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Occurrence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli
Open accessAbstract
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea worldwide. Four categories of antigens have been commonly studied: O serogroup, H serogroup, colonization factor antigens (CFA), and toxins. A database has been complied from published reports of nearly 1,000 ETEC isolates from 18 locations and analyzed to determine the occurrence, distribution, and associations of O serogroup, H serogroup, CFA, and toxin type. Tables listing the associations of antigens are presented. This analysis documents the widespread nature and variety of ETEC. Even the most common combination of antigens, O6:H16 CFA/II LTST, accounted for only 11% of the ETEC isolates in the database. It was isolated from 12 locations. Many phenotypes occurred only once. CFA detection based on enzyme-linked antibodies with polyclonal sera is suggested as the preferred assay. A combination of CFA and toxin-based antigens is suggested as the most practical vaccine.
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Cited by
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583
Diarrheagenic Escherichia coli
Gomes, T. A. T., Elias, W. P., Scaletsky, I. C. A., Guth, B. E. C., Rodrigues, J. F., Piazza, R. M. F., Ferreira, L. C. S., & Martinez, M. B. (2016) · Brazilian Journal of Microbiology · doi:10.1016/j.bjm.2016.10.015 · Cited by 1,158
The structures of Escherichia coli O-polysaccharide antigens
Stenutz, R., Weintraub, A., & Widmalm, G. (2006) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2006.00016.x · Cited by 406
Infection strategies of enteric pathogenic Escherichia coli
Clements, A., Young, J. C., Constantinou, N., & Frankel, G. (2012) · Gut Microbes · doi:10.4161/gmic.19182 · Cited by 351
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Schultz, M. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20377 · Cited by 310
Metadata
- Authors
- Wolf, M. K.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 1997-10
- Volume
- 10
- Issue
- 4
- Pages
- 569-584
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2138875570
- Cited by
- 308
- References
- 0
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Occurrence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli. https://app.cochat.ai/papers/10.1128/cmr.10.4.569
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- Wolf, M. K. (1997). Occurrence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.10.4.569
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