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Candida Infections of the Genitourinary Tract
Abstract
SUMMARY: All humans are colonized with Candida species, mostly Candida albicans , yet some develop diseases due to Candida , among which genitourinary manifestations are extremely common. The forms of genitourinary candidiasis are distinct from each other and affect different populations. While vulvovaginal candidiasis affects mostly healthy women, candiduria occurs typically in elderly, hospitalized, or immunocompromised patients and in neonates. Despite its high incidence and clinical relevance, genitourinary candidiasis is understudied, and therefore, important questions about pathogenesis and treatment guidelines remain to be resolved. In this review, we summarize the current knowledge about genitourinary candidiasis.
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“C. glabrata is also a causative agent of urinary tract and vaginal infections [10,11].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [11]
In the citing paper
“It usually resides as a commensal in the gastrointestinal and genitourinary tracts and in the oral and conjunctival flora [1–5]. However, it causes infection when the host becomes debilitated or immunocompromised.”
From Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [3]
In the citing paper
“Candida albicans is the most important fungal opportunistic pathogen.”
From Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [3]
In the citing paper
“It is a member of the healthy microbiota, asymptomatically colonizing the gastrointestinal (GI) tract, reproductive tract, oral cavity, and skin of most humans (1, 64, 87, 97, 99).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [1]
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Metadata
- Authors
- Achkar, J. M., & Fries, B. C.
- Affiliations
- Departments of Medicine
- Albert Einstein College of Medicine (US)
- Corresponding author
- Fries, Bettina C.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2010-04
- Volume
- 23
- Issue
- 2
- Pages
- 253-273
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2124826696
- Semantic Scholar
- 17626a0160a09be223f4c10f181b66d025d1d20a
- Cited by
- 736
- References
- 299
- Citations by year
- 2026: 40 · 2025: 48 · 2024: 39 · 2023: 45 · 2022: 65 · 2021: 65 · 2020: 71 · 2019: 54 · 2018: 53 · 2017: 56 · 2016: 52 · 2015: 41 · 2014: 44 · 2013: 29 · 2012: 20
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Microbiology Reviews (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI-059681, K23AI067665, AI-51519, AI067665, P30AI051519, R01AI059681)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- Candida, vaginal candidiasis, candiduria, Candida albicans, Candida colonization, pathogenesis, antifungal therapy, immunocompromised patients
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