Cited by 1,154Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisMycobacterium research and diagnosis

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Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

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Smith, Issar·2003·Clinical Microbiology Reviews

DOI 10.1128/cmr.16.3.463-496.2003PMC PMC164219

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Abstract

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major causes of mortality, since two million people die each year from this malady. TB has many manifestations, affecting bone, the central nervous system, and many other organ systems, but it is primarily a pulmonary disease that is initiated by the deposition of Mycobacterium tuberculosis, contained in aerosol droplets, onto lung alveolar surfaces. From this point, the progression of the disease can have several outcomes, determined largely by the response of the host immune system. The efficacy of this response is affected by intrinsic factors such as the genetics of the immune system as well as extrinsic factors, e.g., insults to the immune system and the nutritional and physiological state of the host. In addition, the pathogen may play a role in disease progression since some M. tuberculosis strains are reportedly more virulent than others, as defined by increased transmissibility as well as being associated with higher morbidity and mortality in infected individuals. Despite the widespread use of an attenuated live vaccine and several antibiotics, there is more TB than ever before, requiring new vaccines and drugs and more specific and rapid diagnostics. Researchers are utilizing information obtained from the complete sequence of the M. tuberculosis genome and from new genetic and physiological methods to identify targets in M. tuberculosis that will aid in the development of these sorely needed antitubercular agents.

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Items 201–322 of 322

Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages
Bange, F. C., Brown, A. M., & Jacobs, W. R. (1996) · Infection and Immunity · doi:10.1128/iai.64.5.1794-1799.1996 · Cited by 126
An Inhibitor of Exported Mycobacterium tuberculosis Glutamine Synthetase Selectively Blocks the Growth of Pathogenic Mycobacteria in Axenic Culture and in Human Monocytes: Extracellular Proteins as Potential Novel Drug Targets
Harth, G., & Horwitz, M. A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.9.1425 · Cited by 125
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Hinds, J., Mahenthiralingam, E., Kempsell, K. E., Duncan, K., Stokes, R. W., Parish, T., & Stoker, N. G. (1999) · Microbiology · doi:10.1099/13500872-145-3-519 · Cited by 125
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Brosch, R., Gordon, S. V., Pym, A. S., Eiglmeier, K., Garnier, T., & Cole, S. T. (2000) · International Journal of Medical Microbiology · doi:10.1016/s1438-4221(00)80083-1 · Cited by 123
Corynebacterium parvum- and Mycobacterium bovis bacillus Calmette-Guerin-induced granuloma formation is inhibited in TNF receptor I (TNF-RI) knockout mice and by treatment with soluble TNF-RI
Senaldi, G., Yin, S., Shaklee, C. L., Piguet, P. F., Mak, T. W., & Ulich, T. R. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.11.5022 · Cited by 122
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Wards, B. J., de Lisle, G. W., & Collins, D. M. (2000) · Tubercle and Lung Disease · doi:10.1054/tuld.2000.0244 · Cited by 122
Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex.
Collins, D. M., Kawakami, R. P., de Lisle, G. W., Pascopella, L., Bloom, B. R., & Jacobs, W. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8036 · Cited by 121
Host microarray analysis reveals a role for the Salmonella response regulator phoP in human macrophage cell death
Detweiler, C. S., Cunanan, D. B., & Falkow, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091110098 · Cited by 119
An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative‐stress response
Dussurget, O., Rodriguez, M., & Smith, I. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.1461511.x · Cited by 118
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Crystal Structure of the Iron-dependent Regulator (IdeR) from Mycobacteriumtuberculosis Shows Both Metal Binding Sites Fully Occupied
Pohl, E., Holmes, R. K., & Hol, W. G. J. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2339 · Cited by 117
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits
Fortin, A., Diez, E., Rochefort, D., Laroche, L., Malo, D., Rouleau, G. A., Gros, P., & Skamene, E. (2001) · Genomics · doi:10.1006/geno.2001.6528 · Cited by 116
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Stokes, R. W., & Doxsee, D. D. (1999) · Cellular Immunology · doi:10.1006/cimm.1999.1554 · Cited by 114
Purification and Characterization of the Mycobacterium smegmatis Catalase-Peroxidase Involved in Isoniazid Activation
Marcinkeviciene, J. A., Magliozzo, R. S., & Blanchard, J. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22290 · Cited by 111
The identification of rofA, a positive‐acting regulatory component of prtF expression: use of an mγδ‐based shuttle mutagenesis strategy in Streptococcus pyogenes
Fogg, G. C., Gibson, C. M., & Caparon, M. G. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00345.x · Cited by 111
Proteins ofMycobacterium bovisBCG Induced in the Wayne Dormancy Model
Boon, C., Li, R., Qi, R. Z., & Dick, T. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.8.2672-2676.2001 · Cited by 111
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Alland, D., Kramnik, I., Weisbrod, T. R., Otsubo, L., Cerny, R., Miller, L. P., Jacobs, W. R., & Bloom, B. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13227 · Cited by 110
Expression of a Gene for a Porin-Like Protein of the OmpA Family fromMycobacterium tuberculosisH37Rv
Senaratne, R. H., Mobasheri, H., Papavinasasundaram, K. G., Jenner, P., Lea, E. J. A., & Draper, P. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.14.3541-3547.1998 · Cited by 110
WhiD and WhiB, Homologous Proteins Required for Different Stages of Sporulation in Streptomyces coelicolor A3(2)
Molle, V., Palframan, W. J., Findlay, K., & Buttner, M. J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.5.1286-1295.2000 · Cited by 110
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Oh, S., & Chater, K. F. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.1.122-127.1997 · Cited by 109
Proteomics Reveals Open Reading Frames in Mycobacterium tuberculosis H37Rv Not Predicted by Genomics
Jungblut, P. R., Müller, E., Mattow, J., & Kaufmann, S. H. E. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5905-5907.2001 · Cited by 108
Evidence of selection for protein introns in the recAs of pathogenic mycobacteria.
Davis, E. O., Thangaraj, H. S., Brooks, P. C., & Colston, M. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06309.x · Cited by 106
Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties
Wilson, T. M., de Lisle, G. W., Marcinkeviciene, J. A., Blanchardand, J. S., & Collins, D. M. (1998) · Microbiology · doi:10.1099/00221287-144-10-2687 · Cited by 105
Dependence of Mycobacterium bovis BCG on Anaerobic Nitrate Reductase for Persistence Is Tissue Specific
Fritz, C., Maass, S., Kreft, A., & Bange, F. (2002) · Infection and Immunity · doi:10.1128/iai.70.1.286-291.2002 · Cited by 104
Novel Mycobacterium tuberculosis anti‐σ factor antagonists control σF activity by distinct mechanisms
Beaucher, J., Rodrigue, S., Jacques, P., Smith, I., Brzeziński, R., & Gaudreau, L. R. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03135.x · Cited by 103
Self-citation
Cloning and assessment of mycobacterial promoters by using a plasmid shuttle vector
GUPTA, S. K., Bashyam, M. D., & Tyagi, A. K. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.16.5186-5192.1993 · Cited by 103
Analysis of whole-genome microarray replicates using mixed models
Wernisch, L., Kendall, S. L., Soneji, S., Wietzorrek, A., Parish, T., Hinds, J., Butcher, P. D., & Stoker, N. G. (2002) · Bioinformatics · doi:10.1093/bioinformatics/19.1.53 · Cited by 101
Use of in vivo complementation in Mycobacterium tuberculosis to identify a genomic fragment associated with virulence
Pascopella, L., Collins, F. M., Martin, J., Lee, M., Hatfull, G. F., Stover, C. K., Bloom, B. R., & Jacobs, W. R. (1994) · Infection and Immunity · doi:10.1128/iai.62.4.1313-1319.1994 · Cited by 100
Strains of Mycobacterium tuberculosis differ in susceptibility to reactive nitrogen intermediates in vitro
O’Brien, L. M., Carmichael, J., Lowrie, D. B., & Andrew, P. W. (1994) · Infection and Immunity · doi:10.1128/iai.62.11.5187-5190.1994 · Cited by 98
Analysis of the host-parasite equilibrium in chronic murine tuberculosis by total and viable bacillary counts.
Rees, R. J. W., & Hart, P. D. (1961) · PubMed · Cited by 98
sigA is an essential gene in Mycobacterium smegmatis
Gómez, M. J., Doukhan, L., Nair, G., & Smith, I. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00960.x · Cited by 97
Self-citation
The urease locus of Mycobacterium tuberculosis and its utilization for the demonstration of allelic exchange in Mycobacterium bovis bacillus Calmette-Guérin.
Reyrat, J., Berthet, F.-X., & Gicquel, B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8768 · Cited by 97
Introducing mutations into a chromosomal rRNA gene using a genetically modified eubacterial host with a single rRNA operon
Sander, P., Prammananan, T., & ̈ttger, E. C. B. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.01532.x · Cited by 97
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Tullius, M. V., Harth, G., & Horwitz, M. A. (2001) · Infection and Immunity · doi:10.1128/iai.69.10.6348-6363.2001 · Cited by 97
A Whole Blood Bactericidal Assay for Tuberculosis
Wallis, R. S., Palaci, M., Vinhas, S. A., Hise, A. G., Ribeiro, F. C., Landen, K., Cheon, S.-H., Song, H., Phillips, M., Dietze, R., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/319679 · Cited by 97
THE ORIGIN AND ERRATIC GLOBAL SPREAD OF TUBERCULOSIS
Stead, W. W. (1997) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70356-7 · Cited by 96
Role of Mycobacterium tuberculosis Copper-Zinc Superoxide Dismutase
Dussurget, O., Stewart, G. R., Neyrolles, O., Pescher, P., Young, D. B., & Marchal, G. (2001) · Infection and Immunity · doi:10.1128/iai.69.1.529-533.2001 · Cited by 96
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Ratledge, C., & Ewing, M. (1996) · Microbiology · doi:10.1099/13500872-142-8-2207 · Cited by 96
Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation
Dubey, V. S., Sirakova, T. D., & Kolattukudy, P. E. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03119.x · Cited by 95
The uraA locus and homologous recombination in Mycobacterium bovis BCG
Aldovini, A., Husson, R. N., & Young, R. A. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.22.7282-7289.1993 · Cited by 95
Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor
Manabe, Y. C., Saviola, B., Sun, L., Murphy, J. R., & Bishai, W. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12844 · Cited by 92
Conjugal transfer of chromosomal DNA in Mycobacterium smegmatis
Parsons, L. M., Jankowski, C. S., & Derbyshire, K. M. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00818.x · Cited by 92
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Barker, L. P., Brooks, D. M., & Small, P. L. C. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00996.x · Cited by 92
Mycobacterium tuberculosis 19-kDa Lipoprotein Promotes Neutrophil Activation
Neufert, C. F., Pai, R. K., Noss, E. H., Berger, M., Boom, W. H., & Harding, C. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1542 · Cited by 92
Virulence ofMycobacterium tuberculosisCDC1551 and H37Rv in Rabbits Evaluated by Lurie’s Pulmonary Tubercle Count Method
Bishai, W. R., Dannenberg, A. M., Parrish, N. M., Ruiz, R., Chen, P., Zook, B. C., Johnson, W., Boles, J. W., & Pitt, M. L. M. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4931-4934.1999 · Cited by 90
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BIRKNESS, K. A., Deslauriers, M., Bartlett, J. H., WHITE, E. H., King, C. H., & Quinn, F. D. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.653-658.1999 · Cited by 89
Binding of Catalase-Peroxidase-Activated Isoniazid to Wild-Type and Mutant Mycobacterium tuberculosis Enoyl-ACP Reductases
Quémard, A., Dessen, A., Sugantino, M., Jacobs, W. R., Sacchettini, J. C., & Blanchard, J. S. (1996) · Journal of the American Chemical Society · doi:10.1021/ja950998b · Cited by 89
Mycobacterium tuberculosis Chaperonin 10 Stimulates Bone Resorption: A Potential Contributory Factor in Pott's Disease
Meghji, S., White, P. A., Nair, S. P., Reddi, K., Heron, K., Henderson, B. E., Zaliani, A., Fossati, G., Mascagni, P., Hunt, J. F., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1241 · Cited by 89
Mycobacterium aviumGenes Expressed during Growth in Human Macrophages Detected by Selective Capture of Transcribed Sequences (SCOTS)
Hou, J. Y., Graham, J. E., & Clark‐Curtiss, J. E. (2002) · Infection and Immunity · doi:10.1128/iai.70.7.3714-3726.2002 · Cited by 89
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Ewann, F., Jackson, M., Pethe, K., Cooper, A. M., Mielcarek, N., Ensergueix, D., Gicquel, B., Locht, C., & Supply, P. (2002) · Infection and Immunity · doi:10.1128/iai.70.5.2256-2263.2002 · Cited by 88
The white plague
Dubos, R. J. (1987) · Cited by 86
Production of mutants in amino acid biosynthesis genes of Mycobacterium tuberculosis by homologous recombination
Parish, T., Gordhan, B. G., McAdam, R. A., Duncan, K., Mizrahi, V., & Stoker, N. G. (1999) · Microbiology · doi:10.1099/00221287-145-12-3497 · Cited by 83
H2O2 induces monocyte apoptosis and reduces viability of Mycobacterium avium-M. intracellulare within cultured human monocytes
Laochumroonvorapong, P., Paul, S., Elkon, K. B., & Kaplan, G. (1996) · Infection and Immunity · doi:10.1128/iai.64.2.452-459.1996 · Cited by 83
Inhibition of Mycobacterium tuberculosis Glutamine Synthetase as a Novel Antibiotic Strategy against Tuberculosis: Demonstration of Efficacy In Vivo
Harth, G., & Horwitz, M. A. (2002) · Infection and Immunity · doi:10.1128/iai.71.1.456-464.2003 · Cited by 83
Activity of mycobacterial promoters during intracellular and extracellular growth
Dellagostin, O. A., Esposito, G., Eales, L., Dale, J. W., & McFadden, J. (1995) · Microbiology · doi:10.1099/13500872-141-8-1785 · Cited by 82
Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance
Schüller, S., Neefjes, J., Ottenhoff, T. H. M., Thole, J. E. R., & Young, D. (2001) · Cellular Microbiology · doi:10.1046/j.1462-5822.2001.00155.x · Cited by 81
Construction and complementation of a recA deletion mutant of Mycobacterium smegmatis reveals that the intein in Mycobacterium tuberculosis recA does not affect RecA function
Papavinasasundaram, K. G., Colston, M. J., & Davis, E. O. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01083.x · Cited by 81
Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons
DeMaio, J. D., Zhang, Y., Ko, C., & Bishai, W. R. (1997) · Tubercle and Lung Disease · doi:10.1016/s0962-8479(97)90010-1 · Cited by 79
Site-Directed Mutagenesis of the 19-Kilodalton Lipoprotein Antigen Reveals No Essential Role for the Protein in the Growth and Virulence of Mycobacterium intracellulare
Mahenthiralingam, E., Marklund, B., Brooks, L. A., Smith, D. A., Bancroft, G. J., & Stokes, R. W. (1998) · Infection and Immunity · doi:10.1128/iai.66.8.3626-3634.1998 · Cited by 78
Molecular analysis of the dormancy response in Mycobacterium smegmatis: expression analysis of genes encoding the DevR–DevS two-component system, Rv3134c and chaperone α-crystallin homologues
Mayuri, Bagchi, G., Das, T. K., & Tyagi, J. S. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11230.x · Cited by 78
Transduction in Mycobacterium smegmatis
Raj, C. V. S., & Ramakrishnan, T. V. (1970) · Nature · doi:10.1038/228280b0 · Cited by 77
Magnesium and the Role of mgtC in Growth of Salmonella typhimurium
Moncrief, M. B. C., & Maguire, M. E. (1998) · Infection and Immunity · doi:10.1128/iai.66.8.3802-3809.1998 · Cited by 77
A proteomic approach to study the acid response inListeria monocytogenes
Phan‐Thanh, L., & Mahouin, F. (1999) · Electrophoresis · doi:10.1002/(sici)1522-2683(19990801)20:11 · Cited by 75
Evolution of drug-resistant tuberculosis: a tale of two species.
Iseman, M. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2428 · Cited by 73
The autoregulatory HspR repressor protein governs chaperone gene transcription in Helicobacter pylori
Spohn, G., & Scarlato, V. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01625.x · Cited by 73
Regulation of the dnaK operon of Streptomyces coelicolor A3(2) is governed by HspR, an autoregulatory repressor protein
Bucca, G., Hindle, Z., & Smith, C. P. S. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.19.5999-6004.1997 · Cited by 72
Use of fluorescence induction and sucrose counterselection to identify Mycobacterium tuberculosis genes expressed within host cells
Triccas, J. A., Gicquel, B., Berthet, F., & Pelicic, V. (1999) · Microbiology · doi:10.1099/00221287-145-10-2923 · Cited by 72
Mycobacteriumbovis BCG genes involved in the biosynthesis of cyclopropyl keto‐ and hydroxy‐mycolic acids
Dubnau, E., Lanéelle, M., Soares, S., Bénichou, A., Vaz, T., Promé, D., Promé, J., Daffé, M., & Quémard, A. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2301589.x · Cited by 72
New Vaccines for the Prevention of Tuberculosis
von Reyn, C. F., & Vuola, J. M. (2002) · Clinical Infectious Diseases · doi:10.1086/341901 · Cited by 70
Development and use of a conditional antisense mutagenesis system in mycobacteria
Parish, T., & Stoker, N. G. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1997.tb12637.x · Cited by 69
Recombination in mycobacteria
McFadden, J. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.6271345.x · Cited by 69
Mycobacteria and Human Disease
Grange, J. M. (1996) · Medical Entomology and Zoology · Cited by 66
Foreword from the Co-Editor-in-Chief
Brennan, P. J. (2001) · Tuberculosis · doi:10.1054/tube.2001.0288 · Cited by 64
Characterization of RNA polymerse and two sigma‐factor genes from Mycobacterium smegmatis
Predich, M., Doukhan, L., Nair, G., & Smith, I. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02249.x · Cited by 61
Self-citation
The 19-kD antigen and protective immunity in a murine model of tuberculosis
Yeremeev, V., Lyadova, I. V., Nikonenko, B. V., Apt, A. S., Abou-Zeid, C., Inwald, J. K., & Young, D. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01212.x · Cited by 61
Identification and characterization of two divergently transcribed iron regulated genes in Mycobacterium tuberculosis
Rodríguez, G. M., Gold, B., Gomez, M., Dussurget, O., & Smith, I. (1999) · Tubercle and Lung Disease · doi:10.1054/tuld.1999.0219 · Cited by 58
Self-citation
Mycobacterium tuberculosis19-Kilodalton Lipoprotein InhibitsMycobacterium smegmatis-Induced Cytokine Production by Human Macrophages In Vitro
Post, F. A., Manca, C., Neyrolles, O., Ryffel, B., Young, D. B., & Kaplan, G. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1433-1439.2001 · Cited by 58
Microarray analysis of bacterial pathogenicity
Schoolnik, G. K. (2002) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(02)46001-8 · Cited by 57
Thalidomide‐Induced Antigen‐Specific Immune Stimulation in Patients with Human Immunodeficiency Virus Type 1 and Tuberculosis
Bekker, L., Haslett, P. A. J., Maartens, G., Steyn, L. M., & Kaplan, G. (2000) · The Journal of Infectious Diseases · doi:10.1086/315328 · Cited by 57
Different Innate Ability of I/St and A/Sn Mice To Combat Virulent Mycobacterium tuberculosis : Phenotypes Expressed in Lung and Extrapulmonary Macrophages
Majorov, K. B., Lyadova, I. V., Kondratieva, T. K., Eruslanov, E. B., Rubakova, E. I., Orlova, M. O., Mischenko, V. V., & Apt, A. S. (2003) · Infection and Immunity · doi:10.1128/iai.71.2.697-707.2003 · Cited by 55
Historical Intensity of Natural Selection for Resistance to Tuberculosis
Lipsitch, M., & Sousa, A. O. (2002) · Genetics · doi:10.1093/genetics/161.4.1599 · Cited by 51
Genetic advances for studying Mycobacterium tuberculosis pathogenicity
Pelicic, V., Reyrat, J., & Gicquel, B. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00807.x · Cited by 51
Mycobacterium tuberculosis H37Rv comparative gene-expression analysis in synthetic medium and human macrophage
Mariani, F., Cappelli, G., Riccardi, G., & Colizzi, V. (2000) · Gene · doi:10.1016/s0378-1119(00)00249-3 · Cited by 47
Aromatic-dependent Salmonella as anti-bacterial vaccines and as presenters of heterologous antigens or of DNA encoding them
Stocker, B. A. D. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00297-2 · Cited by 44
Tuberculosis Control: the Relevance of Classic Principles in an Era of Acquired lmmunodeficiency Syndrome and Multidrug Resistance
Kaye, K., & Frieden, T. R. (1996) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a017916 · Cited by 44
Historical perspectives on the etiology of tuberculosis
Barnes, D. S. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00323-3 · Cited by 43
Characterization of the Mycobacterium tuberculosis erp gene encoding a potential cell surface protein with repetitive structures
Berthet, F.-X., Rauzier, J., Lim, E. M., Philipp, W. J., Gicquel, B., & Portnoi, D. (1995) · Microbiology · doi:10.1099/13500872-141-9-2123 · Cited by 42
Increased intracellular survival of Mycobacterium smegmatis containing the Mycobacterium leprae thioredoxin-thioredoxin reductase gene
Wieles, B., Ottenhoff, T. H. M., Steenwijk, T. M., Franken, K. L. M. C., de Vries, R. R., & Langermans, J. A. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.7.2537-2541.1997 · Cited by 42
Use of an arrayed promoter-probe library for the identification of macrophage-regulated genes in Mycobacterium tuberculosis
Hobson, R. J., McBride, A. J. A., Kempsell, K. E., & Dale, J. W. (2002) · Microbiology · doi:10.1099/00221287-148-5-1571 · Cited by 39
Investigation of mycobacterial recA function: protein introns in the RecA of pathogenic mycobacteria do not affect competency for homologous recombination
Frischkorn, K., Sander, P., Scholz, M., Teschner, K., Prammananan, T., & Böttger, E. C. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01003.x · Cited by 39
Tuberculosis and poverty.
Waaler, H. T. (2002) · PubMed · Cited by 39
Intracellular Gene Expression: Analysis of RNA from Mycobacteria in Macrophages Using RT-PCR
Butcher, P. D., Mangan, J. A., & Monahan, I. M. (2003) · Humana Press eBooks · doi:10.1385/0-89603-471-2:285 · Cited by 38
History of Tuberculosis
Daniel, T. M., Bates, J. H., & Downes, K. A. (2014) · Tuberculosis · doi:10.1128/9781555818357.ch2 · Cited by 38
Identification of genes differentially expressed inMycobacterium tuberculosisby differential display PCR
Rivera-Marrero, C. A., Burroughs, M., Masse, R. A., Vannberg, F. O., Leimbach, D. L., Roman, J., & Murtagh, J. J. (1998) · Microbial Pathogenesis · doi:10.1006/mpat.1998.0235 · Cited by 37
Identification of iron-regulated proteins ofMycobacterium tuberculosisand cloning of tandem genes encoding a low iron-induced protein and a metal transporting ATPase with similarities to two-component metal transport systems
Calder, K. M., & Horwitz, M. A. (1998) · Microbial Pathogenesis · doi:10.1006/mpat.1997.9999 · Cited by 36
Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth
Jensen-Cain, D. M., & Quinn, F. D. (2001) · Microbial Pathogenesis · doi:10.1006/mpat.2001.0431 · Cited by 35
Lack of production of the 19-kDa glycolipoprotein in certain strains of Mycobacterium tuberculosis.
Lathigra, R., Zhang, Y., Hill, M., García, M. J., Jackett, P., & Ivanyi, J. (1996) · Research in Microbiology · doi:10.1016/0923-2508(96)81384-2 · Cited by 34
Involvement of the fadD33 gene in the growth of Mycobacterium tuberculosis in the liver of BALB/c mice
Rindi, L., Fattorini, L., Bonanni, D., Iona, E., Freer, G., Tan, D., Dehò, G., Orefici, G., & Garzelli, C. (2002) · Microbiology · doi:10.1099/00221287-148-12-3873 · Cited by 34
Protective role of the Mycobacterium smegmatis IdeR against reactive oxygen species and isoniazid toxicity
Dussurget, O., Rodriguez, M., & Smith, I. (1998) · Tubercle and Lung Disease · doi:10.1054/tuld.1998.0011 · Cited by 32
Self-citation
Determining the Genomic Locations of Repetitive DNA Sequences with a Whole-Genome Microarray: IS 6110 in Mycobacterium tuberculosis
Kivi, M., Liu, X., Raychaudhuri, S., Altman, R. B., & Small, P. M. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.6.2192-2198.2002 · Cited by 31
Characterization of the heat shock response in Mycobacterium bovis BCG
Patel, B. K. R., Banerjee, D. K., & Butcher, P. D. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.24.7982-7987.1991 · Cited by 30
The Forgotten Plague
Ryan, F. (1993) · Cited by 27
Pathogenic and immunogenic differentiation of Mycobacterium tuberculosis grown in vitro and in vivo.
Segal, A. W., & Blöch, H. (1957) · PubMed · doi:10.1164/artpd.1957.75.3.495 · Cited by 26
Deletion of the 19kDa antigen does not alter the protective efficacy of BCG
Yeremeev, V., Stewart, G. R., Neyrolles, O., Skrabal, K., Авдиенко, В. Г., Apt, A. S., & Young, D. B. (2000) · Tubercle and Lung Disease · doi:10.1054/tuld.2000.0252 · Cited by 25
Real Time PCR Using Molecular Beacons: A New Tool to Identify Point Mutations and to Analyze Gene Expression in Mycobacterium tuberculosis
Manganelli, R., Tyagi, S., & Smith, I. (2003) · Humana Press eBooks · doi:10.1385/1-59259-147-7:295 · Cited by 24
Self-citation
A bacteriological survey of tuberculosis due to the human tubercle bacillus (Mycobacterium tuberculosis) in South-East England: 1984–91
Yates, M. D., & Grange, J. M. (1993) · Epidemiology and Infection · doi:10.1017/s0950268800051037 · Cited by 23
Molecular genetic characterisation of a mycobacterial homologue of a sporulation factor
Hutter, B., & Dick, T. (1999) · Research in Microbiology · doi:10.1016/s0923-2508(99)80055-2 · Cited by 20
Tuberculosis and the Human Immunodeficiency Virus Infection.
Nakata, K. (2000) · Japanese journal of leprosy · doi:10.5025/hansen.69.87 · Cited by 20
Interaction of Mycobacterium tuberculosis with MH-S, an immortalized murine alveolar macrophage cell line: a comparision with primary murine macrophages
Melo, M. D., & Stokes, R. W. (2000) · Tubercle and Lung Disease · doi:10.1054/tuld.1999.0228 · Cited by 19
Production of avirulent Mycobacterium bovis strains by illegitimate recombination with deoxyribonucleic acid fragments containing an interrupted ahpC gene
Wilson, T., Wards, B. J., White, S. J., Skou, B., de Lisle, G. W., & Collins, D. M. (1997) · Tubercle and Lung Disease · doi:10.1016/s0962-8479(97)90003-4 · Cited by 19
Metal ions modulate the plastic nature of Mycobacterium tuberculosis chaperonin-10
Taneja, B., & Mande, S. C. (2001) · Protein Engineering Design and Selection · doi:10.1093/protein/14.6.391 · Cited by 19
The immunogenicity of recombinant Mycobacterium smegmatis bearing BCG genes
Falcone, V., Bassey, E., Jacobs, W. R., & Collins, F. M. (1995) · Microbiology · doi:10.1099/13500872-141-5-1239 · Cited by 17
Tuberculosis research in a cold climate
Collins, F. M. (1998) · Tubercle and Lung Disease · doi:10.1016/s0962-8479(98)80002-6 · Cited by 15
Toward Mapping and Sequencing the Genome ofMycobacterium tuberculosis
Cole, S. T., & Smith, D. R. (2014) · ASM Press eBooks · doi:10.1128/9781555818357.ch16 · Cited by 14
Extra and intracellular expression of Mycobacterium tuberculosis genes
Smith, I., Dussurget, O., Rodríguez, G. M., Timm, J., Gomez, M., Dubnau, J., Gold, B., & Manganelli, R. (1998) · Tubercle and Lung Disease · doi:10.1054/tuld.1998.0010 · Cited by 14
Self-citation
Environment in its Relation to the Progress of Bacterial Invasion in Tuberculosis.
El, T. (1887) · PubMed · Cited by 11
Comparative Sequencing
Jacobs, W. R., Brennan, P. J., Curlin, G. T., Ginsberg, A. M., Adams, M. J., Fleischmann, R., Fraser, C. M., Venter, J. C., Shinnick, T. M., Bishai, W. R., et al. (1996) · Science · doi:10.1126/science.274.5284.17 · Cited by 9
ENVIRONMENT IN ITS RELATION TO THE PROGRESS OF BACTERIAL INVASION IN TUBERCULOSIS
Trudeau, E. L. (1887) · The American Journal of the Medical Sciences · doi:10.1097/00000441-188707000-00006 · Cited by 8
Preclinical candidates and targets for tuberculosis therapy.
Barry, C. E. (2001) · PubMed · Cited by 8
Comparative Sequencing
Jacobs, W., Brennan, P., Curlin, G., et al. (1996) · Science · doi:10.1126/science.274.5284.17a · Cited by 7
The Immune Response to Tuberculosis
Colston, M. J. (1997) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1997.tb06148.x · Cited by 6
Haussmann au crible
Chaudun, N. (2000) · Cited by 4

Flagged first, then by citations

Research works printed but not linked: 14

Butcher P. D. J. A. Mangan and I. M. Monahan. 1998. Intracellular gene expression p. 285-306. In T. Parish and N. G. Stoker (ed.) Mycobacterium tuberculosis protocols. Humana Press Totowa N.J.
Derbyshire, K. M., C. Takacs, and J. Huang. 2000. Using the EZ:TNTMTransposomeTM for transposon mutagenesis in Mycobacterium smegmatis.Epicentre Forum7:1-4.
Friedman L. N. (ed.). 2001. Tuberculosis: current concepts and treatment 2nd ed. CRC Press Inc. Boca Raton Fla.
Garay. S. 1996. Pulmonary tuberculosis. p. 373-412. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Gomez M. and I. Smith. 2000. Determinants of mycobacterial gene expression p. 111-129. In G. F. Hatfull and W. R. Jacobs Jr (ed.) Molcular genetics of mycobacteria. American Society for Microbiology Washington. D.C.
Haas F. and S. S. Haas. 1996. The origins of Mycobacterium tuberculosis and the notion of its contagiousness p. 3-19. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Hatfull G. F. and W. R. Jacobs Jr. (ed.). 2000. Molecular genetics of mycobacteria. American Society for Microbiology Washington D.C.
Jagirdar J. and D. ZagZag. 1996. Pathology and insights into pathogenesis of tuberculosis p. 467-491. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Kamholz S. L. 1996. Pleural tuberculosis p. 483-491. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Munger J. S. and J. H. A. Chapman. 1996. Tissue destruction by proteases p. 353-361. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Rom W. N. and S. Garay (ed.). 1996. Tuberculosis. Little Brown and Co. Boston Mass.
Talavera W. R. Miranda K. Lessnau and L. Klapholz. 2001. Extrapulmonary tuberculosis p. 139-190. In L. N. Friedman (ed.) Tuberculosis: current concepts and treatment 2nd ed. CRC Press Inc. Boca Raton Fla.
Tyagi A. K. S. K. D. Gupta and S. Jain. 2000. Gene expression: reporter technologies p. 131-147. In G. F. Hatfull and W. R. Jacobs Jr. (ed.) Molecular genetics of mycobacteria. American Society for Microbiology Washington D.C.
Zugar A. and F. D. Lowy. 1996. Tuberculosis of the brain meninges and the spinal cord p. 541-556. In W. N. Rom and S. Gary (ed.) Tuberculosis. Little Brown and Co. Boston Mass.

Sorted by citations

Intraocular Tuberculosis—An Update
Gupta, V., Gupta, A., & Rao, N. A. (2007) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2007.08.015 · Cited by 681
Virulence factors of the Mycobacterium tuberculosis complex
Forrellad, M. A., Klepp, L. I., Gioffré, A., y García, J. S., Morbidoni, H. R., Santangelo, M. D. L. P., Cataldi, A. A., & Bigi, F. (2013) · Virulence · doi:10.4161/viru.22329 · Cited by 676
The complete genome sequence of Mycobacterium avium subspecies paratuberculosis
Li, L., Bannantine, J. P., Zhang, Q., Amonsin, A., May, B. J., Alt, D. P., Banerji, N., Kanjilal, S., & Kapur, V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505662102 · Cited by 465
Next-generation sequencing: insights to advance clinical investigations of the microbiome
Wensel, C. R., Pluznick, J. L., Salzberg, S. L., & Sears, C. L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154944 · Cited by 437
THE MAGIC BULLETS AND TUBERCULOSIS DRUG TARGETS
Zhang, Y. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.100120 · Cited by 432

See all 1,154

Authors: Smith, I.
Affiliations: International Center for Public Health (US)
Corresponding author: Smith, Issar
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2003-07
Volume: 16
Issue: 3
Pages: 463-496
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.16.3.463-496.2003
PMC: PMC164219
OpenAlex: W2157638040
Cited by: 1,154
References: 322
Citations by year: 2026: 29 · 2025: 56 · 2024: 57 · 2023: 87 · 2022: 87 · 2021: 87 · 2020: 84 · 2019: 76 · 2018: 73 · 2017: 54 · 2016: 57 · 2015: 54 · 2014: 46 · 2013: 54 · 2012: 33
FWCI: 3.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01 HL 68513, R01HL064544, R01 HL 64544, R01HL068513)
National Institute of Allergy and Infectious Diseases (R01 AI 48856, R01AI048856)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, tuberculosis pathogenesis, bacterial virulence factors, host immune response, pulmonary tuberculosis, transmissibility, host genetics, host nutritional status, tuberculosis vaccine, tuberculosis drug targets, tuberculosis diagnosis
MeSH terms: Animals, Antitubercular Agents, Disease Models, Animal, Humans, Macrophages, Mycobacterium tuberculosis, Transcription, Genetic, Tuberculosis, Virulence, Genome, Bacterial, Proteomics

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Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

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