfuso, F., Kumar, A. P., & Bishayee, A. (2018) · Nutrients · doi:10.3390/nu10050645 · Cited by 254 · see citing works

Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants

Christ, B., Xu, C., Xu, M., Li, F., Wada, N., Mitchell, A. J., Han, X., Wen, M., Fujita, M., & Weng, J. (2019) · Nature Communications · doi:10.1038/s41467-019-11286-7 · Cited by 199 · see citing works

Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges

Singh, A. K., Singh, D. K., Kharwar, R. N., White, J. F., & Gond, S. K. (2021) · Microorganisms · doi:10.3390/microorganisms9010197 · Cited by 198 · see citing works

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal, P., Painuli, S., Abu-Izneid, T., Rauf, A., Sharma, A., Daştan, S. D., Kumar, M., Alshehri, M. M., Taheri, Y., Das, R., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1035441 · Cited by 195 · see citing works

An underutilized orphan tuber crop—Chinese yam : a review

Epping, J., & Laibach, N. (2020) · Planta · doi:10.1007/s00425-020-03458-3 · Cited by 174 · see citing works

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

Parama, D., Boruah, M., Yachna, K., Rana, V., Banik, K., Harsha, C., Thakur, K. K., Dutta, U., Arya, A., Mao, X., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118182 · Cited by 155 · see citing works

Green synthesis and characterization of hexagonal shaped MgO nanoparticles using insulin plant ( Costus pictus D. Don) leave extract and its antimicrobial as well as anticancer activity

Suresh, J., Pradheesh, G., Alexramani, V., Sundrarajan, M., & Hong, S. I. (2018) · Advanced Powder Technology · doi:10.1016/j.apt.2018.04.003 · Cited by 131 · see citing works

Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: Viral and cancer signaling mechanisms

Mu, C., Sheng, Y., Wang, Q., Amin, A., Li, X., & Xie, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104149 · Cited by 128 · see citing works

Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances

Cai, B., Zhang, Y., Wang, Z., Xu, D., Jia, Y., Guan, Y., Liao, A., Liu, G., Chun, C., & Li, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3153082 · Cited by 124 · see citing works

The role of diosgenin in diabetes and diabetic complications

Gan, Q., Wang, J., Hu, J., Lou, G., Xiong, H., Peng, C., Zheng, S., & Huang, Q. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105575 · Cited by 119 · see citing works

Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research

Passos, F. R. S., Araújo-Filho, H. G., Monteiro, B. S., Shanmugam, S., Araújo, A. A. D. S., Almeida, J. R. G. D. S., Thangaraj, P., Quintans‐Júnior, L. J., & Quintans, J. D. S. S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153842 · Cited by 110 · see citing works

The origin and evolution of the diosgenin biosynthetic pathway in yam

Cheng, J. G., Chen, J., Liu, X., Li, X., Zhang, W., Dai, Z., Lu, L., Zhou, X., Cai, J., Zhang, X., et al. (2020) · Plant Communications · doi:10.1016/j.xplc.2020.100079 · Cited by 89 · see citing works

Diosgenin-loaded niosome as an effective phytochemical nanocarrier: physicochemical characterization, loading efficiency, and cytotoxicity assay

Hajizadeh, M. R., Parvaz, N., Barani, M., Khoshdel, A., Fahmidehkar, M. A., Mahmoodi, M., & Torkzadeh‐Mahani, M. (2019) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-019-00277-0 · Cited by 74 · see citing works

Dioscorea Plants: A Genus Rich in Vital Nutra-pharmaceuticals-A Review.

Salehi, B., Şener, B., Kılıç, M., Sharifi‐Rad, J., Naz, R., Yousaf, Z., Mudau, F. N., Fokou, P. V. T., Ezzat, S. M., Bishbishy, M. H. E., et al. (2019) · PubMed Central · doi:10.22037/ijpr.2019.112501.13795 · Cited by 71 · see citing works

Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces

Gupta, D. D., Mishra, S., Verma, S. S., Shekher, A., Rai, V., Awasthee, N., Das, T. J., Paul, D., Das, S. K., Tag, H., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113842 · Cited by 64 · see citing works

Cardiotoxicity of doxorubicin-based cancer treatment: What is the protective cognition that phytochemicals provide us?

Liu, C., Ma, X., Zhuang, J., Liu, L., & Sun, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105062 · Cited by 61 · see citing works

Highly Selective Sensing Platform Utilizing Graphene Oxide and Multiwalled Carbon Nanotubes for the Sensitive Determination of Tramadol in the Presence of Co‐Formulated Drugs

Mohamed, M. A., Atty, S. A., Salama, N. N., & Banks, C. E. (2016) · Electroanalysis · doi:10.1002/elan.201600668 · Cited by 60 · see citing works

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

Rabha, B., Bharadwaj, K. K., Baishya, D., Sarkar, T., Edinur, H. A., & Pati, S. (2021) · Polymers · doi:10.3390/polym13081322 · Cited by 58 · see citing works

Potato Glycoalkaloids: occurrence, biological activities and extraction for biovalorisation – a review

Benkeblia, N. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14330 · Cited by 55 · see citing works

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Hu, Y., Chen, X., Hu, M., Zhang, D., Yuan, S., Li, P., & Feng, L. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00666-9 · Cited by 61 · see citing works

A synthetic diosgenin primary amine derivative attenuates LPS-stimulated inflammation via inhibition of NF-κB and JNK MAPK signaling in microglial BV2 cells

Cai, B., Seong, K.-J., Bae, S., Chun, C., Kim, W.-J., & Jung, J. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.05.021 · Cited by 56 · see citing works

The Emerging Role of Natural Products in Cancer Treatment

Ghosh, S., Das, S., Sinha, K., Ghosh, B., Sen, K., Ghosh, N., & Sil, P. C. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03786-3 · Cited by 54 · see citing works

Comprehensive review on natural pharmacophore tethered 1,2, 3‐triazoles as active pharmaceuticals

Rammohan, A., Venkatesh, B. C., Basha, N. M., Zyryanov, G. V., & Nageswararao, M. (2022) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14148 · Cited by 51 · see citing works

Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins

Sobolewska, D., Galanty, A., Grabowska, K., Makowska‐Wąs, J., Wróbel‐Biedrawa, D., & Podolak, I. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09661-0 · Cited by 53 · see citing works

Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India

Adhikari, P. P., Talukdar, S., & Borah, A. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.07.024 · Cited by 52 · see citing works

Current perspectives on fenugreek bioactive compounds and their potential impact on human health: A review of recent insights into functional foods and other high value applications

Alu'datt, M. H., Rababah, T., Al‐ali, S., Tranchant, C. C., Gammoh, S., Alrosan, M., Kubow, S. J., Tan, T., & Ghatasheh, S. (2024) · Journal of Food Science · doi:10.1111/1750-3841.16970 · Cited by 51 · see citing works

Assessment of behavioral changes and antitumor effects of silver nanoparticles synthesized using diosgenin in mice model

Rajadurai, U. M., Hariharan, A., Siva, D., Ameén, F., Dawoud, T. M. S., Alwakeel, S., Palanivel, I., Prabha, A. L., & Jacob, J. A. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102766 · Cited by 50 · see citing works

Diosgenin: Chemistry, extraction, quantification and health benefits

Arya, P., Munshi, M., & Kumar, P. (2022) · Food Chemistry Advances · doi:10.1016/j.focha.2022.100170 · Cited by 50 · see citing works

Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis

Wang, D., & Wang, X. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s368836 · Cited by 49 · see citing works

The greater yam (Dioscorea alata L.): A review of its phytochemical content and potential for processed products and biofortification

Lebot, V., Lawac, F., & Legendre, L. (2022) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2022.104987 · Cited by 49 · see citing works

The effect of propolis plus Hyoscyamus niger L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to COVID ‐19: A clinical trial

Kosari, M., Noureddini, M., Khamechi, S. P., Najafi, A., Ghaderi, A., Sehat, M., & Banafshe, H. R. (2021) · Phytotherapy Research · doi:10.1002/ptr.7116 · Cited by 48 · see citing works

Diosgenin attenuates nonalcoholic hepatic steatosis through the hepatic FXR-SHP-SREBP1C/PPARα/CD36 pathway

Chen, S., Sun, S., Feng, Y., Li, X., Yin, G., Liang, P., Yu, W., Meng, D., Zhang, X., Liu, H., et al. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175808 · Cited by 44 · see citing works

Phytomedicines Used for Diabetes Mellitus in Ghana: A Systematic Search and Review of Preclinical and Clinical Evidence

Adinortey, M. B., Agbeko, R., Boison, D., Ekloh, W., Kuatsienu, L. E., Biney, E. E., Affum, O. O., Kwarteng, J., & Nyarko, A. K. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/6021209 · Cited by 47 · see citing works

Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1‐dependent pathway

Zhang, X., Lu, Y., Li, W., Tao, T., Wang, W., Gao, S., Zhou, Y., Guo, Y., Liu, C., Zhuang, Z., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15507 · Cited by 44 · see citing works

Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin

Tewari, D., Priya, A., Bishayee, A., & Bishayee, A. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.795 · Cited by 46 · see citing works

LC-MS/MS and GC-MS Identification of Metabolites from the Selected Herbs and Spices, Their Antioxidant, Anti-Diabetic Potential, and Chemometric Analysis

Kiani, H. S., Ali, B., Al‐Sadoon, M. K., Al-Otaibi, H. S., & Ali, A. (2023) · Processes · doi:10.3390/pr11092721 · Cited by 42 · see citing works

Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis

Li, J., Liang, Q., Li, C., Liu, M., & Zhang, Y. (2018) · Molecules · doi:10.3390/molecules23020454 · Cited by 38 · see citing works

Ophiopogonin D′, a Natural Product From Radix Ophiopogonis, Induces in Vitro and in Vivo RIPK1-Dependent and Caspase-Independent Apoptotic Death in Androgen-Independent Human Prostate Cancer Cells

Lu, Z., Wang, H., Zhu, M., Song, W., Wang, J., Wu, C.-P., Kong, Y., Guo, J., Li, N., Liu, J., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00432 · Cited by 37 · see citing works

Recent developments in the enzymatic modifications of steroid scaffolds

Wang, H., & Abe, I. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob00327f · Cited by 36 · see citing works

Recent Advances in Metabolites from Medicinal Plants in Cancer Prevention and Treatment

Mir, M. A., Hamdani, S. S., Sheikh, B. A., & Mehraj, U. (2019) · Current Immunology Reviews · doi:10.2174/1573395515666191102094330 · Cited by 35 · see citing works

Diosgenin a steroidal compound: An emerging way to cancer management

Arya, P., & Kumar, P. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.14005 · Cited by 35 · see citing works

Diosgenin and Its Fenugreek Based Biological Matrix Affect Insulin Resistance and Anabolic Hormones in a Rat Based Insulin Resistance Model

Kiss, R., Pesti‐Asbóth, G., Szarvas, M. M., Stündl, L., Cziáky, Z., Hegedűs, C., Kovács, D. K., Badale, A., Máthé, E., Szilvássy, Z., et al. (2019) · BioMed Research International · doi:10.1155/2019/7213913 · Cited by 34 · see citing works

Exploring the medicinally important secondary metabolites landscape through the lens of transcriptome data in fenugreek (Trigonella foenum graecum L.)

Naika, M. B. N., Sathyanarayanan, N., Sajeevan, R. S., Bhattacharyya, T., Ghosh, P., Iyer, M., Mahita, J., Joshi, A. G., Harini, K., Shafi, K. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17779-8 · Cited by 34 · see citing works

Diosgenin protects retinal pigment epithelial cells from inflammatory damage and oxidative stress induced by high glucose by activating AMPK/Nrf2/HO‐1 pathway

Yang, H., & Gao, X. (2022) · Immunity Inflammation and Disease · doi:10.1002/iid3.698 · Cited by 34 · see citing works

Endophytic sources of diosgenin, a natural steroid with multiple therapeutic values

Biswas, D., Nazir, R., Biswas, P., Kumar, V., Nandy, S., Mukherjee, A., Dey, A., & Pandey, D. K. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.04.009 · Cited by 33 · see citing works

Elevated expression of diosgenin-related genes and stimulation of the defense system in Trigonella foenum-graecum (Fenugreek) by cold plasma treatment

Ebrahimibasabi, E., Ebrahimi, A., Momeni, M., & Amerian, M. R. (2020) · Scientia Horticulturae · doi:10.1016/j.scienta.2020.109494 · Cited by 33 · see citing works

Simultaneous quantification of allantoin and steroidal saponins in yam (Dioscorea spp.) powders

Lebot, V., Faloye, B., Okon, E. U., & Guèye, B. (2019) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2019.02.001 · Cited by 32 · see citing works

Regulation of reactive oxygen species by phytochemicals for the management of cancer and diabetes

Lim, H. M., & Park, S. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2025574 · Cited by 30 · see citing works

Metabolome Profiling of Eight Chinese Yam (Dioscorea polystachya Turcz.) Varieties Reveals Metabolite Diversity and Variety Specific Uses

Zeng, X., Liu, D., & Huang, L. (2021) · Life · doi:10.3390/life11070687 · Cited by 29 · see citing works

Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach

Akash, S., Bayıl, İ., Mahmood, S., Mukerjee, N., Mili, T. A., Dhama, K., Rahman, M. A., Maitra, S., Mohany, M., Al-Rejaie, S. S., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20670 · Cited by 29 · see citing works

Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Al‐Shuhaib, M. B. S., & Al‐Shuhaib, J. M. B. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401754 · Cited by 29 · see citing works

A Network Pharmacology Approach to Uncover the Mechanisms of Shen‐Qi‐Di‐Huang Decoction against Diabetic Nephropathy

Di, S., Han, L., Wang, Q., Liu, X., Yang, Y., Li, F., Zhao, L., & Tong, X. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7043402 · Cited by 28 · see citing works

Nephroprotective role of diosgenin in gentamicin-induced renal toxicity: biochemical, antioxidant, immunological and histopathological approach

Mishra, P., Mandlik, D. S., Arulmozhi, S., & Mahadik, K. R. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00318-z · Cited by 28 · see citing works

Exploring the potential of diosgenin as a promising antitumor agent through comprehensive spectroscopic characterization, solvent–solute interactions, topological properties, Hirshfeld surface, and molecular docking interactions with 2NZT and 2I1V proteins

Kumar, A. R., Selvaraj, S., Vickram, A. S., Mol, G. P. S., Awasthi, S., Thirunavukkarasu, M., Selvaraj, M., & Basumatary, S. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.125349 · Cited by 27 · see citing works

An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease

Aaron, P. A., Vu, K., & Gelli, A. (2020) · mBio · doi:10.1128/mbio.01249-20 · Cited by 27 · see citing works

Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Sharma, N., Singhal, M., Kumari, R. M., Gupta, N., Manchanda, R., Syed, A., Bahkali, A. H., & Nimesh, S. (2020) · Biomolecules · doi:10.3390/biom10121679 · Cited by 27 · see citing works

Diosgenin Modulates Oxidative Stress and Inflammation in High-Fat Diet-Induced Obesity in Mice

Khateeb, S., Albalawi, A. E., & Alkhedaide, A. Q. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s355677 · Cited by 27 · see citing works

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Cai, D., Qi, J., Yang, Y., Zhang, W., Zhou, F., Jia, X., Guo, W., Huang, X., Gao, F., Chen, H., et al. (2019) · Molecules · doi:10.3390/molecules24224025 · Cited by 26 · see citing works

Costus afer: A Systematic Review of Evidence-Based Data in support of Its Medicinal Relevance

Boison, D., Adinortey, C. A., Babanyinah, G. K., Quasie, O., Agbeko, R., Wiabo-Asabil, G. K., & Adinortey, M. B. (2019) · Scientifica · doi:10.1155/2019/3732687 · Cited by 26 · see citing works

Diosgenin increased DDX3 expression in hepatocellular carcinoma.

Yu, H., Liu, Y., Niu, C., & Cheng, Y. (2018) · Europe PMC (PubMed Central) · Cited by 26 · see citing works

Cheilocostus speciosus extract-assisted naringenin-encapsulated poly-ε-caprolactone nanoparticles: evaluation of anti-proliferative activities

Rabha, B., Bharadwaj, K. K., Boro, N., Ghosh, A., Gogoi, S. K., Varma, R. S., & Baishya, D. (2021) · Green Chemistry · doi:10.1039/d1gc02260a · Cited by 25 · see citing works

Fabrication and Assessment of Diosgenin Encapsulated Stearic Acid Solid Lipid Nanoparticles for Its Anticancer and Antidepressant Effects Using in vitro and in vivo Models

Khan, H., Nazir, S., Farooq, R. K., Khan, I. N., & Javed, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.806713 · Cited by 31 · see citing works

Switchgrass Metabolomics Reveals Striking Genotypic and Developmental Differences in Specialized Metabolic Phenotypes

Li, X., Sarma, S. J., Sumner, L. W., Jones, A. D., & Last, R. L. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01306 · Cited by 24 · see citing works

Fenugreek derived diosgenin as an emerging source for diabetic therapy

Tak, Y., Kaur, M., Chitranashi, A., Samota, M. K., Verma, P., Bali, M., & Kumawat, C. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1280100 · Cited by 31 · see citing works

Diosgenin: an important natural pharmaceutical active ingredient

Huang, N., Yu, D., Wu, J., & Du, X.-W. (2021) · Food Science and Technology · doi:10.1590/fst.94521 · Cited by 24 · see citing works

An update on the biological and pharmacological activities of diosgenin

Kim, J. K., & Park, S. U. (2018) · EXCLI journal · doi:10.17179/excli2017-894 · Cited by 24 · see citing works

Use of genome editing technologies for genetic improvement of crops of tropical origin

Rojas-Vásquez, R., & Gatica-Arias, A. (2019) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-019-01707-2 · Cited by 23 · see citing works

Effects of diosgenin on the skeletal system in rats with experimental type 1 diabetes

Londzin, P., Kisiel-Nawrot, E., Kocik, S., Janas, A., Trawczyński, M., Cegieła, U., & Folwarczna, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110342 · Cited by 23 · see citing works

Pharmacokinetic Profile and Oral Bioavailability of Diosgenin, Charantin, and Hydroxychalcone From a Polyherbal Formulation

Salunkhe, R., Gadgoli, C. H., Naik, A. A., & Patil, N. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.629272 · Cited by 22 · see citing works

Diosgenin protects against alveolar bone loss in ovariectomized rats via regulating long non‑coding RNAs

Zhang, Z., Chen, Y., Xiang, L., Wang, Z., Xiao, G. G., & Ju, D. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6681 · Cited by 22 · see citing works

Diosgenin exerts its tumor suppressive function via inhibition of Cdc20 in osteosarcoma cells

Long, C., Chen, J., Zhou, H., Jiang, T., Fang, X., Hou, D., Liu, P., & Duan, H. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1568748 · Cited by 22 · see citing works

Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

Iweala, E., Adurosakin, O. E., Ugochukwu, I., Omonhinmin, C. A., Dania, O. E., & Ugbogu, E. A. (2024) · Sci · doi:10.3390/sci6020036 · Cited by 21 · see citing works

Yam as functional food: bioactive properties, health benefits, and applications

Tareen, M. B. K., Saeed, N., Sultan, M., Chen, X., Li, J., & Yan, S. (2025) · Food, Nutrition and Health. · doi:10.1007/s44403-025-00022-3 · Cited by 21 · see citing works

Development of HP-TLC method for rapid quantification of sugars, catechins, phenolic acids and saponins to assess Yam (Dioscorea spp.) tuber flour quality

Lebot, V., Malapa, R., & Molisalé, T. (2018) · Plant Genetic Resources · doi:10.1017/s1479262118000333 · Cited by 21 · see citing works

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

Pathak, N., & Negi, A. S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116915 · Cited by 20 · see citing works

The phytoestrogen, diosgenin, directly stimulates ovarian cell functions in two farm animal species

Sirotkin, A. V., Alexa, R., Alwasel, S. H., & Harrath, A. H. (2019) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2019.04.002 · Cited by 20 · see citing works

Antidiabetic activity of root tubers of Asparagus gonoclados Baker in streptozotocin induced diabetic rats

Rajasekhar, A., Peddanna, K., Vedasree, N., Munirajeswari, P., Nagaraju, N., Badri, K. R., & Chippada, A. R. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112027 · Cited by 20 · see citing works

Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans

Gutierrez‐Gongora, D., & Geddes‐McAlister, J. (2022) · FACETS · doi:10.1139/facets-2021-0157 · Cited by 19 · see citing works

Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats

Javed, M., Saleem, A., & Akhtar, M. F. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01244-7 · Cited by 19 · see citing works

Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-α by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1

Yang, W. S., Moon, S. Y., Lee, M. J., Lee, E. K., & Park, S.-K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484396 · Cited by 19 · see citing works

Health Benefits of Bioactive Compounds from Vegetables

Rashmi, H. B., & Negi, P. S. (2020) · Springer eBooks · doi:10.1007/978-981-15-1761-7_5 · Cited by 19 · see citing works

Diosgenin prevents periodontitis by inhibiting inflammation and promoting osteogenic differentiation

Cong, S., Peng, Q., Cao, L., Yi, Q., Liu, Y., Li, L., Tong, Q., & Liang, D. (2023) · Oral Diseases · doi:10.1111/odi.14708 · Cited by 18 · see citing works

Pharmacologically active compounds from latex-bearing plants

Warowicka, A., Nawrot, R., & Goździcka‐Józefiak, A. (2019) · Advances in botanical research · doi:10.1016/bs.abr.2019.11.002 · Cited by 20 · see citing works

Characterization of the interaction of diosgenin with human serum albumin and α1-acid glycoprotein using biophysical and bioinformatic tools

Bakar, K. A., Lam, S. D., Sidek, H. M., & Feroz, S. R. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.112865 · Cited by 17 · see citing works

CURRENT HIGHLIGHTS ON BIOCHEMICAL AND PHARMACOLOGICAL PROFILE OF DIOSCOREA ALATA : A REVIEW

Kaur, B., Khatun, S., & Suttee, A. (2021) · PLANT ARCHIVES · doi:10.51470/plantarchives.2021.v21.s1.085 · Cited by 17 · see citing works

Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Zhao, H., Zhang, X., Zhang, B., & Qu, X. (2021) · Open Life Sciences · doi:10.1515/biol-2021-0075 · Cited by 17 · see citing works

Phytochemical Profiling of Tupistra nutans Wall. ex Lindl. Inflorescence Extract and Evaluation of Its Antioxidant Activity and Toxicity in Hepatocarcinoma (HepG2) and Fibroblast (F111) Cells

Roy, A. C., Prasad, A., & Ghosh, I. (2022) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-022-04145-7 · Cited by 19 · see citing works

Therapeutic potential and research progress of diosgenin for lipid metabolism diseases

Zhang, S., Liang, P., Feng, Y., Yin, G., Sun, F., Ma, C., & Zhang, F. (2022) · Drug Development Research · doi:10.1002/ddr.21991 · Cited by 17 · see citing works

Terpenes

Xavier, V., Spréa, R. M., Finimundy, T. C., Heleno, S. A., Amaral, J. S., Barros, L., & Ferreira, I. C. F. R. (2023) · Springer eBooks · doi:10.1007/978-3-031-18587-8_5 · Cited by 20 · see citing works

Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy

Mori, A., Ishikawa, K., Saiki, S., Hatano, T., Oji, Y., Okuzumi, A., Fujimaki, M., Koinuma, T., Ueno, S., Imamichi, Y., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223113 · Cited by 17 · see citing works

Comparative bioactivity analysis of hydro-methanolic extracts of root, leaf, and inflorescence of Tupistra nutans Wall. ex Lindl: An in vitro study on antioxidant and anti-hepatocellular carcinoma activity

Roy, A. C., Prasad, A., Singh, S., Priya, K., & Ghosh, I. (2023) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2023.102819 · Cited by 16 · see citing works

Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats

Kusano, Y., Tsujihara, N., Masui, H., Shibata, T., Uchida, K., & TAKEUCHI, W. (2019) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.65.421 · Cited by 16 · see citing works

Diversified synthesis and α-selective glycosylation of 3-amino-2,3,6-trideoxy sugars

Zeng, J., Wang, R., Yao, W., Zhang, S., Sun, G., Liao, Z., Meng, L., & Wan, Q. (2018) · Organic Chemistry Frontiers · doi:10.1039/c8qo00948a · Cited by 16 · see citing works

Southern African Soap Plants and Screening of Selected Phytochemicals and Quantitative Analysis of Saponin Content

Mohlakoana, M., & Moteetee, A. N. (2021) · Resources · doi:10.3390/resources10100096 · Cited by 15 · see citing works

Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist

Schwarz, P. F., Perhal, A. F., Schöberl, L. N., Kraus, M. M., Kirchmair, J., & Dirsch, V. M. (2022) · Biomedicines · doi:10.3390/biomedicines10092076 · Cited by 16 · see citing works

Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts

Yang, X., Nomoto, K., & Tohda, C. (2020) · Journal of Natural Medicines · doi:10.1007/s11418-020-01451-4 · Cited by 15 · see citing works

Bioactive components to inhibit foam cell formation in atherosclerosis

Singh, S., Changkija, S., Mudgal, R. K., & Ravichandiran, V. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07039-9 · Cited by 15 · see citing works

In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum

Okokon, J. E., Etuk, I. C., Thomas, P. S., Drijfhout, F. P., Claridge, T. D. W., & Li, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113153 · Cited by 15 · see citing works

Development and Validation of Sensitive HPLC-UV-DAD Method for Determination of Diosgenin in Plants of Species of Dioscorea Genus

da Silva, L. R. G., Cheibub, A. M. D. S. S., Valverde, A. L., & Netto, A. D. P. (2019) · Revista Virtual de Química · doi:10.21577/1984-6835.20190090

DIOSGENIN: AN INTEGRATED REVIEW OF CHEMICAL RESEARCH, ANALYTICAL TECHNIQUES, AI APPLICATIONS, AND SAFETY: A Comprehensive Review

Meghana, D., Bhavana, A., Kasthuri, B., Nikhila, A., Yaswanth, A., Chowdary, D. Y. A., & Madhuri, M. V. B. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.23011253

Estimation of Diosgenin by HPLC in a Dioscorea zingiberensis Collection from Different Local Markets in Middle and South Iraq

Al-Yassiry, Z. A. N., Jebor, M. A., & Al-Alwani, B. (2024) · International Journal of Scientific Research in Biological Sciences

Development and Validation of an HPLC Method for Diosgenin, A Bioactive Compound in the Rhizomes of Chamaecostus cuspidatus

Saliya, H., Madam, J., Patel, H. D., Lakhani, M., Patel, V., Shah, L., Vyas, V., & Shah, M. B. (2025) · Pharmacognosy Research · doi:10.5530/pres.20252199 · Cited by 1 · see citing works

Method Development for Quantitative Determination of Diosgenin from the Seeds of Fenugreek, Trigonella foenum-graecum L.

Sukhanov, A. E., Ставрианиди, А. Н., Кубасова, Е. Д., Panasyuk, A. S., & Buyuklinskaya, O. V. (2020) · Drug development & registration · doi:10.33380/2305-2066-2020-9-3-150-156