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Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study
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Caco-2 cell line expresses ACE2 receptor and thus is a model cell line for SARS-CoV-2 infection and replication studies.
“we used the human colon epithelial cell line Caco-2 that expresses ACE2 receptor and thus is a model cell line for SARS-CoV-2 infection and replication studies42.”
From The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness (2022) · cites this paper as [42]
Caco-2 expresses the virus receptor ACE2.
“We used lentiviral transfection to construct stable Caco-2 cell lines expressing A3A, A3G, and A1 + A1CF to study the effect of APOBEC on SARS-CoV-2 replication because Caco-2 expresses the virus receptor ACE242.”
From The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness (2022) · cites this paper as [42]
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Cites
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Neurological associations of COVID-19
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Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
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“Notably, infected h3ACs did not show substantial cytopathies, such as cell degeneration and syncytium formation (Chu et al., 2020), and maintained cell viability, unlike Vero cells (Figures 2E and S2).”
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Metadata
- Authors
- Chu, H., Chan, J. F.-W., Yuen, T. T.-T., Shuai, H., Yuan, S., Wang, Y., Hu, B., Yip, C. C.-Y., Tsang, J. O.-L., Huang, X., Chai, Y., Yang, D., Hou, Y., Chik, K. K.-H., Zhang, X., Fung, A. Y.-F., Tsoi, H.-W., Cai, J.-P., Chan, W.-M., Ip, J. D., Chu, A. W.-H., Zhou, J., Lung, D. C., Kok, K.-H., To, K. K.-W., Tsang, O. T.-Y., Chan, K.-H., & Yuen, K.-Y.
- Venue
- The Lancet Microbe
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 1
- Issue
- 1
- Pages
- e14-e23
- ISSN
- 2666-5247
- PMC
- PMC7173822
- Cited by
- 748
- References
- 4
- Language
- en
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