The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Rifampin Combination Therapy for Nonmycobacterial Infections
Open accessAbstract
SUMMARY: The increasing emergence of antimicrobial-resistant organisms, especially methicillin-resistant Staphylococcus aureus (MRSA), has resulted in the increased use of rifampin combination therapy. The data supporting rifampin combination therapy in nonmycobacterial infections are limited by a lack of significantly controlled clinical studies. Therefore, its current use is based upon in vitro or in vivo data or retrospective case series, all with major limitations. A prominent observation from this review is that rifampin combination therapy appears to have improved treatment outcomes in cases in which there is a low organism burden, such as biofilm infections, but is less effective when effective surgery to obtain source control is not performed. The clinical data support rifampin combination therapy for the treatment of prosthetic joint infections due to methicillin-sensitive S. aureus (MSSA) after extensive debridement and for the treatment of prosthetic heart valve infections due to coagulase-negative staphylococci. Importantly, rifampin-vancomycin combination therapy has not shown any benefit over vancomycin monotherapy against MRSA infections either clinically or experimentally. Rifampin combination therapy with daptomycin, fusidic acid, and linezolid needs further exploration for these severe MRSA infections. Lastly, an assessment of the risk-benefits is needed before the addition of rifampin to other antimicrobials is considered to avoid drug interactions or other drug toxicities.
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Cites
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Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726
Practice Guidelines for the Management of Bacterial Meningitis
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Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
Campbell, E. A., Korzheva, N., Mustaev, A., Murakami, K., Nair, S., Goldfarb, A., & Darst, S. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00286-0 · Cited by 1,556 · cited 2×
“There is no consistent pattern in which amino acids can be affected within the rpoB gene to cause resistance; however, codons 531 and 522 appear to be most frequently involved (41, 268).”
BackgroundMethicillin-Resistant Staphylococcus aureus Disease in Three Communities
Fridkin, S. K., Hageman, J. C., Morrison, M., Sanza, L. T., Como-Sabetti, K., Jernigan, J. A., Harriman, K., Harrison, L. H., Lynfield, R., & Farley, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043252 · Cited by 1,493
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Staphylococcus aureus Prosthetic Valve Endocarditis: Optimal Management and Risk Factors for Death
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Living with motor neurone disease: lives, experiences of services and suggestions for change
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Cited by
Bradley, J. S., Byington, C. L., Shah, S. S., Alverson, B., Carter, E. R., Harrison, C., Kaplan, S. L., Mace, S. E., McCracken, G. H., Moore, M. R., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir531 · Cited by 1,919
Coagulase-Negative Staphylococci
Becker, K., Heilmann, C., & Peters, G. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-13 · Cited by 1,628
Intracellular staphylococcus aureus: Live-in and let die
Fraunholz, M., & Sinha, B. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00043 · Cited by 377
Bretonnière, C., Jozwiak, M., Girault, C., Beuret, P., Trouillet, J.-L., Anguel, N., Caillon, J., Potel, G., Villers, D., Boutoille, D., et al. (2015) · Critical Care · doi:10.1186/s13054-015-1021-7 · Cited by 24
Metadata
- Authors
- Forrest, G. N., & Tamura, K.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2010-01
- Volume
- 23
- Issue
- 1
- Pages
- 14-34
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2124010765
- Cited by
- 242
- References
- 11
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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