The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Exotoxins of Staphylococcus aureus
Abstract
SUMMARY: This article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and staphylococcal food poisoning. The family of staphylococcal PTSAgs presently includes toxic shock syndrome toxin-1 (TSST-1) and most of the staphylococcal enterotoxins (SEs) (SEA, SEB, SEC, SED, SEE, SEG, and SEH). As the name implies, the PTSAgs are multifunctional proteins that invariably exhibit lethal activity, pyrogenicity, superantigenicity, and the capacity to induce lethal hypersensitivity to endotoxin. Other properties exhibited by one or more staphylococcal PTSAgs include emetic activity (SEs) and penetration across mucosal barriers (TSST-1). A detailed review of the molecular mechanisms underlying the toxicity of the staphylococcal hemolysins is also presented.
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Citations
Cites
Staphylococcus aureus alpha-toxin. Dual mechanism of binding to target cells
Hildebrand, A., Pohl, M., & Bhakdi, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47358-4 · Cited by 196
Cited by
Food Poisoning and Staphylococcus aureus Enterotoxins
Argudín, M. Á., Mendoza, M. C., & Rodicio, M. R. (2010) · Toxins · doi:10.3390/toxins2071751 · Cited by 1,161
Bacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threat
Zetola, N., Francis, J. S., Nuermberger, E. L., & Bishai, W. R. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70112-2 · Cited by 791
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Ellis, M. W., Hospenthal, D. R., Dooley, D. P., Gray, P. J., & Murray, C. K. (2004) · Clinical Infectious Diseases · doi:10.1086/423965 · Cited by 448
Metadata
- Authors
- Dinges, M. M., Orwin, P. M., & Schlievert, P. M.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2000-01
- Volume
- 13
- Issue
- 1
- Pages
- 16-34
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W4211016618
- Cited by
- 967
- References
- 1
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dinges, M. M., Orwin, P. M., & Schlievert, P. M. (2000). Exotoxins of Staphylococcus aureus. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.13.1.16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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