The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease
Open accessAbstract
SUMMARY: The source of the severe acute respiratory syndrome (SARS) epidemic was traced to wildlife market civets and ultimately to bats. Subsequent hunting for novel coronaviruses (CoVs) led to the discovery of two additional human and over 40 animal CoVs, including the prototype lineage C betacoronaviruses, Tylonycteris bat CoV HKU4 and Pipistrellus bat CoV HKU5; these are phylogenetically closely related to the Middle East respiratory syndrome (MERS) CoV, which has affected more than 1,000 patients with over 35% fatality since its emergence in 2012. All primary cases of MERS are epidemiologically linked to the Middle East. Some of these patients had contacted camels which shed virus and/or had positive serology. Most secondary cases are related to health care-associated clusters. The disease is especially severe in elderly men with comorbidities. Clinical severity may be related to MERS-CoV's ability to infect a broad range of cells with DPP4 expression, evade the host innate immune response, and induce cytokine dysregulation. Reverse transcription-PCR on respiratory and/or extrapulmonary specimens rapidly establishes diagnosis. Supportive treatment with extracorporeal membrane oxygenation and dialysis is often required in patients with organ failure. Antivirals with potent in vitro activities include neutralizing monoclonal antibodies, antiviral peptides, interferons, mycophenolic acid, and lopinavir. They should be evaluated in suitable animal models before clinical trials. Developing an effective camel MERS-CoV vaccine and implementing appropriate infection control measures may control the continuing epidemic.
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Cites
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Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor
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Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60
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Cited by
Coronavirus Disease 2019 (COVID-19): A Perspective from China
Zu, Z. Y., Jiang, M. D., Xu, P. P., Chen, W., Ni, Q. Q., Lu, G. M., & Zhang, L. J. (2020) · Radiology · doi:10.1148/radiol.2020200490 · Cited by 2,070
“ARDS= acute respiratory distress syndrome COVID-19 = Coronavirus Disease 19 GGO = ground-glass opacity MERS = Middle East respiratory syndrome RT-PCR = reverse-transcription–polymerase-chain-reaction SARS = severe acute respiratory syndrome SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2 In Pre ss”
BackgroundInfluentialZoonotic diseases: etiology, impact, and control
Rahman, M. T., Sobur, M. A., Islam, M. S., Ievy, S., Hossain, M. J., El Zowalaty, M. E., Rahman, A. T., & Ashour, H. M. (2020) · Microorganisms · doi:10.3390/microorganisms8091405 · Cited by 853
Yang, Y., Yang, M., Shen, C., Wang, F., Yuan, J., Li, J., Zhang, M., Wang, Z., Xing, L., Wei, J., et al. (2020) · doi:10.1101/2020.02.11.20021493 · Cited by 836
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Shrock, E., Fujimura, E., Kula, T., Timms, R. T., Lee, I.-H., Leng, Y., Robinson, M. L., Sie, B. M., Li, M. Z., Chen, Y., et al. (2020) · Science · doi:10.1126/science.abd4250 · Cited by 678
Chu, H., Chan, J. F.-W., Yuen, T. T.-T., Shuai, H., Yuan, S., Wang, Y., Hu, B., Yip, C. C.-Y., Tsang, J. O.-L., Huang, X., et al. (2020) · The Lancet Microbe · doi:10.1016/s2666-5247(20)30004-5 · Cited by 748
Self-citation
Metadata
- Authors
- Chan, J. F. W., Lau, S. K. P., To, K. K. W., Cheng, V. C. C., Woo, P. C. Y., & Yuen, K.-Y.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2015-04
- Volume
- 28
- Issue
- 2
- Pages
- 465-522
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2115555188
- Cited by
- 881
- References
- 8
- FWCI
- 33.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Chan, J. F. W., Lau, S. K. P., To, K. K. W., Cheng, V. C. C., Woo, P. C. Y., & Yuen, K.-Y. (2015). Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00102-14
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