The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Type III Secretion Systems and Disease
Open accessAbstract
SUMMARY: Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-negative pathogens with a unique virulence mechanism enabling them to inject bacterial effector proteins directly into the host cell cytoplasm, bypassing the extracellular milieu. Although the effector proteins vary among different T3SS pathogens, common pathogenic mechanisms emerge, including interference with the host cell cytoskeleton to promote attachment and invasion, interference with cellular trafficking processes, cytotoxicity and barrier dysfunction, and immune system subversion. The activity of the T3SSs correlates closely with infection progression and outcome, both in animal models and in human infection. Therefore, to facilitate patient care and improve outcomes, it is important to understand the T3SS-mediated virulence processes and to target T3SSs in therapeutic and prophylactic development efforts.
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Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127
Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole
Birmingham, C. L., Smith, A. C., Bakowski, M. A., Yoshimori, T., & Brumell, J. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509157200 · Cited by 658
Cited by
Qin, S., Xiao, W., Zhou, C., Pu, Q., Deng, X., Lan, L., Liang, H., Song, X., & Wu, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01056-1 · Cited by 1,703
Verocytotoxin-producing Escherichia coli (VTEC)
Karmali, M. A., Gannon, V., & Sargeant, J. M. (2010) · Veterinary Microbiology · doi:10.1016/j.vetmic.2009.04.011 · Cited by 543
Functional domains and motifs of bacterial type III effector proteins and their roles in infection
Dean, P. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00271.x · Cited by 285
Type V secretion: mechanism(s) of autotransport through the bacterial outer membrane
Leo, J. C., Grin, I., & Linke, D. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0208 · Cited by 269
Metabolomics as an Emerging Tool for the Study of Plant–Pathogen Interactions
Castro-Moretti, F. R., Gentzel, I. N., Mackey, D., & Alonso, A. P. (2020) · Metabolites · doi:10.3390/metabo10020052 · Cited by 269
Metadata
- Authors
- Coburn, B., Sekirov, I., & Finlay, B. B.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2007-10
- Volume
- 20
- Issue
- 4
- Pages
- 535-549
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2143398242
- Cited by
- 644
- References
- 3
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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