The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Molecular Aspects of Severe Malaria
Open accessAbstract
SUMMARY: Human infections with Plasmodium falciparum may result in severe forms of malaria. The widespread and rapid development of drug resistance in P. falciparum and the resistance of the disease-transmitting mosquitoes to insecticides make it urgent to understand the molecular background of the pathogenesis of malaria to enable the development of novel approaches to combat the disease. This review focuses on the molecular mechanisms of severe malaria caused by the P. falciparum parasite. The nature of severe malaria and the deleterious effects of parasite-derived toxins and host-induced cytokines are introduced. Sequestration, brought about by cytoadherence and rosetting, is linked to severe malaria and is mediated by multiple receptors on the endothelium and red blood cells. P. falciparum erythrocyte membrane protein 1 (PfEMP1) is the ligand responsible for a majority of binding interactions, and the multiply adhesive features of this sticky molecule are presented. Antigenic variation is also a major feature of PfEMP1 and of the surface of the P. falciparum-infected erythrocyte. Possible mechanisms of P. falciparum antigenic variation in asexual stages are further discussed. We conclude this review with a perspective and suggestions of important aspects for future investigations.
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Cited by
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,746
Bousema, T., & Drakeley, C. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-10 · Cited by 746
The ABO blood group system and Plasmodium falciparum malaria
Cserti, C. M., & Dzik, W. H. (2007) · Blood · doi:10.1182/blood-2007-03-077602 · Cited by 320
Tuteja, R. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05997.x · Cited by 302
Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum
Barry, A. E., Leliwa-Sytek, A., Tavul, L., Imrie, H., Migot-Nabias, F., Brown, S. M., McVean, G. A. V., & Day, K. P. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030034 · Cited by 199
Metadata
- Authors
- Chen, Q., Schlichtherle, M., & Wahlgren, M.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2000-07
- Volume
- 13
- Issue
- 3
- Pages
- 439-450
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2099299834
- Cited by
- 242
- References
- 7
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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