Intracellular Acetyl Unit Transport in Fungal Carbon Metabolism
Open accessAbstract
Acetyl coenzyme A (acetyl-CoA) is a central metabolite in carbon and energy metabolism. Because of its amphiphilic nature and bulkiness, acetyl-CoA cannot readily traverse biological membranes. In fungi, two systems for acetyl unit transport have been identified: a shuttle dependent on the carrier carnitine and a (peroxisomal) citrate synthase-dependent pathway. In the carnitine-dependent pathway, carnitine acetyltransferases exchange the CoA group of acetyl-CoA for carnitine, thereby forming acetyl-carnitine, which can be transported between subcellular compartments. Citrate synthase catalyzes the condensation of oxaloacetate and acetyl-CoA to form citrate that can be transported over the membrane. Since essential metabolic pathways such as fatty acid β-oxidation, the tricarboxylic acid (TCA) cycle, and the glyoxylate cycle are physically separated into different organelles, shuttling of acetyl units is essential for growth of fungal species on various carbon sources such as fatty acids, ethanol, acetate, or citrate. In this review we summarize the current knowledge on the different systems of acetyl transport that are operational during alternative carbon metabolism, with special focus on two fungal species: Saccharomyces cerevisiae and Candida albicans.
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C. albicans employs the carnitine shuttle (YAT1, YAT2, CAT2) to assist in the transport of acetyl-CoA.
“C. albicans also employs the carnitine shuttle ( YAT1 , YAT2 , CAT2 ) to assist in the transport of acetyl-CoA (29)”
From <i>Candida auris</i> metabolism and growth preferences in physiologically relevant skin-like conditions (2026) · cites this paper as [29]
Both conventional and alternative carbon metabolism allow C. albicans to grow in various nutrient sources.
“Taken together, both conventional and alternative carbon metabolism allow C. albicans to grow in various nutrient sources.”
From <i>Candida auris</i> metabolism and growth preferences in physiologically relevant skin-like conditions (2026) · cites this paper as [29]
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- Authors
- Strijbis, K., & Distel, B.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2010-12
- Volume
- 9
- Issue
- 12
- Pages
- 1809-1815
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC3008284
- OpenAlex
- W2116259122
- Cited by
- 148
- References
- 55
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 11 · 2015: 15 · 2014: 9 · 2013: 5 · 2012: 7
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- carnitine shuttle, carnitine acetyltransferase, acetyl-L-carnitine, citrate synthase, peroxisomes, citrate transport, fungal carbon metabolism, alternative carbon sources, fatty acid beta-oxidation, TCA cycle, glyoxylate cycle, subcellular compartmentalization, Saccharomyces cerevisiae, Candida albicans
- MeSH terms
- Acetyl Coenzyme A, Acetyltransferases, Candida albicans, Carbon, Fungal Proteins, Saccharomyces cerevisiae
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