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Zika Virus
Open accessAbstract
Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the family Flaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of the Flavivirus genus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such as Aedes aegypti and Aedes albopictus.
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“The ICR suckling mice model is susceptible for ZIKV infection by using both i.p. and i.c. injection methods and provide infection with high viral loads in the brain, which is consistent with severe neurological symptom in human [12, 14, 25].”
From ICR suckling mouse model of Zika virus infection for disease modeling and drug validation (2018) · cites this paper as [25]
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Metadata
- Authors
- Musso, D., & Gubler, D. J.
- Affiliations
- Institut Louis Malardé (PF)
- Partnership for Dengue Control (FR)
- Corresponding author
- Musso, Didier
- Gubler, Duane J.
- ORCID
- Musso, Didier
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2016-07
- Volume
- 29
- Issue
- 3
- Pages
- 487-524
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- PMC
- PMC4861986
- OpenAlex
- W4210967474
- Cited by
- 1,469
- References
- 409
- Citations by year
- 2026: 67 · 2025: 91 · 2024: 111 · 2023: 135 · 2022: 129 · 2021: 142 · 2020: 157 · 2019: 145 · 2018: 161 · 2017: 201 · 2016: 126
- FWCI
- 208.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- Zika virus, arboviruses, flavivirus, Flaviviridae, mosquito-borne transmission, Zika virus infection, neurological complications, microcephaly, congenital malformations, serological diagnosis, cross-reactivity, Aedes aegypti, Aedes albopictus, urban mosquito vectors, disease emergence, dengue, chikungunya
- MeSH terms
- Zika Virus Infection, Zika Virus, Animals, Disease Outbreaks, Humans, Insect Vectors, Phylogeny, Urban Renewal, Early Diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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