Cited by 150Fungal and yeast genetics researchCancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Intracellular Acetyl Unit Transport in Fungal Carbon Metabolism

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Strijbis, Karin, Distel, Ben·2010·Eukaryotic Cell

Abstract

Acetyl coenzyme A (acetyl-CoA) is a central metabolite in carbon and energy metabolism. Because of its amphiphilic nature and bulkiness, acetyl-CoA cannot readily traverse biological membranes. In fungi, two systems for acetyl unit transport have been identified: a shuttle dependent on the carrier carnitine and a (peroxisomal) citrate synthase-dependent pathway. In the carnitine-dependent pathway, carnitine acetyltransferases exchange the CoA group of acetyl-CoA for carnitine, thereby forming acetyl-carnitine, which can be transported between subcellular compartments. Citrate synthase catalyzes the condensation of oxaloacetate and acetyl-CoA to form citrate that can be transported over the membrane. Since essential metabolic pathways such as fatty acid β-oxidation, the tricarboxylic acid (TCA) cycle, and the glyoxylate cycle are physically separated into different organelles, shuttling of acetyl units is essential for growth of fungal species on various carbon sources such as fatty acids, ethanol, acetate, or citrate. In this review we summarize the current knowledge on the different systems of acetyl transport that are operational during alternative carbon metabolism, with special focus on two fungal species: Saccharomyces cerevisiae and Candida albicans.

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Crossref · 10.1128/ec.00172-10

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Authors
Strijbis, K., & Distel, B.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
Venue
Eukaryotic Cell
Published
2010-12
Volume
9
Issue
12
Pages
1809-1815
ISSN
  • 1535-9778 (ISSN-L)
  • 1535-9786
OpenAlex
W2116259122
Cited by
148
References
55
Citations by year
2026: 9 · 2025: 16 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 11 · 2015: 15 · 2014: 9 · 2013: 5 · 2012: 7
FWCI
0.42
Type
journal article
Language
en
Open access
Locations
  • Eukaryotic Cell (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • UvA-DARE (University of Amsterdam) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
carnitine shuttle, carnitine acetyltransferase, acetyl-L-carnitine, citrate synthase, peroxisomes, citrate transport, fungal carbon metabolism, alternative carbon sources, fatty acid beta-oxidation, TCA cycle, glyoxylate cycle, subcellular compartmentalization, Saccharomyces cerevisiae, Candida albicans
MeSH terms
Acetyl Coenzyme A, Acetyltransferases, Candida albicans, Carbon, Fungal Proteins, Saccharomyces cerevisiae

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