The DOI matches its Crossref record; 318 of the 318 references it cites were found in a registry or an index.
Chapter 4 The Capsule of the Fungal Pathogen Cryptococcus neoformans
Open accessAbstract
The capsule of the fungal pathogen Cryptococcus neoformans has been studied extensively in recent decades, and a large body of information is now available to the scientific community. Well-known aspects of the capsule include its structure, antigenic properties and its function as a virulence factor. The capsule is composed primarily of two polysaccharides, glucuronoxylomannan (GXM) and galactoxylomannan (GalXM), in addition to a smaller proportion of mannoproteins (MP). Most of the studies on the composition of the capsule have focused on GXM, which comprises more than 90% of the capsule's polysaccharide mass. It is GalXM, however, that is of particular scientific interest because of its immunological properties. The molecular structure of these polysaccharides is very complex and has not yet been fully elucidated. Both GXM and GalXM are high molecular mass polymers with the mass of GXM equaling roughly 10 times that of GalXM. Recent findings suggest, however, that the actual Mw might be different to what it has traditionally been thought to be. In addition to their structural roles in the polysaccharide capsule, these molecules have been associated with many deleterious effects on the immune response. Capsular components are therefore considered key virulence determinants in Cryptococcus neoformans, which has motivated their use in vaccines and made them targets for monoclonal antibody treatments. In this review we will provide an update on the current knowledge of the C. neoformans capsule, covering aspects related to its structure, synthesis, and particularly, its role as a virulence factor.
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Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404
Biosynthesis and Assembly of Capsular Polysaccharides in Escherichia coli
Whitfield, C. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142545 · Cited by 990
Exosomes: endosomal-derived vesicles shipping extracellular messages
Février, B., & Raposo, G. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.003 · Cited by 881
The damage-response framework of microbial pathogenesis
Casadevall, A., & Pirofski, L.-A. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro732 · Cited by 658
Self-citationVincken, J.-P., Schols, H. A., Oomen, R. J. F. J., McCann, M. C., Ulvskov, P., Voragen, A. G. J., & Visser, R. G. F. (2003) · Plant Physiology · doi:10.1104/pp.103.022350 · Cited by 616
Rodrigues, M. L., Nakayasu, E. S., Oliveira, D. L., Nimrichter, L., Nosanchuk, J. D., Almeida, I. C., & Casadevall, A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00370-07 · Cited by 558
Self-citationCapsule Polysaccharide Mediates Bacterial Resistance to Antimicrobial Peptides
Campos, M. A., Vargas, M. A., Regueiro, V., Llompart, C. M., Albertí, S., & Bengoechea, J. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.12.7107-7114.2004 · Cited by 518
Steenbergen, J. N., Shuman, H. A., & Casadevall, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261418798 · Cited by 511
Self-citationRodrigues, M. L., Nimrichter, L., Oliveira, D. L., Frases, S., Miranda, K., Zaragoza, O., Alvarez, M., Nakouzi, A., Feldmesser, M., & Casadevall, A. (2007) · Eukaryotic Cell · doi:10.1128/ec.00318-06 · Cited by 491
Self-citationComplementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence.
Chang, Y. C., & Kwon-Chung, K. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4912 · Cited by 490
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May, R. C., Stone, N. R. H., Wiesner, D. L., Bicanic, T., & Nielsen, K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.6 · Cited by 541
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Innate Antifungal Immunity: The Key Role of Phagocytes
Brown, G. D. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101229 · Cited by 419
Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box
Kronstad, J. W., Attarian, R., Cadieux, B., Choi, J., D'Souza, C. A., Griffiths, E. J., Geddes, J. M. H., Hu, G., Jung, W. H., Kretschmer, M., et al. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2522 · Cited by 340
Metadata
- Authors
- Zaragoza, O., Rodrigues, M. L., De Jesus, M., Frases, S., Dadachova, E., & Casadevall, A.
- Venue
- Advances in Applied Microbiology
- Publisher
- Elsevier
- Published
- 2009
- Volume
- 68
- Pages
- 133-216
- ISSN
- 0065-2164 (ISSN-L)
- OpenAlex
- W1490724351
- Cited by
- 457
- References
- 318
- FWCI
- 94.28
- Type
- book chapter
- Language
- en
- Open access
- green
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