The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Vesicular Polysaccharide Export in Cryptococcus neoformans Is a Eukaryotic Solution to the Problem of Fungal Trans-Cell Wall Transport
Open accessAbstract
The mechanisms by which macromolecules are transported through the cell wall of fungi are not known. A central question in the biology of Cryptococcus neoformans , the causative agent of cryptococcosis, is the mechanism by which capsular polysaccharide synthesized inside the cell is exported to the extracellular environment for capsule assembly and release. We demonstrate that C. neoformans produces extracellular vesicles during in vitro growth and animal infection. Vesicular compartments, which are transferred to the extracellular space by cell wall passage, contain glucuronoxylomannan (GXM), a component of the cryptococcal capsule, and key lipids, such as glucosylceramide and sterols. A correlation between GXM-containing vesicles and capsule expression was observed. The results imply a novel mechanism for the release of the major virulence factor of C. neoformans whereby polysaccharide packaged in lipid vesicles crosses the cell wall and the capsule network to reach the extracellular environment.
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Citations
Cites
Cryptococcus neoformans Is a Facultative Intracellular Pathogen in Murine Pulmonary Infection
Feldmesser, M., Kress, Y., Novikoff, P., & Casadevall, A. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.4225-4237.2000 · Cited by 423
Self-citationTucker, S. C., & Casadevall, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052702799 · Cited by 306
Self-citationCasadevall, A., Cleare, W., Feldmesser, M., Glatman-Freedman, A., Goldman, D. L., Kozel, T. R., Lendvai, N., Mukherjee, J., Pirofski, L.-A., Rivera, J., et al. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.6.1437 · Cited by 298
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Cited by
Deatherage, B. L., & Cookson, B. T. (2012) · Infection and Immunity · doi:10.1128/iai.06014-11 · Cited by 770
Rodrigues, M. L., Nakayasu, E. S., Oliveira, D. L., Nimrichter, L., Nosanchuk, J. D., Almeida, I. C., & Casadevall, A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00370-07 · Cited by 558
Self-citationCandida albicans Cell Wall Proteins
Chaffin, W. L. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00032-07 · Cited by 515
Chapter 4 The Capsule of the Fungal Pathogen Cryptococcus neoformans
Zaragoza, O., Rodrigues, M. L., De Jesus, M., Frases, S., Dadachova, E., & Casadevall, A. (2009) · Advances in Applied Microbiology · doi:10.1016/s0065-2164(09)01204-0 · Cited by 457
Self-citationThe Spectrum of Fungi That Infects Humans
Kohler, J. R., Casadevall, A., & Perfect, J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019273 · Cited by 364
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Metadata
- Authors
- Rodrigues, M. L., Nimrichter, L., Oliveira, D. L., Frases, S., Miranda, K., Zaragoza, O., Alvarez, M., Nakouzi, A., Feldmesser, M., & Casadevall, A.
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2007-01
- Volume
- 6
- Issue
- 1
- Pages
- 48-59
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- OpenAlex
- W2170132701
- Cited by
- 491
- References
- 3
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Vesicular Polysaccharide Export in Cryptococcus neoformans Is a Eukaryotic Solution to the Problem of Fungal Trans-Cell Wall Transport. https://app.cochat.ai/papers/10.1128/ec.00318-06
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- Rodrigues, M. L., Nimrichter, L., Oliveira, D. L., Frases, S., Miranda, K., Zaragoza, O., Alvarez, M., Nakouzi, A., Feldmesser, M., & Casadevall, A. (2007). Vesicular Polysaccharide Export in Cryptococcus neoformans Is a Eukaryotic Solution to the Problem of Fungal Trans-Cell Wall Transport. Eukaryotic Cell. https://doi.org/10.1128/ec.00318-06
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
