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Cited by 1,082

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Helicobacter pylori

Open access
Dunn, B E, Cohen, H, Blaser, M J·1997·Clinical Microbiology Reviews

Abstract

Helicobacter pylori is a gram-negative bacterium which causes chronic gastritis and plays important roles in peptic ulcer disease, gastric carcinoma, and gastric lymphoma. H. pylori has been found in the stomachs of humans in all parts of the world. In developing countries, 70 to 90% of the population carries H. pylori. In developed countries, the prevalence of infection is lower. There appears to be no substantial reservoir of H. pylori aside from the human stomach. Transmission can occur by iatrogenic, fecal-oral, and oral-oral routes. H. pylori is able to colonize and persist in a unique biological niche within the gastric lumen. All fresh isolates of H. pylori express significant urease activity, which appears essential to the survival and pathogenesis of the bacterium. A variety of tests to diagnose H. pylori infection are now available. Histological examination of gastric tissue, culture, rapid urease testing, DNA probes, and PCR analysis, when used to test gastric tissue, all require endoscopy. In contrast, breath tests, serology, gastric juice PCR, and urinary excretion of [15N]ammonia are noninvasive tests that do not require endoscopy. In this review, we highlight advances in the detection of the presence of the organism and methods of differentiating among types of H. pylori, and we provide a background for appropriate chemotherapy of the infection.

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Metadata

Authors
Dunn, B. E., Cohen, H., & Blaser, M. J.
Venue
Clinical Microbiology Reviews
Published
1997-10
Volume
10
Issue
4
Pages
720-741
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W4211017205
Cited by
1,082
References
16
FWCI
46.89
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Helicobacter pylori. https://app.cochat.ai/papers/10.1128/cmr.10.4.720
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Dunn, B. E., Cohen, H., & Blaser, M. J. (1997). Helicobacter pylori. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.10.4.720

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