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Growth and Detachment of Cell Clusters from Mature Mixed-Species Biofilms
Open accessAbstract
Detachment from biofilms is an important consideration in the dissemination of infection and the contamination of industrial systems but is the least-studied biofilm process. By using digital time-lapse microscopy and biofilm flow cells, we visualized localized growth and detachment of discrete cell clusters in mature mixed-species biofilms growing under steady conditions in turbulent flow in situ. The detaching biomass ranged from single cells to an aggregate with a diameter of approximately 500 μm. Direct evidence of local cell cluster detachment from the biofilms was supported by microscopic examination of filtered effluent. Single cells and small clusters detached more frequently, but larger aggregates contained a disproportionately high fraction of total detached biomass. These results have significance in the establishment of an infectious dose and public health risk assessment.
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Cited by
Biofilms as Complex Differentiated Communities
Stoodley, P., Sauer, K., Davies, D. G., & Costerton, J. W. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160705 · Cited by 3,158
Self-citationThe role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · APMIS · doi:10.1111/apm.12099 · Cited by 1,080
Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
Kaplan, J. B. (2010) · Journal of Dental Research · doi:10.1177/0022034509359403 · Cited by 949
Nguyen, T., Roddick, F., & Fan, L. (2012) · Membranes · doi:10.3390/membranes2040804 · Cited by 802
Dowd, S. E., Sun, Y., Secor, P. R., Rhoads, D. D., Wolcott, B. M., James, G. A., & Wolcott, R. D. (2008) · BMC Microbiology · doi:10.1186/1471-2180-8-43 · Cited by 784
Metadata
- Authors
- Stoodley, P., Wilson, S., Hall-Stoodley, L., Boyle, J. D., Lappin-Scott, H. M., & Costerton, J. W.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2001-12
- Volume
- 67
- Issue
- 12
- Pages
- 5608-5613
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2042447089
- Cited by
- 365
- References
- 0
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stoodley, P., Wilson, S., Hall-Stoodley, L., Boyle, J. D., Lappin-Scott, H. M., & Costerton, J. W. (2001). Growth and Detachment of Cell Clusters from Mature Mixed-Species Biofilms. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.67.12.5608-5613.2001
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