CoChat
Sign Up
Cited by 40Oral microbiology and periodontitis researchBacterial biofilms and quorum sensingNeonatal and Maternal Infections

Determinants of the developing oral flora in normal newborns

Open access
Long, S S, Swenson, R M·1976·Applied and Environmental Microbiology
DOI 10.1128/aem.32.4.494-497.1976PMC PMC170295
Open this paper in CoChat — free accountOpen PDF

Abstract

The ability of Streptococcus species to selectively adhere to the oral epithelial cells of newborns was studied in vitro. On day 1 of life, mucosal cells from normal infants demonstrated selective attraction for the natural distribution of streptococci that would soon colonize these surfaces. Streptococcus salivarius and Streptococcus mitis adhered well in vitro to scraped cells from cheek and tongue surfaces. Streptococcus mutans, on the other hand, exhibited feeble or no adherence to cheek or tongue cells. Adherence of Escherichia coli to oral epithelial cells was also studied. The ability of strains of E. coli to adhere to cheek and tongue cells correlated solely with the presence of cell surface substances, probably pili. These observations, made on infants at the critical moment of their developing flora, strengthen the hypothesis that the ability of bacteria to adhere to surfaces is an important determinant of their ecological place in the oral microflora.

Integrity signals

Registry

Crossref · 10.1128/aem.32.4.494-497.1976

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Persistence of periodontal inflammation can result in residual pockets and persistent periodontal bacteria, leading to new tissue destruction.

    “The persistence of periodontal inflammation can result in residual pockets and the persistent of periodontal bacteria, leading to new tissue destruction [16,17].”

    From A Cross-Talk between Diet and the Oral Microbiome: Balance of Nutrition on Inflammation and Immune System’s Response during Periodontitis (2022) · cites this paper as [17]

  • Pioneer microbial colonizers of the oral cavity, such as Streptococcus mitis, Streptococcus sanguinis, Streptococcus gordonii, and Streptococcus salivarius, can bind selectively to tongue and cheek cells before the teeth emerge and can outcompete other microbial species.

    “Pioneer microbial colonizers of the oral cavity, such as Streptococcus mitis, Streptococcus sanguinis, Streptococcus gordonii, and Streptococcus salivarius, display core characteristics that make them well suited to this specific niche as they are able to bind selectively to tongue and cheek cells before the teeth emerge and can outcompete other microbial species.17, 19”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [19]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Long, S. S., & Swenson, R. M.
ORCID
Long, S S
Venue
Applied and Environmental Microbiology
Publisher
American Society for Microbiology
Published
1976-10
Volume
32
Issue
4
Pages
494-497
ISSN
  • 0099-2240 (ISSN-L)
  • 1098-5336
DOI
10.1128/aem.32.4.494-497.1976
PMC
PMC170295
OpenAlex
W1590121978
Cited by
40
References
22
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 2 · 2017: 2 · 2015: 2 · 2012: 1
FWCI
2.53
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Applied and Environmental Microbiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
oral microbiota, neonates, bacterial adhesion, oral epithelial cells, Streptococcus salivarius, Streptococcus mitis, Streptococcus mutans, Escherichia coli, fimbriae, cell surface adhesins, oral colonization
MeSH terms
Cells, Cultured, Escherichia coli, Humans, Infant, Newborn, Mouth Mucosa, Species Specificity, Streptococcus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review