Virulence-Associated Enzymes of Cryptococcus neoformans
Open accessAbstract
Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or activity can significantly alter the infection process, and enzyme expression profiles can be a hallmark of disease. Hence, enzymes are worthy targets for better understanding pathogenesis and identifying new options for combatting fungal infections. Advances in genomics, proteomics, transcriptomics, and mass spectrometry have enabled the identification and characterization of new fungal enzymes. This review focuses on recent developments in the virulence-associated enzymes from Cryptococcus neoformans . The enzymatic suite of C. neoformans has evolved for environmental survival, but several of these enzymes play a dual role in colonizing the mammalian host. We also discuss new therapeutic and diagnostic strategies that could be based on the underlying enzymology.
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Extracellular enzymes such as lipases, proteases and DNases are secreted by Cryptococcus cells to damage host tissue, promote virulence and interfere with the immune response.
“During infection, extracellular enzymes (such as lipases, proteases and DNases) are secreted by Cryptococcus cells to damage host tissue, promote virulence and interfere with the immune response58.”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [58]
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References 207 · Cited by 141
- Authors
- Almeida, F., Wolf, J. M., & Casadevall, A.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2015-12
- Volume
- 14
- Issue
- 12
- Pages
- 1173-1185
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC4664877
- OpenAlex
- W2182008738
- Cited by
- 141
- References
- 207
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 16 · 2023: 11 · 2022: 9 · 2021: 17 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 12 · 2016: 16 · 2015: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ai052733-16, 5r37ai033142-24)
- National Institute of Allergy and Infectious Diseases (R37-AI033142, R01-AI052733)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
- Keywords
- Cryptococcus neoformans, fungal pathogenesis, host colonization, antifungal drug targets, environmental survival
- MeSH terms
- Animals, Cryptococcus neoformans, Humans, Melanins, Polysaccharides, Virulence, Drug Design, Drug Resistance, Fungal
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